ENSG00000184922

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331495 ENSG00000184922 HEK293_OSMI2_2hA HEK293_TMG_2hB FMNL1 protein_coding protein_coding 0.8149028 1.512915 0.6560242 0.289026 0.04800203 -1.193189 0.30565670 0.48679503 0.30340154 0.05528471 0.04355849 -0.6646385 0.41395833 0.34850000 0.4754667 0.12696667 0.612085133 0.008447623 FALSE TRUE
ENST00000585852 ENSG00000184922 HEK293_OSMI2_2hA HEK293_TMG_2hB FMNL1 protein_coding retained_intron 0.8149028 1.512915 0.6560242 0.289026 0.04800203 -1.193189 0.03024989 0.03601355 0.02347812 0.03601355 0.02347812 -0.4588403 0.05197917 0.01723333 0.0403000 0.02306667 0.877764113 0.008447623 FALSE FALSE
ENST00000586643 ENSG00000184922 HEK293_OSMI2_2hA HEK293_TMG_2hB FMNL1 protein_coding protein_coding 0.8149028 1.512915 0.6560242 0.289026 0.04800203 -1.193189 0.02993721 0.00000000 0.03956587 0.00000000 0.03956587 2.3093470 0.05741667 0.00000000 0.0530000 0.05300000 0.589179077 0.008447623 FALSE TRUE
ENST00000587489 ENSG00000184922 HEK293_OSMI2_2hA HEK293_TMG_2hB FMNL1 protein_coding protein_coding 0.8149028 1.512915 0.6560242 0.289026 0.04800203 -1.193189 0.26171978 0.62762893 0.09026773 0.08256860 0.02701975 -2.6688597 0.25562917 0.42496667 0.1406667 -0.28430000 0.008447623 0.008447623 FALSE TRUE
ENST00000592006 ENSG00000184922 HEK293_OSMI2_2hA HEK293_TMG_2hB FMNL1 protein_coding processed_transcript 0.8149028 1.512915 0.6560242 0.289026 0.04800203 -1.193189 0.13056444 0.27271914 0.10219794 0.14088295 0.10219794 -1.3333234 0.13921250 0.16630000 0.1369333 -0.02936667 0.781888661 0.008447623 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184922 E001 0.1817044 0.039551074 1.00000000   17 45221444 45221646 203 + 0.000 0.081 8.830
ENSG00000184922 E002 0.5169874 0.020615548 0.86380751 0.91619773 17 45221885 45221907 23 + 0.181 0.149 -0.330
ENSG00000184922 E003 1.9457059 0.007977857 0.90635719 0.94449078 17 45221908 45222253 346 + 0.406 0.422 0.086
ENSG00000184922 E004 1.9467500 0.007635938 0.41636426 0.55972971 17 45230604 45230668 65 + 0.308 0.454 0.840
ENSG00000184922 E005 1.9812079 0.007880630 0.34640809 0.49053312 17 45230669 45230687 19 + 0.554 0.387 -0.845
ENSG00000184922 E006 0.0000000       17 45231427 45231440 14 +      
ENSG00000184922 E007 4.5901312 0.003774098 0.61079689 0.73007293 17 45232367 45232450 84 + 0.752 0.672 -0.330
ENSG00000184922 E008 3.4957508 0.004877972 0.55302537 0.68224529 17 45232451 45232480 30 + 0.664 0.565 -0.436
ENSG00000184922 E009 0.0000000       17 45232862 45233223 362 +      
ENSG00000184922 E010 5.7434433 0.003489452 0.19500603 0.31998846 17 45233224 45233297 74 + 0.887 0.708 -0.707
ENSG00000184922 E011 4.0190809 0.004323361 0.53932568 0.67061704 17 45233648 45233731 84 + 0.710 0.611 -0.422
ENSG00000184922 E012 0.2998086 0.030938913 0.50640733   17 45233732 45233883 152 + 0.181 0.081 -1.334
ENSG00000184922 E013 0.1482932 0.042886243 1.00000000   17 45233884 45234071 188 + 0.000 0.081 9.214
ENSG00000184922 E014 1.9583782 0.016821375 0.90428232 0.94306586 17 45234072 45234079 8 + 0.406 0.422 0.087
ENSG00000184922 E015 4.7404981 0.003611910 0.21645707 0.34614823 17 45234080 45234200 121 + 0.554 0.742 0.807
ENSG00000184922 E016 0.2955422 0.029091491 0.50931514   17 45234201 45234687 487 + 0.181 0.081 -1.333
ENSG00000184922 E017 0.8041237 0.014849741 0.59585608 0.71787828 17 45234832 45234849 18 + 0.308 0.208 -0.746
ENSG00000184922 E018 4.4544086 0.003813502 0.82784187 0.89178598 17 45236136 45236244 109 + 0.664 0.690 0.110
ENSG00000184922 E019 0.3332198 0.030663680 0.50613202   17 45236245 45236594 350 + 0.181 0.081 -1.331
ENSG00000184922 E020 6.2632882 0.010887963 0.97657409 0.98936898 17 45237281 45237357 77 + 0.825 0.814 -0.041
ENSG00000184922 E021 7.8193101 0.010568097 0.64278725 0.75550223 17 45237546 45237639 94 + 0.942 0.878 -0.240
ENSG00000184922 E022 8.0750733 0.013662538 0.26896745 0.40743527 17 45238564 45238638 75 + 1.012 0.866 -0.549
ENSG00000184922 E023 8.2446734 0.002410563 0.08839505 0.17266452 17 45238955 45239065 111 + 1.054 0.855 -0.746
ENSG00000184922 E024 8.5969824 0.002406644 0.05824435 0.12361606 17 45240476 45240625 150 + 1.073 0.855 -0.816
ENSG00000184922 E025 0.2944980 0.171248133 0.06873842   17 45240626 45241074 449 + 0.308 0.000 -13.145
ENSG00000184922 E026 0.0000000       17 45241075 45241128 54 +      
ENSG00000184922 E027 7.4147369 0.046381497 0.84284107 0.90208588 17 45241129 45241230 102 + 0.887 0.857 -0.117
ENSG00000184922 E028 0.0000000       17 45241231 45241381 151 +      
ENSG00000184922 E029 6.4516223 0.003125117 0.54074450 0.67185489 17 45241382 45241634 253 + 0.752 0.829 0.307
ENSG00000184922 E030 0.0000000       17 45241635 45241846 212 +      
ENSG00000184922 E031 4.4180648 0.011027945 0.73778844 0.82786528 17 45241847 45242146 300 + 0.710 0.653 -0.238
ENSG00000184922 E032 6.2487233 0.002873096 0.04174396 0.09426387 17 45242341 45242465 125 + 0.554 0.855 1.255
ENSG00000184922 E033 10.5236333 0.002141592 0.65139970 0.76227659 17 45243118 45243320 203 + 0.967 1.010 0.162
ENSG00000184922 E034 11.2191795 0.001703013 0.72835313 0.82083197 17 45243791 45244025 235 + 1.054 1.010 -0.160
ENSG00000184922 E035 0.0000000       17 45244026 45244175 150 +      
ENSG00000184922 E036 6.4907976 0.003649011 0.98749384 0.99626553 17 45244176 45244244 69 + 0.825 0.816 -0.035
ENSG00000184922 E037 7.1153052 0.004784832 0.70787957 0.80565715 17 45244819 45244899 81 + 0.825 0.867 0.164
ENSG00000184922 E038 10.1485425 0.001912133 0.26224196 0.40000767 17 45244979 45245108 130 + 0.887 1.010 0.461
ENSG00000184922 E039 7.5469055 0.002476766 0.11953455 0.21929252 17 45245253 45245323 71 + 0.710 0.913 0.799
ENSG00000184922 E040 2.8397194 0.013637530 0.96657852 0.98304327 17 45245324 45245325 2 + 0.554 0.539 -0.070
ENSG00000184922 E041 6.5516037 0.006326647 0.99744710 1.00000000 17 45245326 45245416 91 + 0.825 0.816 -0.034
ENSG00000184922 E042 5.9907082 0.003942909 0.48306622 0.62114697 17 45245632 45245733 102 + 0.710 0.802 0.371
ENSG00000184922 E043 5.7389985 0.003018315 0.31792541 0.46083701 17 45245878 45245973 96 + 0.664 0.802 0.563
ENSG00000184922 E044 0.1515154 0.046525719 0.19347803   17 45245974 45246209 236 + 0.181 0.000 -12.151
ENSG00000184922 E045 6.9193025 0.002586016 0.11453991 0.21217187 17 45246210 45246330 121 + 0.664 0.879 0.863
ENSG00000184922 E046 0.4418608 0.057225090 0.01366864 0.03746896 17 45246331 45246504 174 + 0.406 0.000 -13.730
ENSG00000184922 E047 0.6256415 0.017831064 0.05851499 0.12408899 17 45246505 45246604 100 + 0.406 0.081 -2.916
ENSG00000184922 E048 0.8772757 0.014931267 0.59707618 0.71890259 17 45246605 45246866 262 + 0.308 0.209 -0.744
ENSG00000184922 E049 11.5399741 0.002086164 0.08536657 0.16799742 17 45246867 45247319 453 + 0.887 1.075 0.697