ENSG00000185055

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460135 ENSG00000185055 HEK293_OSMI2_2hA HEK293_TMG_2hB EFCAB10 protein_coding protein_coding 0.7696377 0.5863955 1.180662 0.1176445 0.083616 0.9974222 0.01153373 0.00000000 0.07686205 0.00000000 0.076862048 3.1187260 0.02200000 0.0000000 0.05753333 0.05753333 0.907225968 0.005336922   FALSE
ENST00000480514 ENSG00000185055 HEK293_OSMI2_2hA HEK293_TMG_2hB EFCAB10 protein_coding protein_coding 0.7696377 0.5863955 1.180662 0.1176445 0.083616 0.9974222 0.13519360 0.14626329 0.16798043 0.07319595 0.167980431 0.1877398 0.23064583 0.2174000 0.14530000 -0.07210000 0.598048423 0.005336922 FALSE TRUE
ENST00000485614 ENSG00000185055 HEK293_OSMI2_2hA HEK293_TMG_2hB EFCAB10 protein_coding protein_coding 0.7696377 0.5863955 1.180662 0.1176445 0.083616 0.9974222 0.27527462 0.31131701 0.42030519 0.08804697 0.144375851 0.4213629 0.32223333 0.5563667 0.35580000 -0.20056667 0.619834277 0.005336922 FALSE TRUE
ENST00000486180 ENSG00000185055 HEK293_OSMI2_2hA HEK293_TMG_2hB EFCAB10 protein_coding protein_coding 0.7696377 0.5863955 1.180662 0.1176445 0.083616 0.9974222 0.23397230 0.06076208 0.51551401 0.03181438 0.003891345 2.8926809 0.31517917 0.1109667 0.44140000 0.33043333 0.005336922 0.005336922 FALSE TRUE
ENST00000490493 ENSG00000185055 HEK293_OSMI2_2hA HEK293_TMG_2hB EFCAB10 protein_coding protein_coding 0.7696377 0.5863955 1.180662 0.1176445 0.083616 0.9974222 0.04479974 0.06805314 0.00000000 0.06805314 0.000000000 -2.9644566 0.05537083 0.1152333 0.00000000 -0.11523333 0.629984553 0.005336922   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185055 E001 0.3030308 0.238867822 0.51174645   7 105565120 105565123 4 - 0.173 0.000 -9.439
ENSG00000185055 E002 0.7447899 0.017912701 0.84442189 0.90317142 7 105565124 105565232 109 - 0.238 0.272 0.254
ENSG00000185055 E003 4.5623871 0.015956920 0.09143645 0.17737598 7 105565233 105565447 215 - 0.644 0.875 0.932
ENSG00000185055 E004 3.8467420 0.004794813 0.05858187 0.12419744 7 105565448 105565615 168 - 0.565 0.823 1.081
ENSG00000185055 E005 4.7910240 0.023657686 0.01389702 0.03799334 7 105566323 105567101 779 - 0.878 0.501 -1.595
ENSG00000185055 E006 2.3731731 0.007019589 0.85181967 0.90812478 7 105567102 105567194 93 - 0.535 0.502 -0.158
ENSG00000185055 E007 4.6045227 0.008740287 0.61393799 0.73251948 7 105567195 105567466 272 - 0.768 0.692 -0.311
ENSG00000185055 E008 3.6537267 0.013184036 0.70865759 0.80626655 7 105567467 105567490 24 - 0.644 0.692 0.204
ENSG00000185055 E009 0.0000000       7 105568917 105569202 286 -      
ENSG00000185055 E010 7.5266991 0.002706566 0.32078110 0.46394534 7 105569203 105569290 88 - 0.967 0.851 -0.438
ENSG00000185055 E011 0.0000000       7 105569291 105569406 116 -      
ENSG00000185055 E012 10.3923556 0.002898639 0.47568443 0.61438234 7 105569407 105569571 165 - 1.030 1.091 0.219
ENSG00000185055 E013 6.1751810 0.002840450 0.76018415 0.84435998 7 105581358 105581690 333 - 0.865 0.824 -0.158
ENSG00000185055 E014 0.0000000       7 105591305 105591391 87 -      
ENSG00000185055 E015 0.0000000       7 105591392 105591520 129 -      
ENSG00000185055 E016 0.0000000       7 105600764 105600875 112 -