ENSG00000185187

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000526395 ENSG00000185187 HEK293_OSMI2_2hA HEK293_TMG_2hB SIGIRR protein_coding protein_coding 64.97473 138.3001 27.64834 8.230685 0.528235 -2.32212 47.24183 102.88997 17.32496 4.790246 0.7503391 -2.569486 0.7112083 0.7451667 0.6263333 -0.11883333 0.001506666 0.001506666 FALSE FALSE
ENST00000527987 ENSG00000185187 HEK293_OSMI2_2hA HEK293_TMG_2hB SIGIRR protein_coding retained_intron 64.97473 138.3001 27.64834 8.230685 0.528235 -2.32212 13.15970 27.41759 7.65662 2.313269 0.4851719 -1.838965 0.2115292 0.1976667 0.2774333 0.07976667 0.021473052 0.001506666 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185187 E001 6.1160950 0.0057303384 9.027738e-02 1.755608e-01 11 405716 405727 12 - 0.403 0.735 1.537
ENSG00000185187 E002 395.9289983 0.0018471438 8.642682e-01 9.165016e-01 11 405728 405871 144 - 2.429 2.426 -0.009
ENSG00000185187 E003 797.9628291 0.0001461543 2.124099e-02 5.409458e-02 11 405872 406059 188 - 2.694 2.733 0.130
ENSG00000185187 E004 14.7432003 0.0012174045 7.429924e-01 8.317616e-01 11 406060 406141 82 - 1.068 1.029 -0.141
ENSG00000185187 E005 42.9298337 0.0005225819 6.585950e-01 7.676771e-01 11 406142 406348 207 - 1.499 1.467 -0.112
ENSG00000185187 E006 515.1992052 0.0001394121 9.599119e-03 2.777603e-02 11 406349 406426 78 - 2.488 2.544 0.189
ENSG00000185187 E007 570.7366827 0.0001350497 4.385407e-01 5.804204e-01 11 406427 406538 112 - 2.567 2.583 0.052
ENSG00000185187 E008 40.1029760 0.0018863862 7.452023e-06 5.096803e-05 11 406539 406842 304 - 1.691 1.384 -1.053
ENSG00000185187 E009 123.8060050 0.0003450181 7.000104e-03 2.122381e-02 11 406843 406875 33 - 2.018 1.903 -0.384
ENSG00000185187 E010 174.9620793 0.0002721608 1.099952e-04 5.679550e-04 11 406876 406993 118 - 2.185 2.049 -0.455
ENSG00000185187 E011 31.4143042 0.0006688417 2.047264e-01 3.320516e-01 11 406994 407061 68 - 1.431 1.327 -0.361
ENSG00000185187 E012 258.3884261 0.0002039748 7.721567e-01 8.529216e-01 11 407062 407062 1 - 2.246 2.237 -0.030
ENSG00000185187 E013 330.9743923 0.0001656667 9.259480e-01 9.573706e-01 11 407063 407122 60 - 2.348 2.345 -0.008
ENSG00000185187 E014 166.9089456 0.0002397208 9.288930e-01 9.592691e-01 11 407123 407164 42 - 2.051 2.048 -0.012
ENSG00000185187 E015 11.5451039 0.0123531018 5.614918e-01 6.892907e-01 11 407165 407195 31 - 0.852 0.939 0.332
ENSG00000185187 E016 0.0000000       11 407233 407314 82 -      
ENSG00000185187 E017 0.0000000       11 407315 407424 110 -      
ENSG00000185187 E018 0.4428904 0.3887113882 1.000000e+00 1.000000e+00 11 407425 407451 27 - 0.001 0.111 6.989
ENSG00000185187 E019 0.0000000       11 407452 407526 75 -      
ENSG00000185187 E020 0.0000000       11 407527 407534 8 -      
ENSG00000185187 E021 0.0000000       11 407535 407568 34 -      
ENSG00000185187 E022 0.0000000       11 407817 407851 35 -      
ENSG00000185187 E023 0.0000000       11 407852 407888 37 -      
ENSG00000185187 E024 0.0000000       11 407889 407896 8 -      
ENSG00000185187 E025 0.0000000       11 407897 407957 61 -      
ENSG00000185187 E026 0.0000000       11 408073 408206 134 -      
ENSG00000185187 E027 0.0000000       11 408695 408762 68 -      
ENSG00000185187 E028 0.0000000       11 408763 408893 131 -      
ENSG00000185187 E029 0.0000000       11 408894 409101 208 -      
ENSG00000185187 E030 0.0000000       11 409217 409308 92 -      
ENSG00000185187 E031 0.0000000       11 409466 409859 394 -      
ENSG00000185187 E032 0.0000000       11 409860 409867 8 -      
ENSG00000185187 E033 0.0000000       11 409868 410027 160 -      
ENSG00000185187 E034 0.0000000       11 414823 415004 182 -      
ENSG00000185187 E035 0.0000000       11 417294 417324 31 -      
ENSG00000185187 E036 0.0000000       11 417325 417455 131 -