ENSG00000185164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330537 ENSG00000185164 HEK293_OSMI2_2hA HEK293_TMG_2hB NOMO2 protein_coding protein_coding 107.749 169.4605 68.93875 12.1105 0.05094749 -1.297438 32.23575 55.12171 18.75096 7.007932 3.025128 -1.555149 0.2897333 0.3257000 0.2719333 -0.05376667 7.140263e-01 1.563695e-48 FALSE TRUE
ENST00000620440 ENSG00000185164 HEK293_OSMI2_2hA HEK293_TMG_2hB NOMO2 protein_coding protein_coding 107.749 169.4605 68.93875 12.1105 0.05094749 -1.297438 39.18717 102.73215 0.00000 14.894510 0.000000 -13.326741 0.2686333 0.6020333 0.0000000 -0.60203333 1.563695e-48 1.563695e-48 FALSE TRUE
ENST00000622306 ENSG00000185164 HEK293_OSMI2_2hA HEK293_TMG_2hB NOMO2 protein_coding protein_coding 107.749 169.4605 68.93875 12.1105 0.05094749 -1.297438 33.51703 8.62193 47.49518 4.315380 1.775441 2.460330 0.4103292 0.0546000 0.6889667 0.63436667 8.707065e-02 1.563695e-48 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185164 E001 0.0000000       16 18417325 18417325 1 -      
ENSG00000185164 E002 0.0000000       16 18417326 18417329 4 -      
ENSG00000185164 E003 0.0000000       16 18417330 18417336 7 -      
ENSG00000185164 E004 0.0000000       16 18417337 18417509 173 -      
ENSG00000185164 E005 0.2965864 0.2481503895 3.188834e-01   16 18417510 18417840 331 - 0.000 0.197 10.711
ENSG00000185164 E006 0.1482932 0.0417948900 5.720411e-01   16 18417841 18417968 128 - 0.000 0.112 12.180
ENSG00000185164 E007 0.2214452 0.0423955482 5.692933e-01   16 18418392 18418431 40 - 0.000 0.112 12.180
ENSG00000185164 E008 0.2214452 0.0423955482 5.692933e-01   16 18418432 18418484 53 - 0.000 0.112 12.180
ENSG00000185164 E009 0.3666179 0.0318716159 8.969431e-01 9.381697e-01 16 18424274 18424393 120 - 0.134 0.112 -0.288
ENSG00000185164 E010 0.0000000       16 18424394 18424765 372 -      
ENSG00000185164 E011 0.1482932 0.0417948900 5.720411e-01   16 18426630 18426731 102 - 0.000 0.112 12.180
ENSG00000185164 E012 0.0000000       16 18429010 18429120 111 -      
ENSG00000185164 E013 0.1817044 0.0389204531 5.714397e-01   16 18430815 18430898 84 - 0.000 0.112 12.216
ENSG00000185164 E014 0.5149242 0.1675490225 7.224324e-01 8.165398e-01 16 18431807 18431948 142 - 0.134 0.202 0.713
ENSG00000185164 E015 0.0000000       16 18433348 18433475 128 -      
ENSG00000185164 E016 0.0000000       16 18434654 18434767 114 -      
ENSG00000185164 E017 0.0000000       16 18499925 18499926 2 -      
ENSG00000185164 E018 0.0000000       16 18499927 18499935 9 -      
ENSG00000185164 E019 0.0000000       16 18499936 18500108 173 -      
ENSG00000185164 E020 0.2965864 0.2481503895 3.188834e-01   16 18500109 18500439 331 - 0.000 0.197 12.324
ENSG00000185164 E021 0.1482932 0.0417948900 5.720411e-01   16 18500440 18500567 128 - 0.000 0.112 12.180
ENSG00000185164 E022 0.2214452 0.0423955482 5.692933e-01   16 18500991 18501083 93 - 0.000 0.112 12.180
ENSG00000185164 E023 0.2934659 0.0295263793 8.926012e-01   16 18506873 18506992 120 - 0.134 0.112 -0.293
ENSG00000185164 E024 0.1482932 0.0417948900 5.720411e-01   16 18509166 18509267 102 - 0.000 0.112 12.180
ENSG00000185164 E025 0.0000000       16 18511546 18511656 111 -      
ENSG00000185164 E026 0.3634088 0.2682341440 3.234046e-01   16 18513350 18513433 84 - 0.000 0.202 12.334
ENSG00000185164 E027 0.5149242 0.1675490225 7.224324e-01 8.165398e-01 16 18514342 18514483 142 - 0.134 0.202 0.713
ENSG00000185164 E028 0.0000000       16 18515883 18516010 128 -      
ENSG00000185164 E029 0.0000000       16 18517189 18517302 114 -      
ENSG00000185164 E030 12.5321229 0.0556151609 3.263501e-01 4.697921e-01 16 18519229 18519355 127 - 1.029 1.165 0.490
ENSG00000185164 E031 101.0428465 0.0003292532 3.622907e-05 2.109880e-04 16 18519501 18519660 160 - 1.912 2.054 0.478
ENSG00000185164 E032 153.2407923 0.0003479900 1.913345e-02 4.963066e-02 16 18520597 18520679 83 - 2.144 2.205 0.206
ENSG00000185164 E033 317.2533544 0.0003015105 4.890092e-06 3.489238e-05 16 18520765 18520819 55 - 2.441 2.528 0.291
ENSG00000185164 E034 356.2862195 0.0001979312 2.357224e-07 2.228277e-06 16 18520820 18520898 79 - 2.488 2.579 0.304
ENSG00000185164 E035 137.5052224 0.0002856566 6.400159e-05 3.510600e-04 16 18520899 18520983 85 - 2.057 2.174 0.392
ENSG00000185164 E036 80.1044857 0.0004611253 2.324708e-04 1.101932e-03 16 18523844 18523939 96 - 1.809 1.952 0.483
ENSG00000185164 E037 29.1075382 0.0007124246 6.126487e-02 1.287702e-01 16 18524489 18524552 64 - 1.400 1.515 0.397
ENSG00000185164 E038 18.4455339 0.0081690417 1.114132e-01 2.076262e-01 16 18527537 18527624 88 - 1.197 1.334 0.478
ENSG00000185164 E039 3.5835814 0.0045275976 2.912141e-01 4.320559e-01 16 18528013 18528071 59 - 0.754 0.595 -0.671
ENSG00000185164 E040 0.3697384 0.0254999719 2.523399e-01 3.886746e-01 16 18529409 18529500 92 - 0.000 0.201 13.386
ENSG00000185164 E041 45.2560316 0.0340245610 4.197184e-01 5.629775e-01 16 18529501 18529637 137 - 1.607 1.692 0.287
ENSG00000185164 E042 120.3669067 0.0138414493 3.871695e-01 5.313117e-01 16 18531037 18531168 132 - 2.044 2.099 0.185
ENSG00000185164 E043 298.6211341 0.0001998507 6.198944e-02 1.299673e-01 16 18531466 18531607 142 - 2.451 2.482 0.104
ENSG00000185164 E044 424.1837119 0.0002046846 7.150125e-01 8.110662e-01 16 18533005 18533179 175 - 2.628 2.614 -0.046
ENSG00000185164 E045 295.6307836 0.0010282084 8.605669e-01 9.140705e-01 16 18538526 18538629 104 - 2.470 2.458 -0.041
ENSG00000185164 E046 97.9755525 0.0003155692 9.513102e-01 9.735445e-01 16 18538630 18538676 47 - 1.992 1.982 -0.032
ENSG00000185164 E047 90.4689642 0.0010292673 1.235755e-01 2.250560e-01 16 18538859 18538964 106 - 1.920 1.973 0.180
ENSG00000185164 E048 57.0007096 0.0005220183 8.475030e-01 9.053067e-01 16 18542172 18542261 90 - 1.763 1.746 -0.055
ENSG00000185164 E049 118.2899064 0.0003949111 5.535599e-01 6.826691e-01 16 18542594 18542731 138 - 2.084 2.057 -0.090
ENSG00000185164 E050 0.4783925 0.0209461501 4.659434e-01 6.055368e-01 16 18542732 18542942 211 - 0.236 0.112 -1.291
ENSG00000185164 E051 145.6375941 0.0002412863 1.462665e-06 1.172666e-05 16 18543617 18543769 153 - 2.240 2.092 -0.494
ENSG00000185164 E052 41.3542060 0.0005054079 3.485407e-08 3.874544e-07 16 18547228 18547300 73 - 1.776 1.470 -1.040
ENSG00000185164 E053 34.0239418 0.0023758120 1.058974e-02 3.018467e-02 16 18549521 18549627 107 - 1.631 1.466 -0.565
ENSG00000185164 E054 17.2262171 0.0010791270 3.739377e-02 8.621569e-02 16 18551439 18551472 34 - 1.347 1.171 -0.619
ENSG00000185164 E055 65.7724420 0.0019215435 5.343710e-07 4.700296e-06 16 18551473 18551539 67 - 1.941 1.696 -0.828
ENSG00000185164 E056 64.5951818 0.0004434786 1.155234e-07 1.160422e-06 16 18554807 18554852 46 - 1.932 1.693 -0.809
ENSG00000185164 E057 135.5749178 0.0032387831 3.965827e-08 4.364553e-07 16 18557702 18557791 90 - 2.246 2.020 -0.758
ENSG00000185164 E058 0.1515154 0.0430077570 4.145462e-01   16 18558677 18558854 178 - 0.134 0.000 -13.364
ENSG00000185164 E059 170.0538055 0.0080925767 6.977569e-07 5.993831e-06 16 18561876 18562211 336 - 2.356 2.104 -0.841