ENSG00000185009

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355264 ENSG00000185009 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3M1 protein_coding protein_coding 26.76661 16.01251 33.41676 1.579791 0.9010724 1.060903 5.585123 5.013692 6.729305 0.7900974 0.3291519 0.4238519 0.2313792 0.31363333 0.2019333 -0.1117000 7.895374e-02 3.977719e-07 FALSE TRUE
ENST00000372745 ENSG00000185009 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3M1 protein_coding protein_coding 26.76661 16.01251 33.41676 1.579791 0.9010724 1.060903 8.595670 1.436649 12.900107 0.4837743 0.6093814 3.1577142 0.2691917 0.08693333 0.3856667 0.2987333 3.977719e-07 3.977719e-07 FALSE TRUE
MSTRG.4211.2 ENSG00000185009 HEK293_OSMI2_2hA HEK293_TMG_2hB AP3M1 protein_coding   26.76661 16.01251 33.41676 1.579791 0.9010724 1.060903 11.944023 9.126268 13.067731 0.8378888 0.3331974 0.5174353 0.4744833 0.57146667 0.3911000 -0.1803667 5.393713e-07 3.977719e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185009 E001 177.839490 0.0122708853 2.195982e-05 1.348401e-04 10 74120255 74121758 1504 - 2.093 2.413 1.068
ENSG00000185009 E002 803.658371 0.0035659956 6.866160e-24 6.743253e-22 10 74121759 74122963 1205 - 2.745 3.065 1.062
ENSG00000185009 E003 513.558577 0.0001164532 1.959076e-06 1.527015e-05 10 74122964 74123771 808 - 2.643 2.783 0.464
ENSG00000185009 E004 235.220648 0.0025962863 5.749352e-02 1.223281e-01 10 74123772 74123910 139 - 2.360 2.358 -0.006
ENSG00000185009 E005 217.681238 0.0008769484 8.046210e-06 5.459831e-05 10 74124380 74124524 145 - 2.347 2.287 -0.201
ENSG00000185009 E006 271.348667 0.0007676332 9.977419e-09 1.230994e-07 10 74126148 74126355 208 - 2.450 2.370 -0.265
ENSG00000185009 E007 1.329517 0.3678048402 2.574661e-01 3.945846e-01 10 74128878 74129107 230 - 0.225 0.521 1.769
ENSG00000185009 E008 201.046345 0.0001930963 2.765264e-10 4.526275e-09 10 74129108 74129241 134 - 2.327 2.228 -0.330
ENSG00000185009 E009 151.569843 0.0002338813 5.727968e-11 1.052620e-09 10 74129907 74129992 86 - 2.215 2.081 -0.449
ENSG00000185009 E010 1.146895 0.0113392856 7.210157e-01 8.155222e-01 10 74129993 74130004 12 - 0.281 0.380 0.625
ENSG00000185009 E011 175.838624 0.0007038690 4.223345e-13 1.099340e-11 10 74134027 74134164 138 - 2.286 2.130 -0.521
ENSG00000185009 E012 203.537010 0.0040983546 3.599245e-06 2.647407e-05 10 74136632 74136803 172 - 2.338 2.217 -0.406
ENSG00000185009 E013 183.472159 0.0005870429 5.721121e-07 5.005538e-06 10 74138107 74138255 149 - 2.280 2.202 -0.264
ENSG00000185009 E014 150.791375 0.0002354809 3.304125e-10 5.339105e-09 10 74138256 74138382 127 - 2.211 2.086 -0.420
ENSG00000185009 E015 86.306148 0.0003274862 4.479142e-08 4.877062e-07 10 74138806 74138931 126 - 1.981 1.825 -0.525
ENSG00000185009 E016 5.154442 0.0338599432 9.787748e-01 9.908090e-01 10 74150335 74150464 130 - 0.761 0.818 0.226
ENSG00000185009 E017 2.086730 0.2277008481 7.611033e-01 8.450276e-01 10 74150465 74150495 31 - 0.513 0.449 -0.316
ENSG00000185009 E018 4.452438 0.0037318289 2.784572e-01 4.181278e-01 10 74150496 74150754 259 - 0.644 0.849 0.832
ENSG00000185009 E019 100.444664 0.0002915690 3.661221e-08 4.052391e-07 10 74150755 74151005 251 - 2.040 1.900 -0.472