ENSG00000184828

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000535628 ENSG00000184828 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB7C protein_coding protein_coding 0.8438313 1.434621 0.8117796 0.1471424 0.1962319 -0.8138673 0.35500538 0.9753102 0.2938826 0.11737084 0.1139148 -1.6970640 0.43895417 0.67863333 0.3489667 -0.32966667 0.02920652 0.02920652 FALSE TRUE
ENST00000586438 ENSG00000184828 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB7C protein_coding protein_coding 0.8438313 1.434621 0.8117796 0.1471424 0.1962319 -0.8138673 0.03215228 0.0000000 0.0000000 0.00000000 0.0000000 0.0000000 0.05805000 0.00000000 0.0000000 0.00000000   0.02920652 FALSE TRUE
ENST00000588149 ENSG00000184828 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB7C protein_coding protein_coding 0.8438313 1.434621 0.8117796 0.1471424 0.1962319 -0.8138673 0.04356697 0.1030851 0.0000000 0.05311228 0.0000000 -3.4993374 0.03326667 0.06753333 0.0000000 -0.06753333 0.19354398 0.02920652   FALSE
ENST00000590178 ENSG00000184828 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB7C protein_coding protein_coding 0.8438313 1.434621 0.8117796 0.1471424 0.1962319 -0.8138673 0.02293917 0.0000000 0.1835134 0.00000000 0.1835134 4.2743616 0.01931667 0.00000000 0.1545333 0.15453333 0.68161568 0.02920652   FALSE
ENST00000590800 ENSG00000184828 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB7C protein_coding protein_coding 0.8438313 1.434621 0.8117796 0.1471424 0.1962319 -0.8138673 0.31039680 0.2732085 0.2262702 0.13822305 0.1138621 -0.2614272 0.36600417 0.19863333 0.3680333 0.16940000 0.86659922 0.02920652 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184828 E001 0.1482932 0.041916143 1.000000000   18 48026672 48026672 1 - 0.000 0.086 7.639
ENSG00000184828 E002 92.4761131 0.013841918 0.011271843 0.03181207 18 48026673 48029911 3239 - 1.829 1.950 0.406
ENSG00000184828 E003 29.3709829 0.001195640 0.555519890 0.68436452 18 48039900 48040907 1008 - 1.434 1.431 -0.011
ENSG00000184828 E004 5.8455789 0.003119292 0.318023926 0.46094455 18 48040908 48041032 125 - 0.864 0.764 -0.392
ENSG00000184828 E005 2.9076005 0.005576645 0.711330675 0.80831751 18 48041033 48041051 19 - 0.592 0.558 -0.153
ENSG00000184828 E006 1.9488540 0.013763755 0.758405765 0.84301571 18 48041052 48041062 11 - 0.468 0.438 -0.154
ENSG00000184828 E007 4.0720996 0.009137228 0.396553933 0.54030790 18 48041063 48041123 61 - 0.730 0.631 -0.412
ENSG00000184828 E008 0.0000000       18 48072460 48072610 151 -      
ENSG00000184828 E009 0.0000000       18 48076936 48077003 68 -      
ENSG00000184828 E010 0.0000000       18 48087670 48087798 129 -      
ENSG00000184828 E011 0.0000000       18 48088256 48088355 100 -      
ENSG00000184828 E012 2.5284966 0.052540139 0.552128104 0.68145562 18 48137007 48137361 355 - 0.390 0.535 0.739
ENSG00000184828 E013 0.0000000       18 48162348 48162397 50 -      
ENSG00000184828 E014 0.0000000       18 48165127 48165130 4 -      
ENSG00000184828 E015 0.8803856 0.016582719 0.006700028 0.02044587 18 48165131 48165253 123 - 0.535 0.086 -3.474
ENSG00000184828 E016 0.7352129 0.019731358 0.020821162 0.05321426 18 48165254 48165257 4 - 0.468 0.086 -3.153
ENSG00000184828 E017 0.0000000       18 48165258 48165566 309 -      
ENSG00000184828 E018 0.0000000       18 48180330 48180386 57 -      
ENSG00000184828 E019 0.1482932 0.041916143 1.000000000   18 48180387 48180477 91 - 0.000 0.086 9.367
ENSG00000184828 E020 0.7738329 0.047565221 0.654675526 0.76478726 18 48185324 48185455 132 - 0.172 0.271 0.838
ENSG00000184828 E021 2.4992421 0.006383733 0.025840804 0.06361048 18 48185934 48185995 62 - 0.730 0.403 -1.515
ENSG00000184828 E022 0.0000000       18 48203415 48203601 187 -      
ENSG00000184828 E023 0.0000000       18 48252161 48252298 138 -      
ENSG00000184828 E024 2.5348157 0.006163696 0.161106625 0.27656255 18 48338174 48338398 225 - 0.643 0.439 -0.957
ENSG00000184828 E025 0.0000000       18 48346553 48346698 146 -      
ENSG00000184828 E026 0.0000000       18 48350545 48350588 44 -      
ENSG00000184828 E027 0.0000000       18 48364154 48364214 61 -      
ENSG00000184828 E028 0.0000000       18 48374222 48374313 92 -      
ENSG00000184828 E029 0.0000000       18 48375538 48375625 88 -      
ENSG00000184828 E030 0.1817044 0.038771739 1.000000000   18 48408358 48408655 298 - 0.000 0.086 9.376
ENSG00000184828 E031 1.0383430 0.047025642 0.072125591 0.14687237 18 48409226 48409383 158 - 0.468 0.158 -2.142
ENSG00000184828 E032 0.0000000       18 48410679 48410752 74 -