ENSG00000184887

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392553 ENSG00000184887 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD6 protein_coding retained_intron 73.15801 120.335 46.77747 4.511696 0.9978688 -1.362982 46.164178 81.891675 22.335615 1.2252799 1.3250328 -1.8739012 0.62200833 0.68213333 0.47753333 -0.20460000 1.717829e-04 2.932538e-05 FALSE TRUE
ENST00000392554 ENSG00000184887 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD6 protein_coding protein_coding 73.15801 120.335 46.77747 4.511696 0.9978688 -1.362982 5.321540 6.801084 4.862428 1.7612887 0.6644027 -0.4832435 0.06892917 0.05560000 0.10463333 0.04903333 2.123047e-01 2.932538e-05 FALSE TRUE
ENST00000463376 ENSG00000184887 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD6 protein_coding protein_coding 73.15801 120.335 46.77747 4.511696 0.9978688 -1.362982 3.115826 3.182595 3.786231 0.4237251 0.5891221 0.2498382 0.04733333 0.02633333 0.08073333 0.05440000 2.932538e-05 2.932538e-05 FALSE TRUE
ENST00000536364 ENSG00000184887 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD6 protein_coding protein_coding 73.15801 120.335 46.77747 4.511696 0.9978688 -1.362982 18.556463 28.459617 15.793201 1.8860655 1.8684026 -0.8492063 0.26174167 0.23600000 0.33710000 0.10110000 9.948653e-02 2.932538e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184887 E001 0.2987644 0.0269971106 4.304781e-02   14 105248533 105248537 5 + 0.288 0.000 -13.440
ENSG00000184887 E002 2.0743993 0.0535000187 7.861547e-08 8.147409e-07 14 105248538 105248560 23 + 0.880 0.000 -16.249
ENSG00000184887 E003 14.6523400 0.0707163354 1.293333e-01 2.332439e-01 14 105248561 105248625 65 + 1.218 1.116 -0.364
ENSG00000184887 E004 50.6164592 0.0154268445 8.396276e-05 4.468367e-04 14 105248626 105248781 156 + 1.794 1.599 -0.659
ENSG00000184887 E005 156.9391189 0.0038059734 3.743231e-16 1.495453e-14 14 105248782 105249085 304 + 2.297 2.075 -0.744
ENSG00000184887 E006 18.1791355 0.0104407513 1.220539e-05 7.947324e-05 14 105249086 105249156 71 + 1.430 1.128 -1.059
ENSG00000184887 E007 144.1973386 0.0003274846 2.971720e-05 1.770388e-04 14 105249157 105249187 31 + 2.132 2.104 -0.095
ENSG00000184887 E008 232.6748596 0.0025041122 1.599801e-04 7.917385e-04 14 105249188 105249247 60 + 2.333 2.315 -0.062
ENSG00000184887 E009 36.9346686 0.0005980295 7.234794e-03 2.183389e-02 14 105249248 105249359 112 + 1.571 1.509 -0.210
ENSG00000184887 E010 490.6576121 0.0039690383 3.926735e-01 5.365986e-01 14 105249360 105249478 119 + 2.584 2.667 0.277
ENSG00000184887 E011 3918.0478911 0.0053082063 2.095771e-06 1.623079e-05 14 105249640 105251093 1454 + 3.430 3.587 0.520