ENSG00000185133

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331075 ENSG00000185133 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5J protein_coding protein_coding 7.137841 13.08168 4.327632 0.4603542 0.1219082 -1.59367 2.2940785 4.7686376 1.5288441 0.10343890 0.19227012 -1.63475229 0.33030000 0.36576667 0.35166667 -0.01410000 9.400320e-01 1.770757e-07 FALSE TRUE
ENST00000404390 ENSG00000185133 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5J protein_coding protein_coding 7.137841 13.08168 4.327632 0.4603542 0.1219082 -1.59367 0.5793683 0.9830757 0.0000000 0.55707146 0.00000000 -6.63383178 0.05505417 0.07800000 0.00000000 -0.07800000 2.905348e-01 1.770757e-07 FALSE TRUE
ENST00000404453 ENSG00000185133 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5J protein_coding protein_coding 7.137841 13.08168 4.327632 0.4603542 0.1219082 -1.59367 0.8234074 3.6677015 0.0000000 1.14275470 0.00000000 -8.52266059 0.06951250 0.27600000 0.00000000 -0.27600000 1.770757e-07 1.770757e-07 FALSE TRUE
ENST00000412277 ENSG00000185133 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5J protein_coding protein_coding 7.137841 13.08168 4.327632 0.4603542 0.1219082 -1.59367 0.4927128 0.7424710 0.2917237 0.16868624 0.18987669 -1.31840808 0.07599167 0.05603333 0.06913333 0.01310000 9.641601e-01 1.770757e-07 FALSE TRUE
ENST00000461241 ENSG00000185133 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5J protein_coding retained_intron 7.137841 13.08168 4.327632 0.4603542 0.1219082 -1.59367 0.4552644 0.3122400 0.3301909 0.07334467 0.02762438 0.07820902 0.08150417 0.02356667 0.07653333 0.05296667 3.925700e-03 1.770757e-07 FALSE TRUE
MSTRG.21953.1 ENSG00000185133 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5J protein_coding   7.137841 13.08168 4.327632 0.4603542 0.1219082 -1.59367 0.9467380 0.4324678 1.4322731 0.36092353 0.05579433 1.70470007 0.14883333 0.03126667 0.33080000 0.29953333 1.063787e-02 1.770757e-07 FALSE TRUE
MSTRG.21953.9 ENSG00000185133 HEK293_OSMI2_2hA HEK293_TMG_2hB INPP5J protein_coding   7.137841 13.08168 4.327632 0.4603542 0.1219082 -1.59367 1.0342206 1.9543910 0.1905074 0.42587292 0.19050738 -3.29235485 0.14044583 0.15183333 0.04513333 -0.10670000 2.010837e-01 1.770757e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185133 E001 0.0000000       22 31112167 31112209 43 +      
ENSG00000185133 E002 0.0000000       22 31122731 31122790 60 +      
ENSG00000185133 E003 1.4769815 0.0100126692 1.092193e-02 3.097496e-02 22 31122923 31122965 43 + 0.633 0.198 -2.509
ENSG00000185133 E004 2.6132652 0.0714342492 2.955574e-01 4.366804e-01 22 31122966 31122974 9 + 0.633 0.440 -0.906
ENSG00000185133 E005 7.1481996 0.0035884774 6.069465e-01 7.270073e-01 22 31122975 31122983 9 + 0.880 0.819 -0.236
ENSG00000185133 E006 12.8414198 0.0028960917 1.304536e-01 2.347882e-01 22 31122984 31122993 10 + 1.168 1.020 -0.536
ENSG00000185133 E007 35.3131202 0.0028626713 1.070583e-02 3.046608e-02 22 31122994 31123119 126 + 1.602 1.439 -0.559
ENSG00000185133 E008 0.7792333 0.0169247267 1.202479e-02 3.359079e-02 22 31123896 31124005 110 + 0.505 0.077 -3.510
ENSG00000185133 E009 6.6947012 0.0062117771 1.718005e-01 2.905550e-01 22 31124142 31124263 122 + 0.939 0.766 -0.671
ENSG00000185133 E010 38.5443366 0.0193910369 9.722278e-02 1.862368e-01 22 31124845 31124906 62 + 1.620 1.482 -0.472
ENSG00000185133 E011 157.0682357 0.0002694687 5.977494e-02 1.262324e-01 22 31124907 31125832 926 + 2.158 2.108 -0.166
ENSG00000185133 E012 58.8361044 0.0012513273 9.051224e-02 1.759362e-01 22 31125833 31126010 178 + 1.764 1.685 -0.270
ENSG00000185133 E013 1.2439081 0.1944312737 9.035655e-02 1.756841e-01 22 31126294 31126375 82 + 0.573 0.197 -2.252
ENSG00000185133 E014 58.1632929 0.0017854014 2.461135e-01 3.813900e-01 22 31126376 31126489 114 + 1.739 1.685 -0.184
ENSG00000185133 E015 53.6911452 0.0004555805 1.047867e-02 2.992797e-02 22 31126613 31126721 109 + 1.752 1.626 -0.426
ENSG00000185133 E016 6.2481124 0.0176267231 3.263786e-02 7.707351e-02 22 31126722 31126920 199 + 0.991 0.704 -1.115
ENSG00000185133 E017 32.6685176 0.0006688188 3.799526e-01 5.242294e-01 22 31126921 31127037 117 + 1.391 1.462 0.244
ENSG00000185133 E018 4.4921774 0.0037536493 1.332164e-02 3.666900e-02 22 31127038 31127356 319 + 0.911 0.568 -1.403
ENSG00000185133 E019 66.2042532 0.0025142077 8.347116e-02 1.649863e-01 22 31127357 31127532 176 + 1.811 1.729 -0.279
ENSG00000185133 E020 0.4460135 0.0263312049 8.643832e-03 2.539582e-02 22 31127760 31127788 29 + 0.423 0.000 -13.184
ENSG00000185133 E021 0.4460135 0.0263312049 8.643832e-03 2.539582e-02 22 31127789 31127801 13 + 0.423 0.000 -13.184
ENSG00000185133 E022 0.6277178 0.0195778166 4.155782e-02 9.392415e-02 22 31127802 31127950 149 + 0.423 0.077 -3.095
ENSG00000185133 E023 62.3400572 0.0004499602 3.424766e-01 4.864749e-01 22 31127951 31128062 112 + 1.756 1.717 -0.133
ENSG00000185133 E024 1.1050636 0.0194576254 6.831624e-01 7.864508e-01 22 31128063 31128213 151 + 0.322 0.249 -0.506
ENSG00000185133 E025 74.2695122 0.0023474742 3.944600e-01 5.382906e-01 22 31128214 31128323 110 + 1.822 1.787 -0.116
ENSG00000185133 E026 108.8645067 0.0019586230 1.366482e-01 2.434074e-01 22 31128471 31128654 184 + 1.901 1.974 0.246
ENSG00000185133 E027 91.7302793 0.0003672333 3.181839e-02 7.550211e-02 22 31133098 31133235 138 + 1.807 1.909 0.342
ENSG00000185133 E028 55.4086085 0.0004385904 4.141231e-01 5.575255e-01 22 31133406 31133483 78 + 1.631 1.684 0.179
ENSG00000185133 E029 92.9346056 0.0019735115 5.284585e-03 1.670668e-02 22 31133610 31133714 105 + 1.784 1.927 0.480
ENSG00000185133 E030 2.3123369 0.0341593378 7.018946e-01 8.008518e-01 22 31133715 31133912 198 + 0.505 0.439 -0.330
ENSG00000185133 E031 223.6959605 0.0038383526 3.650355e-07 3.318850e-06 22 31133913 31134697 785 + 2.108 2.312 0.681