ENSG00000185158

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000543378 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding protein_coding 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.66344018 0.53526545 0.94423135 0.13028043 0.17814110 0.8073803 0.20844583 0.21536667 0.28976667 0.07440000 7.266662e-01 3.712496e-11 FALSE TRUE
ENST00000578118 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding retained_intron 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.19418609 0.13456942 0.00000000 0.10068163 0.00000000 -3.8536905 0.05317500 0.03353333 0.00000000 -0.03353333 9.050329e-02 3.712496e-11 FALSE FALSE
ENST00000579094 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding retained_intron 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.40887604 0.21050178 0.35043142 0.07121529 0.07997153 0.7089345 0.12213333 0.07543333 0.10820000 0.03276667 7.556222e-01 3.712496e-11 FALSE TRUE
ENST00000579206 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding protein_coding 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.18459403 0.25087736 0.17390492 0.13652925 0.12612545 -0.5044117 0.05275833 0.07763333 0.05386667 -0.02376667 9.025149e-01 3.712496e-11 FALSE TRUE
ENST00000580871 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding processed_transcript 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.13923762 0.05653153 0.33158746 0.05653153 0.21403647 2.3601448 0.04069167 0.02360000 0.09723333 0.07363333 6.390445e-01 3.712496e-11 FALSE FALSE
ENST00000581370 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding processed_transcript 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.30043374 0.50247082 0.00000000 0.14317831 0.00000000 -5.6793979 0.09535417 0.16203333 0.00000000 -0.16203333 3.712496e-11 3.712496e-11   FALSE
ENST00000581786 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding processed_transcript 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.13393608 0.34843492 0.00000000 0.34843492 0.00000000 -5.1636393 0.03405417 0.07406667 0.00000000 -0.07406667 7.321462e-01 3.712496e-11 FALSE FALSE
ENST00000582815 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding retained_intron 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.07988164 0.24207950 0.05013944 0.07062351 0.05013944 -2.0674955 0.02507917 0.09173333 0.01380000 -0.07793333 1.816939e-01 3.712496e-11 FALSE FALSE
ENST00000583342 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding protein_coding 3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.34758246 0.15397238 0.54242677 0.09166718 0.27262359 1.7523305 0.10292917 0.04250000 0.17110000 0.12860000 7.143234e-01 3.712496e-11 FALSE TRUE
MSTRG.14089.4 ENSG00000185158 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37B protein_coding   3.330426 3.074821 3.272485 0.8188647 0.2281623 0.08960179 0.34194774 0.27383290 0.23453041 0.14164474 0.07699612 -0.2150279 0.09936667 0.08813333 0.06916667 -0.01896667 1.000000e+00 3.712496e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185158 E001 3.5688843 0.006575080 0.0115540512 0.032475720 17 32007872 32007973 102 + 0.803 0.399 -1.829
ENSG00000185158 E002 2.6100335 0.030858100 0.4039095837 0.547674649 17 32007974 32007987 14 + 0.612 0.461 -0.711
ENSG00000185158 E003 4.8778130 0.003506595 0.7885507839 0.864627327 17 32007988 32008035 48 + 0.783 0.742 -0.166
ENSG00000185158 E004 8.9093064 0.003121415 0.5251988093 0.658604376 17 32008036 32008132 97 + 1.024 0.950 -0.276
ENSG00000185158 E005 1.9875350 0.008133366 0.0007763626 0.003174128 17 32016925 32017220 296 + 0.108 0.678 3.741
ENSG00000185158 E006 2.5179932 0.568584883 0.4853608893 0.623238833 17 32017972 32018054 83 + 0.610 0.464 -0.688
ENSG00000185158 E007 3.9229541 0.195642419 0.5808399058 0.705528642 17 32020697 32020803 107 + 0.739 0.615 -0.525
ENSG00000185158 E008 0.2944980 0.248021074 0.3687850564   17 32021005 32021096 92 + 0.194 0.000 -12.149
ENSG00000185158 E009 0.1472490 0.042212490 0.6449240957   17 32021097 32021107 11 + 0.108 0.000 -11.149
ENSG00000185158 E010 0.1472490 0.042212490 0.6449240957   17 32021108 32021135 28 + 0.108 0.000 -11.149
ENSG00000185158 E011 0.1472490 0.042212490 0.6449240957   17 32021136 32021141 6 + 0.108 0.000 -11.149
ENSG00000185158 E012 0.2987644 0.029078516 0.2980971861   17 32021142 32021392 251 + 0.194 0.000 -12.150
ENSG00000185158 E013 29.7566596 0.014492735 0.1223890220 0.223356900 17 32021393 32022289 897 + 1.541 1.409 -0.452
ENSG00000185158 E014 21.7225545 0.009099893 0.0640714307 0.133475630 17 32022290 32022825 536 + 1.416 1.256 -0.556
ENSG00000185158 E015 5.9600509 0.003165434 0.3650173720 0.509354140 17 32024711 32024734 24 + 0.890 0.770 -0.466
ENSG00000185158 E016 5.0960254 0.003249559 0.3527156545 0.496950236 17 32024735 32024735 1 + 0.840 0.711 -0.515
ENSG00000185158 E017 8.5206900 0.002169148 0.6772630913 0.782021405 17 32024736 32024782 47 + 1.000 0.949 -0.189
ENSG00000185158 E018 6.9739770 0.002706566 0.7132632758 0.809809289 17 32027769 32027789 21 + 0.874 0.911 0.144
ENSG00000185158 E019 8.3778091 0.002030219 0.3851095922 0.529278437 17 32027790 32027840 51 + 1.012 0.911 -0.378
ENSG00000185158 E020 0.0000000       17 32028834 32028945 112 +      
ENSG00000185158 E021 9.7086120 0.001969246 0.5174147974 0.651811558 17 32030656 32030727 72 + 1.058 0.985 -0.267
ENSG00000185158 E022 6.4978008 0.016401719 0.6426181516 0.755378464 17 32031378 32031395 18 + 0.840 0.892 0.202
ENSG00000185158 E023 9.8048551 0.012529272 0.7020611917 0.800956661 17 32031396 32031458 63 + 1.013 1.048 0.129
ENSG00000185158 E024 0.0000000       17 32033977 32034065 89 +      
ENSG00000185158 E025 12.5079386 0.012052145 0.7114084890 0.808379875 17 32034910 32034981 72 + 1.118 1.150 0.115
ENSG00000185158 E026 12.8532616 0.001792977 0.1752714348 0.295023923 17 32035565 32035639 75 + 1.089 1.205 0.417
ENSG00000185158 E027 1.2866557 0.011368361 0.6700092432 0.776612245 17 32035640 32036023 384 + 0.328 0.399 0.418
ENSG00000185158 E028 2.9087344 0.007205297 0.5231453463 0.656895530 17 32036024 32036276 253 + 0.548 0.642 0.418
ENSG00000185158 E029 1.2168277 0.010619211 0.0675823492 0.139337157 17 32045487 32045536 50 + 0.473 0.139 -2.389
ENSG00000185158 E030 2.2270700 0.010232181 0.2885370110 0.429142626 17 32045537 32045699 163 + 0.582 0.399 -0.904
ENSG00000185158 E031 14.6214277 0.001410211 0.0213200671 0.054262639 17 32045700 32045818 119 + 1.098 1.288 0.674
ENSG00000185158 E032 4.4911216 0.007212192 0.9730750183 0.987196662 17 32047167 32047760 594 + 0.741 0.741 0.003
ENSG00000185158 E033 18.8021946 0.016641894 0.0556253454 0.119052440 17 32047761 32047901 141 + 1.210 1.388 0.623
ENSG00000185158 E034 0.0000000       17 32047902 32048029 128 +      
ENSG00000185158 E035 0.1472490 0.042212490 0.6449240957   17 32048978 32049101 124 + 0.108 0.000 -11.149
ENSG00000185158 E036 22.4540219 0.001011270 0.1634664166 0.279668228 17 32049102 32049394 293 + 1.328 1.418 0.314
ENSG00000185158 E037 6.4857565 0.017355364 0.1209299628 0.221278214 17 32050003 32050107 105 + 0.783 0.981 0.760
ENSG00000185158 E038 1.7349730 0.071430039 0.7053392095 0.803726766 17 32050108 32050582 475 + 0.473 0.398 -0.392
ENSG00000185158 E039 4.5024722 0.076207249 0.4072201360 0.550808624 17 32053266 32053504 239 + 0.668 0.835 0.677