ENSG00000184787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345496 ENSG00000184787 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2G2 protein_coding protein_coding 102.6068 81.3084 123.0046 6.82336 2.143616 0.5971763 6.503895 8.819622 6.219404 0.8482233 0.741881 -0.5032575 0.06776250 0.11033333 0.05076667 -0.05956667 8.665615e-03 1.721624e-06 FALSE TRUE
ENST00000462569 ENSG00000184787 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2G2 protein_coding retained_intron 102.6068 81.3084 123.0046 6.82336 2.143616 0.5971763 16.858322 5.360614 27.564034 0.8595860 1.636410 2.3601514 0.15334583 0.06870000 0.22380000 0.15510000 1.179972e-04 1.721624e-06   FALSE
ENST00000481546 ENSG00000184787 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2G2 protein_coding retained_intron 102.6068 81.3084 123.0046 6.82336 2.143616 0.5971763 10.644475 3.079314 17.369805 0.3771048 1.137522 2.4920534 0.09912500 0.03926667 0.14096667 0.10170000 1.721624e-06 1.721624e-06 FALSE TRUE
ENST00000497630 ENSG00000184787 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2G2 protein_coding processed_transcript 102.6068 81.3084 123.0046 6.82336 2.143616 0.5971763 9.729460 2.566012 16.511464 0.6493950 1.000178 2.6811305 0.08552917 0.03243333 0.13406667 0.10163333 2.575917e-04 1.721624e-06 FALSE TRUE
ENST00000497664 ENSG00000184787 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2G2 protein_coding processed_transcript 102.6068 81.3084 123.0046 6.82336 2.143616 0.5971763 5.256722 4.372103 7.422152 0.7302173 1.217810 0.7621567 0.05122083 0.05306667 0.06026667 0.00720000 8.539475e-01 1.721624e-06 FALSE FALSE
MSTRG.21466.2 ENSG00000184787 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2G2 protein_coding   102.6068 81.3084 123.0046 6.82336 2.143616 0.5971763 48.489638 53.800130 40.991893 7.5948283 2.259533 -0.3921873 0.49440833 0.65520000 0.33400000 -0.32120000 3.300959e-06 1.721624e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184787 E001 6.6760772 0.0068093199 3.898360e-03 1.285858e-02 21 44768580 44769039 460 - 0.640 1.063 1.648
ENSG00000184787 E002 3533.9676911 0.0050668092 5.714756e-15 1.949304e-13 21 44769040 44770930 1891 - 3.417 3.659 0.802
ENSG00000184787 E003 247.4980130 0.0018669052 2.236477e-02 5.643833e-02 21 44770931 44770971 41 - 2.331 2.461 0.434
ENSG00000184787 E004 924.1002790 0.0006286996 6.985991e-01 7.985296e-01 21 44770972 44771278 307 - 2.935 3.002 0.222
ENSG00000184787 E005 387.3602324 0.0001591148 2.378679e-02 5.937669e-02 21 44771279 44771294 16 - 2.582 2.605 0.076
ENSG00000184787 E006 792.5190928 0.0003478523 5.272411e-03 1.667322e-02 21 44771295 44771489 195 - 2.892 2.914 0.073
ENSG00000184787 E007 278.4798537 0.0002064493 4.968094e-01 6.334017e-01 21 44773547 44773547 1 - 2.426 2.476 0.166
ENSG00000184787 E008 594.6509885 0.0002380983 8.287273e-02 1.640474e-01 21 44773548 44773687 140 - 2.761 2.798 0.122
ENSG00000184787 E009 201.3634688 0.0236915845 7.790147e-10 1.179147e-08 21 44773688 44774530 843 - 2.462 2.015 -1.493
ENSG00000184787 E010 44.5503396 0.0005257933 3.421836e-23 3.101706e-21 21 44774531 44774566 36 - 1.829 1.314 -1.761
ENSG00000184787 E011 84.9402941 0.0011922156 1.741975e-50 1.092755e-47 21 44774567 44774720 154 - 2.132 1.483 -2.191
ENSG00000184787 E012 47.7965614 0.0029900379 1.110667e-31 2.085358e-29 21 44774721 44774741 21 - 1.896 1.175 -2.475
ENSG00000184787 E013 67.7466856 0.0145352942 1.389940e-20 9.519882e-19 21 44774742 44774820 79 - 2.042 1.341 -2.385
ENSG00000184787 E014 217.2630270 0.0239396265 9.485095e-19 5.257235e-17 21 44774821 44775436 616 - 2.542 1.857 -2.292
ENSG00000184787 E015 124.3326232 0.0291509820 3.497957e-14 1.061983e-12 21 44776834 44777253 420 - 2.297 1.634 -2.230
ENSG00000184787 E016 41.6199930 0.0470405631 1.602522e-09 2.286953e-08 21 44777254 44777298 45 - 1.837 1.113 -2.497
ENSG00000184787 E017 502.3875078 0.0001234422 3.037766e-02 7.270674e-02 21 44777299 44777376 78 - 2.691 2.721 0.099
ENSG00000184787 E018 414.2475949 0.0013893364 4.342896e-02 9.734712e-02 21 44777377 44777417 41 - 2.615 2.626 0.037
ENSG00000184787 E019 3.5322850 0.0427692503 5.962124e-01 7.181821e-01 21 44779144 44779216 73 - 0.581 0.714 0.574
ENSG00000184787 E020 0.7061804 0.1550090204 8.495315e-01 9.066344e-01 21 44785666 44785791 126 - 0.194 0.247 0.442
ENSG00000184787 E021 385.4714264 0.0006654397 7.066723e-06 4.861711e-05 21 44787920 44787965 46 - 2.605 2.570 -0.116
ENSG00000184787 E022 333.9402811 0.0004033419 1.143709e-04 5.879365e-04 21 44788060 44788095 36 - 2.535 2.516 -0.063
ENSG00000184787 E023 7.5440096 0.0022653175 9.499641e-01 9.726903e-01 21 44799391 44799480 90 - 0.904 0.969 0.243
ENSG00000184787 E024 36.0571373 0.0070754459 3.450646e-01 4.891499e-01 21 44799990 44801283 1294 - 1.503 1.629 0.428
ENSG00000184787 E025 20.9311629 0.0009214661 5.198933e-01 6.539467e-01 21 44801284 44801398 115 - 1.338 1.352 0.050
ENSG00000184787 E026 303.1631708 0.0044060048 6.108274e-03 1.889389e-02 21 44801706 44801826 121 - 2.505 2.456 -0.164