ENSG00000185008

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332191 ENSG00000185008 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO2 protein_coding protein_coding 1.65671 1.065305 2.355825 0.07156779 0.04504305 1.137597 0.110398982 0.03579377 0.1399359 0.01827733 0.05050246 1.71112271 0.061641667 0.03230000 0.06023333 0.02793333 0.6725133019 0.0008602789 FALSE TRUE
ENST00000490991 ENSG00000185008 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO2 protein_coding protein_coding 1.65671 1.065305 2.355825 0.07156779 0.04504305 1.137597 0.406430632 0.46240917 0.4933132 0.08855848 0.21230876 0.09141949 0.282437500 0.43090000 0.20763333 -0.22326667 0.3045969258 0.0008602789 FALSE TRUE
ENST00000602589 ENSG00000185008 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO2 protein_coding protein_coding 1.65671 1.065305 2.355825 0.07156779 0.04504305 1.137597 0.467366364 0.02721448 0.9351032 0.02721448 0.21436404 4.66653602 0.223083333 0.02600000 0.39923333 0.37323333 0.0008602789 0.0008602789 FALSE TRUE
ENST00000696593 ENSG00000185008 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO2 protein_coding protein_coding 1.65671 1.065305 2.355825 0.07156779 0.04504305 1.137597 0.520915972 0.41475242 0.6602403 0.03717805 0.10997342 0.65805623 0.327975000 0.38820000 0.27893333 -0.10926667 0.4222236111 0.0008602789 FALSE TRUE
MSTRG.23272.10 ENSG00000185008 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO2 protein_coding   1.65671 1.065305 2.355825 0.07156779 0.04504305 1.137597 0.006556692 0.05245354 0.0000000 0.05245354 0.00000000 -2.64278326 0.006266667 0.05013333 0.00000000 -0.05013333 0.5829335820 0.0008602789 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000185008 E001 0.0000000       3 75906695 75906704 10 +      
ENSG00000185008 E002 0.0000000       3 75906705 75906801 97 +      
ENSG00000185008 E003 0.5181333 0.0200643211 9.769160e-01 9.895878e-01 3 75906802 75906960 159 + 0.161 0.168 0.078
ENSG00000185008 E004 0.6653823 0.0170951115 7.654642e-01 8.482337e-01 3 75937481 75937602 122 + 0.223 0.168 -0.507
ENSG00000185008 E005 0.0000000       3 76311096 76311417 322 +      
ENSG00000185008 E006 0.1515154 0.0422920202 1.000000e+00   3 77039886 77040098 213 + 0.088 0.000 -10.263
ENSG00000185008 E007 1.4017412 0.0096570922 1.436326e-01 2.529492e-01 3 77040099 77040146 48 + 0.446 0.168 -1.923
ENSG00000185008 E008 16.6799407 0.0299412074 3.248980e-02 7.678689e-02 3 77040147 77040675 529 + 1.308 1.041 -0.952
ENSG00000185008 E009 6.4052503 0.0028226990 1.537912e-01 2.668238e-01 3 77040676 77040729 54 + 0.912 0.720 -0.754
ENSG00000185008 E010 8.9913714 0.0025430904 5.676487e-01 6.944250e-01 3 77040730 77040846 117 + 0.958 1.019 0.228
ENSG00000185008 E011 18.5839997 0.0050156713 3.999821e-01 5.437073e-01 3 77098014 77098340 327 + 1.297 1.221 -0.269
ENSG00000185008 E012 13.8404080 0.0020802572 2.302502e-01 3.627581e-01 3 77477414 77477571 158 + 1.192 1.075 -0.422
ENSG00000185008 E013 13.1943595 0.0180969600 3.767604e-02 8.672360e-02 3 77481099 77481219 121 + 1.210 0.957 -0.918
ENSG00000185008 E014 14.1462007 0.0013339084 1.765419e-03 6.489327e-03 3 77493244 77493382 139 + 1.251 0.933 -1.152
ENSG00000185008 E015 10.7792930 0.0017083026 4.723775e-03 1.516069e-02 3 77522775 77522902 128 + 1.146 0.824 -1.197
ENSG00000185008 E016 3.6954207 0.0326337447 1.152335e-01 2.131981e-01 3 77527403 77527414 12 + 0.739 0.461 -1.245
ENSG00000185008 E017 9.3910659 0.0283318158 1.820707e-01 3.038071e-01 3 77546338 77546462 125 + 1.062 0.880 -0.677
ENSG00000185008 E018 12.4761705 0.0400803298 2.769244e-01 4.164218e-01 3 77550818 77550989 172 + 1.166 1.016 -0.543
ENSG00000185008 E019 10.4681426 0.0026085611 5.107988e-01 6.459642e-01 3 77557944 77558149 206 + 1.070 0.999 -0.262
ENSG00000185008 E020 6.9323794 0.0025686789 7.213057e-01 8.157382e-01 3 77562651 77562732 82 + 0.900 0.854 -0.178
ENSG00000185008 E021 4.5665680 0.0038262216 3.541621e-01 4.984284e-01 3 77563167 77563179 13 + 0.773 0.634 -0.576
ENSG00000185008 E022 8.2045629 0.0611274411 6.619701e-01 7.703398e-01 3 77563180 77563329 150 + 0.967 0.890 -0.292
ENSG00000185008 E023 0.0000000       3 77564450 77564588 139 +      
ENSG00000185008 E024 11.3829685 0.0501337205 2.627640e-01 4.005687e-01 3 77564954 77565120 167 + 1.117 0.966 -0.551
ENSG00000185008 E025 9.1307305 0.0023088275 4.622777e-01 6.021281e-01 3 77568313 77568434 122 + 1.018 0.933 -0.316
ENSG00000185008 E026 12.0481009 0.0015677656 5.079929e-01 6.434336e-01 3 77574499 77574730 232 + 1.125 1.057 -0.246
ENSG00000185008 E027 9.4798857 0.0018439381 2.014327e-01 3.279743e-01 3 77577490 77577614 125 + 1.053 0.908 -0.541
ENSG00000185008 E028 12.5577276 0.0015041204 5.217040e-01 6.555932e-01 3 77579947 77580118 172 + 1.139 1.074 -0.233
ENSG00000185008 E029 7.1589102 0.0024704756 3.777696e-01 5.220691e-01 3 77588751 77588780 30 + 0.936 0.824 -0.427
ENSG00000185008 E030 14.4785326 0.0013508828 4.280897e-01 5.709038e-01 3 77588781 77588933 153 + 1.198 1.123 -0.268
ENSG00000185008 E031 8.5379736 0.0020841642 6.996603e-01 7.993086e-01 3 77595142 77595184 43 + 0.979 0.932 -0.172
ENSG00000185008 E032 11.0557397 0.0017329937 8.448456e-01 9.034522e-01 3 77596623 77596750 128 + 1.079 1.057 -0.080
ENSG00000185008 E033 15.3981244 0.0236355149 2.239094e-01 3.550824e-01 3 77602210 77602482 273 + 1.152 1.277 0.441
ENSG00000185008 E034 3.6838760 0.0047295848 3.891615e-01 5.332726e-01 3 77602483 77602491 9 + 0.593 0.721 0.547
ENSG00000185008 E035 0.0000000       3 77602935 77603060 126 +      
ENSG00000185008 E036 0.0000000       3 77603744 77603951 208 +      
ENSG00000185008 E037 0.1482932 0.0418782359 2.319202e-01   3 77603952 77604041 90 + 0.000 0.168 10.670
ENSG00000185008 E038 10.2378294 0.0018379689 2.158527e-02 5.481955e-02 3 77607798 77607954 157 + 0.936 1.167 0.846
ENSG00000185008 E039 16.1298652 0.0327828959 1.641636e-01 2.805874e-01 3 77617513 77617773 261 + 1.154 1.317 0.577
ENSG00000185008 E040 5.8651526 0.1340147601 3.735273e-01 5.179626e-01 3 77617774 77618180 407 + 0.758 0.910 0.590
ENSG00000185008 E041 10.6753882 0.0016704904 5.153855e-01 6.500635e-01 3 77622227 77622432 206 + 1.027 1.091 0.235
ENSG00000185008 E042 0.1515154 0.0422920202 1.000000e+00   3 77629122 77632473 3352 + 0.088 0.000 -10.263
ENSG00000185008 E043 2.1682890 0.0072943071 1.297041e-01 2.337368e-01 3 77632474 77632656 183 + 0.567 0.289 -1.508
ENSG00000185008 E044 0.1472490 0.0431955447 1.000000e+00   3 77632657 77634869 2213 + 0.088 0.000 -10.260
ENSG00000185008 E045 9.0649639 0.0019121334 9.361474e-01 9.638289e-01 3 77634870 77635043 174 + 0.989 0.978 -0.039
ENSG00000185008 E046 6.1201253 0.0546887847 7.881040e-01 8.642976e-01 3 77642671 77642943 273 + 0.821 0.856 0.136
ENSG00000185008 E047 9.9772855 0.0020073319 1.461206e-01 2.564132e-01 3 77644704 77644895 192 + 0.958 1.108 0.550
ENSG00000185008 E048 2.7356358 0.1990886475 1.776340e-01 2.981636e-01 3 77644896 77644904 9 + 0.410 0.726 1.464
ENSG00000185008 E049 58.0349459 0.0004730415 8.926035e-17 3.869589e-15 3 77646054 77649964 3911 + 1.582 1.942 1.217