ENSG00000184939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000563169 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding protein_coding 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.4321568 0.09178279 0.4270075 0.04605768 0.42700747 2.1021643 0.07165417 0.02130000 0.05640000 0.03510000 7.727779e-01 6.477619e-11 FALSE TRUE
ENST00000564323 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding protein_coding 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.5007036 0.86407049 0.6495961 0.03452181 0.36144984 -0.4061667 0.09935833 0.21470000 0.08876667 -0.12593333 5.031579e-01 6.477619e-11 FALSE TRUE
ENST00000569323 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding nonsense_mediated_decay 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.3667838 0.24767464 0.5637950 0.12516432 0.28315904 1.1549849 0.05772500 0.05493333 0.07740000 0.02246667 1.000000e+00 6.477619e-11 FALSE TRUE
ENST00000570495 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding protein_coding 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.2362614 0.00000000 0.4505376 0.00000000 0.22545472 5.5252471 0.04344583 0.00000000 0.06176667 0.06176667 2.734361e-01 6.477619e-11 FALSE TRUE
ENST00000571720 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding retained_intron 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.3613658 0.04063393 0.5400856 0.02048663 0.04156254 3.4414796 0.05370833 0.00940000 0.07313333 0.06373333 2.977164e-04 6.477619e-11 FALSE TRUE
ENST00000573161 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding protein_coding 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.2653699 0.44632969 0.2368617 0.44632969 0.23686174 -0.8863733 0.05011250 0.12120000 0.03130000 -0.08990000 9.617271e-01 6.477619e-11   FALSE
ENST00000573685 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding protein_coding 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.3683360 0.00000000 1.1903317 0.00000000 0.13881968 6.9072893 0.06257917 0.00000000 0.16246667 0.16246667 6.477619e-11 6.477619e-11 FALSE TRUE
ENST00000611381 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding protein_coding 5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.3817623 0.38140110 0.2072382 0.19718425 0.20723823 -0.8493698 0.07337500 0.09150000 0.02736667 -0.06413333 5.408236e-01 6.477619e-11 FALSE FALSE
MSTRG.12869.16 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding   5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 0.6729483 1.32906988 0.2213047 0.82415349 0.12670496 -2.5333649 0.14762917 0.29090000 0.03020000 -0.26070000 5.603267e-01 6.477619e-11   FALSE
MSTRG.12869.3 ENSG00000184939 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFP90 protein_coding   5.740211 4.140697 7.366315 0.4687842 0.1617009 0.8295467 1.1480370 0.37567983 1.8927689 0.16725766 0.40558836 2.3026248 0.17293333 0.10130000 0.25766667 0.15636667 3.362187e-01 6.477619e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184939 E001 0.0000000       16 68530090 68530117 28 +      
ENSG00000184939 E002 3.6955464 0.004175390 6.682351e-01 7.752880e-01 16 68530118 68530147 30 + 0.705 0.581 -0.537
ENSG00000184939 E003 7.0817324 0.004716897 6.722321e-01 7.782709e-01 16 68530148 68530283 136 + 0.939 0.820 -0.455
ENSG00000184939 E004 6.4247560 0.002690182 6.920030e-01 7.933402e-01 16 68530284 68530334 51 + 0.904 0.789 -0.447
ENSG00000184939 E005 0.0000000       16 68530335 68530534 200 +      
ENSG00000184939 E006 9.5163301 0.002510969 7.903085e-01 8.658430e-01 16 68533698 68533855 158 + 1.048 0.952 -0.357
ENSG00000184939 E007 0.1515154 0.042477632 1.000000e+00   16 68539213 68539290 78 + 0.089 0.000 -9.401
ENSG00000184939 E008 0.1515154 0.042477632 1.000000e+00   16 68539291 68539296 6 + 0.089 0.000 -9.401
ENSG00000184939 E009 5.5940203 0.003028491 3.816113e-03 1.262576e-02 16 68539297 68539313 17 + 0.665 0.974 1.219
ENSG00000184939 E010 6.4453734 0.002677110 3.806862e-03 1.260000e-02 16 68539314 68539315 2 + 0.724 1.016 1.123
ENSG00000184939 E011 7.9651302 0.002082284 8.431078e-03 2.486482e-02 16 68539316 68539322 7 + 0.838 1.071 0.872
ENSG00000184939 E012 9.3313798 0.001925644 1.028302e-03 4.056401e-03 16 68539323 68539324 2 + 0.865 1.150 1.050
ENSG00000184939 E013 15.1199512 0.020184612 4.299923e-04 1.889997e-03 16 68539325 68539378 54 + 1.040 1.350 1.103
ENSG00000184939 E014 17.8038913 0.014604155 5.812730e-05 3.222534e-04 16 68539379 68539429 51 + 1.106 1.423 1.117
ENSG00000184939 E015 14.4767681 0.024959308 1.574220e-04 7.802606e-04 16 68539430 68539469 40 + 1.012 1.362 1.247
ENSG00000184939 E016 4.6852640 0.160824690 3.563352e-01 5.007168e-01 16 68539470 68539479 10 + 0.837 0.520 -1.345
ENSG00000184939 E017 2.3699415 0.093801624 4.877131e-02 1.069767e-01 16 68539480 68539487 8 + 0.643 0.166 -2.867
ENSG00000184939 E018 2.5055546 0.080229852 8.915724e-04 3.584727e-03 16 68539703 68539757 55 + 0.225 0.792 2.938
ENSG00000184939 E019 17.5163480 0.033839178 8.599237e-06 5.801017e-05 16 68539758 68539794 37 + 1.031 1.474 1.565
ENSG00000184939 E020 16.3612779 0.001844858 2.862307e-07 2.660724e-06 16 68539795 68539825 31 + 1.049 1.412 1.286
ENSG00000184939 E021 5.5144186 0.031124893 7.975271e-08 8.257589e-07 16 68555073 68555240 168 + 0.372 1.119 3.164
ENSG00000184939 E022 0.1472490 0.043008724 1.000000e+00   16 68557173 68557291 119 + 0.089 0.000 -9.398
ENSG00000184939 E023 11.6702332 0.032314237 9.400082e-01 9.663282e-01 16 68557998 68558004 7 + 1.114 1.036 -0.283
ENSG00000184939 E024 16.0931427 0.004440306 2.214632e-01 3.521591e-01 16 68558005 68558039 35 + 1.276 1.088 -0.670
ENSG00000184939 E025 22.4403309 0.001077367 2.091663e-02 5.341429e-02 16 68558040 68558124 85 + 1.435 1.177 -0.903
ENSG00000184939 E026 0.1515154 0.042477632 1.000000e+00   16 68558125 68558172 48 + 0.089 0.000 -9.401
ENSG00000184939 E027 3.3405447 0.005180730 2.373158e-02 5.925997e-02 16 68558375 68558472 98 + 0.742 0.287 -2.273
ENSG00000184939 E028 23.4245384 0.001074508 1.421424e-02 3.871254e-02 16 68558473 68558568 96 + 1.456 1.190 -0.929
ENSG00000184939 E029 7.0139305 0.002426568 3.279886e-03 1.109124e-02 16 68562061 68562988 928 + 1.012 0.524 -1.986
ENSG00000184939 E030 3.9493481 0.004027239 3.439695e-02 8.051596e-02 16 68562989 68563043 55 + 0.793 0.381 -1.890
ENSG00000184939 E031 395.9932515 0.009919954 1.435494e-06 1.152673e-05 16 68563044 68567136 4093 + 2.644 2.456 -0.627
ENSG00000184939 E032 4.7154969 0.004351975 2.812079e-04 1.303307e-03 16 68575791 68576072 282 + 0.543 0.974 1.758