ENSG00000185024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327359 ENSG00000185024 HEK293_OSMI2_2hA HEK293_TMG_2hB BRF1 protein_coding protein_coding 29.90862 45.81967 23.47397 3.337866 1.133549 -0.9646055 2.6877848 3.040260 3.227984 1.2418540 0.53104086 0.08616389 0.11097083 0.06356667 0.13990000 0.076333333 3.449790e-01 2.915172e-06 FALSE TRUE
ENST00000392557 ENSG00000185024 HEK293_OSMI2_2hA HEK293_TMG_2hB BRF1 protein_coding protein_coding 29.90862 45.81967 23.47397 3.337866 1.133549 -0.9646055 3.2890062 5.661858 1.913902 0.3868730 0.05168479 -1.55978606 0.10977500 0.12366667 0.08210000 -0.041566667 9.487588e-03 2.915172e-06 FALSE TRUE
ENST00000446501 ENSG00000185024 HEK293_OSMI2_2hA HEK293_TMG_2hB BRF1 protein_coding protein_coding 29.90862 45.81967 23.47397 3.337866 1.133549 -0.9646055 10.3518030 21.522694 5.583933 1.5180751 0.44847431 -1.94459400 0.31358333 0.47166667 0.23826667 -0.233400000 2.915172e-06 2.915172e-06 FALSE TRUE
ENST00000547530 ENSG00000185024 HEK293_OSMI2_2hA HEK293_TMG_2hB BRF1 protein_coding protein_coding 29.90862 45.81967 23.47397 3.337866 1.133549 -0.9646055 2.9295900 3.601050 2.571099 0.1933056 0.34878942 -0.48443287 0.09380417 0.07986667 0.10870000 0.028833333 3.349980e-01 2.915172e-06 FALSE TRUE
MSTRG.10294.10 ENSG00000185024 HEK293_OSMI2_2hA HEK293_TMG_2hB BRF1 protein_coding   29.90862 45.81967 23.47397 3.337866 1.133549 -0.9646055 0.2900971 0.000000 1.610116 0.0000000 0.92196854 7.33995298 0.01303750 0.00000000 0.06516667 0.065166667 1.238419e-01 2.915172e-06 FALSE TRUE
MSTRG.10294.4 ENSG00000185024 HEK293_OSMI2_2hA HEK293_TMG_2hB BRF1 protein_coding   29.90862 45.81967 23.47397 3.337866 1.133549 -0.9646055 2.7727769 3.726006 1.954328 0.4764124 1.02206181 -0.92746106 0.09557500 0.08073333 0.08776667 0.007033333 9.038302e-01 2.915172e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185024 E001 0.9263925 0.1837195266 5.692025e-01 6.957936e-01 14 105209286 105209288 3 - 0.174 0.311 1.091
ENSG00000185024 E002 133.4884223 0.0050882482 2.708726e-04 1.261238e-03 14 105209289 105209428 140 - 1.918 2.122 0.684
ENSG00000185024 E003 155.0053519 0.0054629162 7.309199e-05 3.950771e-04 14 105209429 105209495 67 - 1.971 2.189 0.730
ENSG00000185024 E004 320.6233929 0.0031699389 2.342234e-08 2.693839e-07 14 105209496 105209659 164 - 2.281 2.502 0.737
ENSG00000185024 E005 517.3417343 0.0051591159 5.011954e-10 7.842568e-09 14 105209660 105210077 418 - 2.454 2.717 0.878
ENSG00000185024 E006 406.1726515 0.0024518359 1.694267e-09 2.405740e-08 14 105210078 105210277 200 - 2.393 2.603 0.697
ENSG00000185024 E007 288.6596390 0.0001833674 3.825057e-05 2.215432e-04 14 105210278 105210366 89 - 2.318 2.434 0.389
ENSG00000185024 E008 436.3780385 0.0006652903 3.936009e-01 5.374938e-01 14 105210367 105210588 222 - 2.556 2.594 0.123
ENSG00000185024 E009 413.2495122 0.0003212091 5.721108e-01 6.982694e-01 14 105211122 105211293 172 - 2.540 2.569 0.096
ENSG00000185024 E010 28.1845300 0.0106786948 1.300906e-01 2.342930e-01 14 105211294 105212112 819 - 1.490 1.380 -0.380
ENSG00000185024 E011 257.4442178 0.0002265543 7.813514e-02 1.564743e-01 14 105212113 105212164 52 - 2.311 2.373 0.204
ENSG00000185024 E012 2.8323445 0.0069881589 5.695339e-01 6.960794e-01 14 105212165 105213428 1264 - 0.471 0.581 0.518
ENSG00000185024 E013 2.0586118 0.1824126208 9.020754e-01 9.416040e-01 14 105217213 105217278 66 - 0.393 0.448 0.294
ENSG00000185024 E014 263.3435516 0.0001715760 7.446068e-01 8.328769e-01 14 105217544 105217632 89 - 2.348 2.373 0.081
ENSG00000185024 E015 355.2766616 0.0022126107 6.964509e-01 7.968042e-01 14 105217633 105217800 168 - 2.490 2.498 0.025
ENSG00000185024 E016 227.6427713 0.0026051717 1.494604e-01 2.609348e-01 14 105218998 105219053 56 - 2.325 2.294 -0.106
ENSG00000185024 E017 249.7165025 0.0004759705 1.312863e-02 3.620769e-02 14 105219151 105219232 82 - 2.375 2.327 -0.159
ENSG00000185024 E018 8.2708206 0.0047477663 8.375220e-01 8.984181e-01 14 105219233 105219298 66 - 0.922 0.911 -0.041
ENSG00000185024 E019 19.7411280 0.0009122347 2.436206e-03 8.570219e-03 14 105219299 105220068 770 - 1.415 1.190 -0.787
ENSG00000185024 E020 196.9558938 0.0002305274 2.445868e-02 6.076645e-02 14 105220069 105220127 59 - 2.271 2.225 -0.155
ENSG00000185024 E021 91.8049206 0.0003157158 8.387187e-02 1.656123e-01 14 105220128 105220130 3 - 1.948 1.894 -0.180
ENSG00000185024 E022 323.6277223 0.0009461754 2.161562e-02 5.487824e-02 14 105221648 105221884 237 - 2.483 2.443 -0.135
ENSG00000185024 E023 125.2645589 0.0002565978 9.496572e-03 2.752849e-02 14 105221885 105221914 30 - 2.097 2.024 -0.244
ENSG00000185024 E024 11.4792142 0.0178342042 2.564860e-02 6.321475e-02 14 105221915 105222545 631 - 1.209 0.966 -0.882
ENSG00000185024 E025 111.3806535 0.0003073645 1.808163e-02 4.730585e-02 14 105226069 105226102 34 - 2.042 1.972 -0.236
ENSG00000185024 E026 83.3812935 0.0060234194 1.380495e-02 3.778363e-02 14 105226103 105226113 11 - 1.953 1.836 -0.394
ENSG00000185024 E027 78.1518057 0.0038766286 5.104435e-03 1.621536e-02 14 105226114 105226122 9 - 1.931 1.805 -0.425
ENSG00000185024 E028 116.4170108 0.0061805261 1.646339e-02 4.375717e-02 14 105226123 105226161 39 - 2.088 1.985 -0.346
ENSG00000185024 E029 123.9336049 0.0026898266 4.525052e-03 1.461326e-02 14 105226251 105226290 40 - 2.113 2.013 -0.338
ENSG00000185024 E030 207.7730846 0.0026119194 1.193628e-02 3.337848e-02 14 105226634 105226760 127 - 2.315 2.244 -0.238
ENSG00000185024 E031 12.0679868 0.0014359852 5.978337e-04 2.525678e-03 14 105226761 105228270 1510 - 1.270 0.954 -1.141
ENSG00000185024 E032 113.8083200 0.0025712560 9.614502e-02 1.845840e-01 14 105228820 105228860 41 - 2.042 1.988 -0.182
ENSG00000185024 E033 118.5377548 0.0031254416 3.364127e-02 7.904201e-02 14 105228861 105228913 53 - 2.074 1.999 -0.251
ENSG00000185024 E034 70.5878425 0.0099427515 3.199483e-01 4.630323e-01 14 105241265 105241304 40 - 1.830 1.786 -0.151
ENSG00000185024 E035 106.1720937 0.0038807728 7.394829e-02 1.498303e-01 14 105241305 105241414 110 - 2.021 1.955 -0.223
ENSG00000185024 E036 4.1987805 0.0926259159 3.384005e-01 4.822761e-01 14 105241415 105242605 1191 - 0.471 0.704 1.049
ENSG00000185024 E037 49.0241949 0.0004697085 7.415900e-01 8.306992e-01 14 105247071 105247287 217 - 1.620 1.654 0.117
ENSG00000185024 E038 120.0073311 0.0002732321 9.460151e-02 1.822821e-01 14 105247288 105248074 787 - 2.059 2.017 -0.144
ENSG00000185024 E039 44.8948384 0.0113842322 1.363969e-03 5.189585e-03 14 105248075 105249148 1074 - 1.758 1.541 -0.740
ENSG00000185024 E040 12.4421700 0.0017542080 3.981782e-06 2.898285e-05 14 105249149 105249404 256 - 1.334 0.911 -1.527
ENSG00000185024 E041 60.7800235 0.0006984504 8.272715e-04 3.356983e-03 14 105252507 105252514 8 - 1.833 1.687 -0.496
ENSG00000185024 E042 89.7294202 0.0061104224 1.650330e-02 4.385078e-02 14 105252515 105252579 65 - 1.978 1.867 -0.374
ENSG00000185024 E043 27.6415722 0.0007201947 7.042451e-03 2.133413e-02 14 105256186 105256517 332 - 1.222 1.451 0.797
ENSG00000185024 E044 96.5935158 0.0020277346 4.419781e-01 5.836407e-01 14 105256518 105256549 32 - 1.943 1.926 -0.057
ENSG00000185024 E045 150.2744231 0.0002247510 2.684138e-03 9.326033e-03 14 105272721 105272894 174 - 2.179 2.101 -0.260
ENSG00000185024 E046 88.8135145 0.0002995471 3.195332e-04 1.459052e-03 14 105286296 105286376 81 - 1.987 1.859 -0.429
ENSG00000185024 E047 100.6334270 0.0002879329 2.319072e-23 2.130656e-21 14 105300446 105301278 833 - 2.173 1.831 -1.147
ENSG00000185024 E048 1.2147488 0.0116587739 4.719979e-01 6.110832e-01 14 105315322 105315341 20 - 0.393 0.271 -0.764
ENSG00000185024 E049 2.9130869 0.0052179111 3.271576e-01 4.706128e-01 14 105315342 105315589 248 - 0.646 0.500 -0.665