ENSG00000184863

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287912 ENSG00000184863 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM33 protein_coding protein_coding 16.28547 12.97519 15.91923 0.4294143 0.3979603 0.2948099 1.071593 0.6012462 1.845466 0.04815557 0.3705155 1.601956 0.06767917 0.04623333 0.1150667 0.06883333 1.441065e-02 9.955771e-31 FALSE TRUE
ENST00000341148 ENSG00000184863 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM33 protein_coding protein_coding 16.28547 12.97519 15.91923 0.4294143 0.3979603 0.2948099 1.820183 3.3328921 0.000000 0.49691514 0.0000000 -8.384953 0.11808333 0.25520000 0.0000000 -0.25520000 1.634007e-26 9.955771e-31 FALSE FALSE
ENST00000392755 ENSG00000184863 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM33 protein_coding protein_coding 16.28547 12.97519 15.91923 0.4294143 0.3979603 0.2948099 1.260596 2.2877316 0.000000 1.22459613 0.0000000 -7.844066 0.08121667 0.17963333 0.0000000 -0.17963333 1.440013e-01 9.955771e-31 FALSE FALSE
ENST00000401878 ENSG00000184863 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM33 protein_coding protein_coding 16.28547 12.97519 15.91923 0.4294143 0.3979603 0.2948099 6.083858 3.3349327 7.320932 0.17346017 0.2826802 1.132020 0.36730833 0.25703333 0.4613667 0.20433333 3.877901e-05 9.955771e-31 FALSE TRUE
ENST00000440108 ENSG00000184863 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM33 protein_coding protein_coding 16.28547 12.97519 15.91923 0.4294143 0.3979603 0.2948099 1.385834 0.0000000 2.545399 0.00000000 0.1714370 7.997405 0.08030833 0.00000000 0.1595667 0.15956667 9.955771e-31 9.955771e-31 FALSE TRUE
MSTRG.30985.5 ENSG00000184863 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM33 protein_coding   16.28547 12.97519 15.91923 0.4294143 0.3979603 0.2948099 2.655790 2.0328213 2.746608 0.91125353 0.4519798 0.432331 0.15857083 0.15403333 0.1713333 0.01730000 8.441347e-01 9.955771e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184863 E001 6.0768627 0.0039371610 3.775521e-04 1.687693e-03 7 155644451 155644649 199 + 0.957 0.596 -1.453
ENSG00000184863 E002 4.2784007 0.0040737700 3.647952e-03 1.214917e-02 7 155644650 155644660 11 + 0.816 0.492 -1.397
ENSG00000184863 E003 5.2404712 0.0067226097 1.358498e-03 5.171469e-03 7 155644661 155644667 7 + 0.892 0.547 -1.428
ENSG00000184863 E004 10.6884821 0.0057507971 1.395176e-04 7.014160e-04 7 155644668 155644701 34 + 1.157 0.864 -1.079
ENSG00000184863 E005 58.4746597 0.0134302293 3.456319e-05 2.023953e-04 7 155644702 155644919 218 + 1.826 1.667 -0.536
ENSG00000184863 E006 59.7622044 0.0200207051 2.376385e-03 8.387656e-03 7 155665175 155665253 79 + 1.814 1.717 -0.328
ENSG00000184863 E007 40.8446884 0.0284491391 1.318492e-02 3.634021e-02 7 155672867 155672879 13 + 1.649 1.563 -0.293
ENSG00000184863 E008 54.7966032 0.0077219061 8.487210e-04 3.433286e-03 7 155672880 155672915 36 + 1.767 1.698 -0.232
ENSG00000184863 E009 81.5889907 0.0014987365 1.941837e-09 2.726214e-08 7 155678608 155678684 77 + 1.955 1.837 -0.396
ENSG00000184863 E010 96.5371410 0.0021400164 7.994983e-13 1.994766e-11 7 155680590 155680668 79 + 2.044 1.881 -0.548
ENSG00000184863 E011 183.5941468 0.0043120273 1.138395e-12 2.766007e-11 7 155680669 155680908 240 + 2.315 2.169 -0.488
ENSG00000184863 E012 5.3250120 0.0312578984 2.902501e-01 4.310340e-01 7 155684933 155685052 120 + 0.816 0.780 -0.143
ENSG00000184863 E013 118.0464708 0.0021620038 4.090348e-15 1.425242e-13 7 155700773 155700890 118 + 2.132 1.962 -0.571
ENSG00000184863 E014 76.0730080 0.0015030652 3.844812e-10 6.151407e-09 7 155700891 155700944 54 + 1.932 1.793 -0.468
ENSG00000184863 E015 10.9628995 0.0016370117 8.144378e-01 8.824295e-01 7 155700945 155701490 546 + 1.024 1.134 0.397
ENSG00000184863 E016 0.1451727 0.0431959120 5.740396e-01   7 155706814 155706859 46 + 0.098 0.000 -24.223
ENSG00000184863 E017 98.1982270 0.0110447472 2.135498e-03 7.644239e-03 7 155706860 155707068 209 + 2.004 1.962 -0.141
ENSG00000184863 E018 0.1515154 0.0428297471 5.739596e-01   7 155707294 155707380 87 + 0.098 0.000 -24.224
ENSG00000184863 E019 10.6432443 0.0051192755 7.870967e-01 8.636685e-01 7 155711173 155711202 30 + 1.003 1.107 0.380
ENSG00000184863 E020 77.2868355 0.0258600852 3.150228e-02 7.488479e-02 7 155711203 155711455 253 + 1.898 1.867 -0.103
ENSG00000184863 E021 50.4021955 0.0109848478 7.083155e-04 2.928915e-03 7 155718385 155718443 59 + 1.739 1.643 -0.327
ENSG00000184863 E022 70.0982472 0.0003778328 2.411888e-09 3.330357e-08 7 155737530 155737662 133 + 1.887 1.771 -0.391
ENSG00000184863 E023 99.5362272 0.0002907171 1.272798e-08 1.538688e-07 7 155738060 155738403 344 + 2.020 1.959 -0.206
ENSG00000184863 E024 1.1060086 0.0143259112 5.476798e-01 6.776857e-01 7 155738404 155739714 1311 + 0.244 0.428 1.152
ENSG00000184863 E025 53.3788697 0.0005733176 2.846674e-03 9.814087e-03 7 155739715 155740026 312 + 1.732 1.729 -0.010
ENSG00000184863 E026 99.4568600 0.0016917772 9.969430e-02 1.900156e-01 7 155741819 155742106 288 + 1.961 2.040 0.263
ENSG00000184863 E027 235.5752963 0.0015832706 9.197724e-01 9.533113e-01 7 155744961 155745602 642 + 2.298 2.447 0.496
ENSG00000184863 E028 1.1081736 0.0123109968 3.638181e-01 5.082506e-01 7 155745603 155745720 118 + 0.354 0.265 -0.583
ENSG00000184863 E029 0.2924217 0.0290785164 2.532333e-01   7 155746419 155746585 167 + 0.177 0.000 -25.223
ENSG00000184863 E030 0.1472490 0.0429080492 5.740381e-01   7 155746586 155746665 80 + 0.098 0.000 -24.223
ENSG00000184863 E031 14.5829558 0.0364888113 4.950271e-01 6.319076e-01 7 155763809 155763811 3 + 1.064 1.299 0.837
ENSG00000184863 E032 110.8533902 0.0022057427 6.241738e-01 7.405904e-01 7 155763812 155764018 207 + 1.963 2.128 0.552
ENSG00000184863 E033 79.9474414 0.0009045318 1.684410e-01 2.861478e-01 7 155766467 155766555 89 + 1.861 1.947 0.291
ENSG00000184863 E034 78.0813214 0.0068338230 1.666876e-01 2.838820e-01 7 155766556 155766655 100 + 1.862 1.927 0.219
ENSG00000184863 E035 8.3851247 0.0049659740 3.051603e-03 1.041784e-02 7 155766656 155766896 241 + 0.702 1.173 1.784
ENSG00000184863 E036 80.8508318 0.0080949085 1.387514e-02 3.794393e-02 7 155774559 155774647 89 + 1.908 1.905 -0.009
ENSG00000184863 E037 84.1787206 0.0017190156 2.959358e-02 7.116005e-02 7 155774993 155775097 105 + 1.901 1.951 0.169
ENSG00000184863 E038 1994.7904252 0.0101246823 2.405597e-11 4.711522e-10 7 155775098 155781485 6388 + 3.129 3.452 1.073