ENSG00000184752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327772 ENSG00000184752 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFA12 protein_coding protein_coding 164.3679 214.5098 156.1407 17.31154 2.441086 -0.4581714 147.4798 185.6147 143.2404 14.44277 1.730592 -0.3738499 0.8982 0.8658 0.9175 0.0517 0.008748429 0.008748429 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184752 E001 1.9154428 0.0171298064 7.340861e-01 8.251424e-01 12 94895297 94897091 1795 - 0.424 0.484 0.308
ENSG00000184752 E002 1.5091596 0.0194630511 4.564468e-01 5.968587e-01 12 94897092 94897310 219 - 0.486 0.357 -0.693
ENSG00000184752 E003 0.4449813 0.0212238681 3.278303e-01 4.713034e-01 12 94910233 94910343 111 - 0.262 0.099 -1.689
ENSG00000184752 E004 1.4854152 0.0125636998 8.054859e-03 2.391876e-02 12 94924646 94924806 161 - 0.634 0.180 -2.690
ENSG00000184752 E005 2.1507089 0.0101872331 5.457671e-02 1.172493e-01 12 94928017 94928263 247 - 0.674 0.358 -1.538
ENSG00000184752 E006 7.2425794 0.0044603762 3.567289e-06 2.626145e-05 12 94971328 94971331 4 - 0.350 1.050 3.046
ENSG00000184752 E007 8.0540768 0.0057690658 4.728673e-06 3.385612e-05 12 94971332 94971332 1 - 0.424 1.088 2.766
ENSG00000184752 E008 8.7872240 0.0034515554 7.014246e-07 6.021515e-06 12 94971333 94971335 3 - 0.424 1.123 2.894
ENSG00000184752 E009 812.5630387 0.0002171206 1.307485e-01 2.351961e-01 12 94971336 94971477 142 - 2.879 2.898 0.065
ENSG00000184752 E010 639.3025432 0.0001835369 2.593523e-04 1.214103e-03 12 94971478 94971485 8 - 2.751 2.805 0.181
ENSG00000184752 E011 791.1910808 0.0005131715 7.184016e-01 8.135079e-01 12 94971486 94971515 30 - 2.876 2.880 0.012
ENSG00000184752 E012 1221.7683687 0.0002216010 6.154350e-02 1.292340e-01 12 94971516 94971620 105 - 3.055 3.075 0.066
ENSG00000184752 E013 3.8329332 0.0042335879 3.166703e-02 7.519991e-02 12 94971621 94972394 774 - 0.424 0.768 1.559
ENSG00000184752 E014 0.4438354 0.0519998864 8.884567e-01 9.326765e-01 12 94972395 94972489 95 - 0.150 0.179 0.304
ENSG00000184752 E015 4.0085114 0.0058680177 6.153969e-01 7.336826e-01 12 94974171 94974285 115 - 0.634 0.708 0.312
ENSG00000184752 E016 2.3657968 0.0070177151 3.859527e-01 5.301641e-01 12 94991827 94991972 146 - 0.590 0.447 -0.686
ENSG00000184752 E017 1051.5462510 0.0001188818 6.735116e-01 7.791761e-01 12 94994170 94994257 88 - 3.006 3.000 -0.019
ENSG00000184752 E018 7.1671588 0.0024864494 3.425071e-01 4.865064e-01 12 94994258 94995678 1421 - 0.967 0.854 -0.425
ENSG00000184752 E019 3.4028936 0.0196449484 4.003540e-01 5.440489e-01 12 94996904 94996976 73 - 0.710 0.581 -0.553
ENSG00000184752 E020 6.1722786 0.0032514998 1.894481e-08 2.218879e-07 12 94997308 94997410 103 - 1.165 0.446 -2.924
ENSG00000184752 E021 1.9929248 0.0142291777 5.472959e-02 1.175244e-01 12 94997411 94998733 1323 - 0.634 0.307 -1.684
ENSG00000184752 E022 0.9286724 0.0149636191 2.561155e-02 6.314625e-02 12 94998734 94999755 1022 - 0.486 0.099 -3.010
ENSG00000184752 E023 989.7873071 0.0003514511 3.421535e-01 4.861503e-01 12 95002739 95002805 67 - 2.985 2.970 -0.052
ENSG00000184752 E024 624.9097514 0.0011111839 2.824940e-02 6.850346e-02 12 95002806 95002821 16 - 2.806 2.756 -0.167
ENSG00000184752 E025 705.6809609 0.0003518653 6.785569e-04 2.820576e-03 12 95003595 95003748 154 - 2.863 2.809 -0.182