ENSG00000184949

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355830 ENSG00000184949 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM227A protein_coding protein_coding 1.265425 0.6191087 1.323956 0.137269 0.1064883 1.08433 0.01295908 0.02712097 0.00000000 0.02712097 0.00000000 -1.892234 0.01370000 0.05976667 0.00000000 -0.05976667 0.558551064 0.002632372 FALSE TRUE
ENST00000535113 ENSG00000184949 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM227A protein_coding protein_coding 1.265425 0.6191087 1.323956 0.137269 0.1064883 1.08433 0.23453178 0.27707614 0.00000000 0.11816996 0.00000000 -4.843361 0.25144583 0.45303333 0.00000000 -0.45303333 0.006685921 0.002632372 FALSE TRUE
ENST00000540952 ENSG00000184949 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM227A protein_coding protein_coding 1.265425 0.6191087 1.323956 0.137269 0.1064883 1.08433 0.43450267 0.06515931 0.79414584 0.06515931 0.05936955 3.419434 0.31989583 0.14360000 0.60046667 0.45686667 0.098975257 0.002632372 FALSE TRUE
ENST00000543828 ENSG00000184949 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM227A protein_coding processed_transcript 1.265425 0.6191087 1.323956 0.137269 0.1064883 1.08433 0.17833769 0.13243561 0.04172845 0.13243561 0.04172845 -1.461280 0.12949583 0.14853333 0.03146667 -0.11706667 0.847454653 0.002632372   FALSE
MSTRG.22120.6 ENSG00000184949 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM227A protein_coding   1.265425 0.6191087 1.323956 0.137269 0.1064883 1.08433 0.15654978 0.00000000 0.34635788 0.00000000 0.07553993 5.155255 0.09441667 0.00000000 0.27406667 0.27406667 0.002632372 0.002632372 TRUE TRUE
MSTRG.22120.7 ENSG00000184949 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM227A protein_coding   1.265425 0.6191087 1.323956 0.137269 0.1064883 1.08433 0.20427225 0.09594421 0.14172353 0.04899695 0.14172353 0.518140 0.15838333 0.15330000 0.09403333 -0.05926667 0.629303378 0.002632372 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184949 E001 0.1482932 0.0417466595 0.2306245   22 38578118 38578119 2 - 0.000 0.169 10.261
ENSG00000184949 E002 46.4538110 0.0005406810 0.8592570 0.91319645 22 38578120 38582168 4049 - 1.650 1.660 0.037
ENSG00000184949 E003 5.9202240 0.0031815151 0.9597649 0.97870388 22 38582169 38582338 170 - 0.832 0.827 -0.020
ENSG00000184949 E004 6.3524035 0.0059641151 0.2966509 0.43790669 22 38582339 38582401 63 - 0.802 0.935 0.510
ENSG00000184949 E005 13.2608904 0.0133930340 0.0764623 0.15384140 22 38582402 38582861 460 - 1.051 1.238 0.670
ENSG00000184949 E006 5.5866228 0.0292813598 0.3824491 0.52666115 22 38582862 38582917 56 - 0.753 0.884 0.513
ENSG00000184949 E007 7.7290144 0.0171200819 0.7223927 0.81650935 22 38582918 38583044 127 - 0.909 0.958 0.184
ENSG00000184949 E008 55.4753881 0.0005281279 0.9109388 0.94742099 22 38583045 38585874 2830 - 1.730 1.727 -0.010
ENSG00000184949 E009 4.8970567 0.0417399149 0.8365185 0.89778388 22 38585875 38585969 95 - 0.737 0.763 0.105
ENSG00000184949 E010 5.8659052 0.0030501791 0.1789691 0.29985726 22 38585970 38586064 95 - 0.737 0.911 0.683
ENSG00000184949 E011 8.3894624 0.0020069809 0.3225409 0.46583773 22 38586065 38586199 135 - 0.910 1.022 0.418
ENSG00000184949 E012 3.1073685 0.2490695723 0.5585350 0.68676596 22 38591361 38591433 73 - 0.637 0.567 -0.309
ENSG00000184949 E013 1.1865370 0.0112795797 0.6676975 0.77486299 22 38591434 38591434 1 - 0.368 0.290 -0.491
ENSG00000184949 E014 7.1819908 0.0181990573 0.5414482 0.67243379 22 38591435 38591540 106 - 0.933 0.854 -0.300
ENSG00000184949 E015 4.1318932 0.0059220995 0.8874179 0.93204563 22 38597204 38597206 3 - 0.699 0.722 0.094
ENSG00000184949 E016 6.9364197 0.0043748555 0.4391098 0.58088951 22 38597207 38597356 150 - 0.921 0.826 -0.364
ENSG00000184949 E017 6.4407378 0.0026873525 0.1562783 0.27016634 22 38599764 38599921 158 - 0.910 0.723 -0.733
ENSG00000184949 E018 5.5989576 0.0198423343 0.6836210 0.78677572 22 38605254 38605348 95 - 0.771 0.829 0.228
ENSG00000184949 E019 4.9135029 0.0035868651 0.8726292 0.92207174 22 38607389 38607476 88 - 0.737 0.761 0.098
ENSG00000184949 E020 0.0000000       22 38618396 38618543 148 -      
ENSG00000184949 E021 2.5704195 0.0766114486 0.9423373 0.96776332 22 38620212 38620215 4 - 0.537 0.531 -0.028
ENSG00000184949 E022 5.0294447 0.0034566120 0.6401905 0.75347391 22 38620216 38620291 76 - 0.787 0.723 -0.257
ENSG00000184949 E023 7.5091691 0.0024462744 0.3375083 0.48139218 22 38623172 38623279 108 - 0.944 0.827 -0.447
ENSG00000184949 E024 7.5127394 0.0047032708 0.7661741 0.84874247 22 38626180 38626303 124 - 0.898 0.935 0.143
ENSG00000184949 E025 1.2491791 0.3520934448 0.7543243 0.83999198 22 38628238 38628342 105 - 0.276 0.400 0.771
ENSG00000184949 E026 5.5025030 0.0031925940 0.0375466 0.08649082 22 38628834 38628935 102 - 0.885 0.586 -1.226
ENSG00000184949 E027 0.1472490 0.0428280458 1.0000000   22 38628936 38629002 67 - 0.087 0.000 -12.157
ENSG00000184949 E028 5.4368502 0.0031516492 0.2358454 0.36937701 22 38636451 38636545 95 - 0.846 0.682 -0.659
ENSG00000184949 E029 2.6668676 0.0508559401 0.5063966 0.64205327 22 38636546 38636556 11 - 0.591 0.463 -0.603
ENSG00000184949 E030 2.9946751 0.0052048357 0.9720837 0.98655461 22 38636557 38636597 41 - 0.590 0.586 -0.019
ENSG00000184949 E031 2.7419968 0.0056364302 0.1436523 0.25297693 22 38638746 38638771 26 - 0.637 0.385 -1.226
ENSG00000184949 E032 3.5492409 0.0051171438 0.8760589 0.92441005 22 38638772 38638822 51 - 0.659 0.636 -0.097
ENSG00000184949 E033 1.4477612 0.4476004325 0.2682724 0.40671739 22 38639615 38639654 40 - 0.278 0.522 1.373
ENSG00000184949 E034 4.3252388 0.0039534088 0.9854343 0.99491490 22 38639655 38639724 70 - 0.718 0.723 0.017
ENSG00000184949 E035 5.1283183 0.0034655566 0.8685406 0.91949333 22 38645563 38645645 83 - 0.771 0.795 0.095
ENSG00000184949 E036 0.1515154 0.0419273338 1.0000000   22 38649945 38650026 82 - 0.087 0.000 -12.160
ENSG00000184949 E037 8.1271330 0.0021469323 0.9116201 0.94791093 22 38650027 38650262 236 - 0.944 0.958 0.054
ENSG00000184949 E038 0.1515154 0.0419273338 1.0000000   22 38653810 38653853 44 - 0.087 0.000 -12.160
ENSG00000184949 E039 5.5075981 0.0035712834 0.3606141 0.50494141 22 38656120 38656629 510 - 0.846 0.723 -0.490