ENSG00000185010

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330287 ENSG00000185010 HEK293_OSMI2_2hA HEK293_TMG_2hB F8 protein_coding protein_coding 0.7594906 0.4613809 0.9007306 0.1522433 0.02569024 0.9501311 0.019580150 0.03056191 0.0000000 0.030561905 0.00000000 -2.0201254 0.04942917 0.06356667 0.0000000 -0.06356667 0.51820399 0.04666699 FALSE TRUE
ENST00000360256 ENSG00000185010 HEK293_OSMI2_2hA HEK293_TMG_2hB F8 protein_coding protein_coding 0.7594906 0.4613809 0.9007306 0.1522433 0.02569024 0.9501311 0.274512098 0.09246930 0.5098831 0.011422065 0.04165081 2.3429954 0.34323750 0.26253333 0.5658333 0.30330000 0.04666699 0.04666699 FALSE TRUE
ENST00000423959 ENSG00000185010 HEK293_OSMI2_2hA HEK293_TMG_2hB F8 protein_coding protein_coding 0.7594906 0.4613809 0.9007306 0.1522433 0.02569024 0.9501311 0.395679551 0.23877453 0.3908475 0.184272209 0.03797755 0.6882147 0.44409167 0.36013333 0.4341667 0.07403333 0.90977667 0.04666699 FALSE FALSE
ENST00000453950 ENSG00000185010 HEK293_OSMI2_2hA HEK293_TMG_2hB F8 protein_coding protein_coding 0.7594906 0.4613809 0.9007306 0.1522433 0.02569024 0.9501311 0.038054753 0.05747593 0.0000000 0.057475926 0.00000000 -2.7543729 0.07195000 0.11956667 0.0000000 -0.11956667 0.56785247 0.04666699 FALSE FALSE
ENST00000483822 ENSG00000185010 HEK293_OSMI2_2hA HEK293_TMG_2hB F8 protein_coding processed_transcript 0.7594906 0.4613809 0.9007306 0.1522433 0.02569024 0.9501311 0.003389602 0.02711682 0.0000000 0.027116816 0.00000000 -1.8920729 0.01797500 0.14380000 0.0000000 -0.14380000 0.66610696 0.04666699 FALSE TRUE
ENST00000644698 ENSG00000185010 HEK293_OSMI2_2hA HEK293_TMG_2hB F8 protein_coding protein_coding 0.7594906 0.4613809 0.9007306 0.1522433 0.02569024 0.9501311 0.024323826 0.01498241 0.0000000 0.007951616 0.00000000 -1.3209129 0.06294167 0.05036667 0.0000000 -0.05036667 0.28191207 0.04666699 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185010 E001 0.0000000       X 154835788 154835791 4 -      
ENSG00000185010 E002 2.0251149 0.246586360 5.929961e-02 1.254342e-01 X 154835792 154836046 255 - 0.283 0.734 2.268
ENSG00000185010 E003 16.5844540 0.001825197 1.530967e-01 2.658818e-01 X 154836047 154837752 1706 - 1.165 1.288 0.433
ENSG00000185010 E004 3.2277511 0.005194820 2.523931e-01 3.887408e-01 X 154860432 154860608 177 - 0.635 0.435 -0.942
ENSG00000185010 E005 2.0378781 0.061755364 4.737372e-01 6.126582e-01 X 154861718 154861866 149 - 0.481 0.334 -0.810
ENSG00000185010 E006 2.4066861 0.006451638 6.858087e-01 7.884384e-01 X 154863083 154863227 145 - 0.507 0.436 -0.356
ENSG00000185010 E007 0.0000000       X 154882037 154882472 436 -      
ENSG00000185010 E008 0.0000000       X 154883589 154884439 851 -      
ENSG00000185010 E009 0.0000000       X 154886134 154886317 184 -      
ENSG00000185010 E010 2.8183579 0.005565387 1.536805e-01 2.666707e-01 X 154896077 154896232 156 - 0.596 0.333 -1.356
ENSG00000185010 E011 1.7747164 0.008325400 1.498118e-01 2.614255e-01 X 154899866 154899951 86 - 0.481 0.197 -1.817
ENSG00000185010 E012 1.6994735 0.008626917 6.195928e-01 7.369577e-01 X 154901371 154901442 72 - 0.424 0.333 -0.527
ENSG00000185010 E013 1.8468362 0.161293901 6.380019e-01 7.517654e-01 X 154902051 154902167 117 - 0.453 0.333 -0.675
ENSG00000185010 E014 2.8892327 0.005343676 3.575206e-01 5.019166e-01 X 154903906 154904088 183 - 0.596 0.435 -0.773
ENSG00000185010 E015 3.5170523 0.004533236 5.070748e-02 1.104232e-01 X 154904296 154904524 229 - 0.687 0.333 -1.749
ENSG00000185010 E016 3.9244683 0.004557949 3.052640e-01 4.473203e-01 X 154904811 154905023 213 - 0.687 0.519 -0.748
ENSG00000185010 E017 1.5198585 0.009362038 2.481175e-01 3.837122e-01 X 154906420 154906573 154 - 0.424 0.197 -1.527
ENSG00000185010 E018 12.3018497 0.004288009 5.958977e-03 1.850005e-02 X 154928571 154930152 1582 - 1.149 0.829 -1.186
ENSG00000185010 E019 9.6404846 0.001842456 9.461215e-07 7.888038e-06 X 154930153 154931676 1524 - 1.100 0.332 -3.335
ENSG00000185010 E020 3.3067653 0.017524078 9.511572e-01 9.734474e-01 X 154947698 154947907 210 - 0.596 0.589 -0.032
ENSG00000185010 E021 2.4390651 0.007069063 8.377391e-01 8.985780e-01 X 154953892 154954042 151 - 0.481 0.519 0.185
ENSG00000185010 E022 2.0035365 0.007410384 1.163319e-01 2.147222e-01 X 154956957 154957171 215 - 0.507 0.197 -1.941
ENSG00000185010 E023 1.0371996 0.023596080 9.793281e-02 1.873670e-01 X 154961075 154961168 94 - 0.360 0.000 -12.665
ENSG00000185010 E024 0.1482932 0.042031022 1.485740e-01   X 154965772 154965969 198 - 0.000 0.197 12.326
ENSG00000185010 E025 3.1064115 0.005290915 6.361312e-01 7.502296e-01 X 154965970 154966141 172 - 0.596 0.519 -0.357
ENSG00000185010 E026 3.1128560 0.005313427 9.941874e-02 1.895972e-01 X 154966426 154966687 262 - 0.635 0.333 -1.526
ENSG00000185010 E027 3.2860396 0.004811119 9.472303e-01 9.708479e-01 X 154969331 154969552 222 - 0.596 0.588 -0.035
ENSG00000185010 E028 0.1482932 0.042031022 1.485740e-01   X 154977352 154977441 90 - 0.000 0.197 12.326
ENSG00000185010 E029 2.3314552 0.007156319 1.323506e-01 2.373703e-01 X 154984687 154984700 14 - 0.393 0.649 1.229
ENSG00000185010 E030 4.3911126 0.005280133 1.302363e-03 4.984924e-03 X 154984701 154984803 103 - 0.506 0.957 1.867
ENSG00000185010 E031 3.3549477 0.005421028 1.361952e-02 3.735381e-02 X 154987237 154987305 69 - 0.454 0.830 1.644
ENSG00000185010 E032 3.6409275 0.005576239 1.195828e-01 2.193683e-01 X 154992936 154993024 89 - 0.554 0.791 1.005
ENSG00000185010 E033 4.5609522 0.060571954 1.022061e-01 1.938707e-01 X 154993025 154993148 124 - 0.615 0.895 1.131
ENSG00000185010 E034 5.3657588 0.003220097 2.930031e-01 4.340472e-01 X 154996973 154997095 123 - 0.719 0.865 0.579
ENSG00000185010 E035 5.3853241 0.003507733 5.584005e-02 1.194149e-01 X 154999479 154999600 122 - 0.670 0.928 1.022
ENSG00000185010 E036 0.2924217 0.030154898 7.453887e-01   X 155022410 155022431 22 - 0.136 0.000 -11.270
ENSG00000185010 E037 0.8470867 0.014750189 4.445314e-01 5.860850e-01 X 155022432 155022496 65 - 0.191 0.333 1.060
ENSG00000185010 E038 0.1515154 0.042332737 1.000000e+00   X 155022497 155022723 227 - 0.073 0.000 -10.414
ENSG00000185010 E039 3.3685767 0.090570293 1.318553e-02 3.634134e-02 X 155026780 155026940 161 - 0.425 0.868 1.938