ENSG00000184743

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398868 ENSG00000184743 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL3 protein_coding protein_coding 13.39427 15.16157 12.53262 2.266542 0.1862764 -0.2745314 4.705605 3.1073312 6.060598 0.6318718 0.15925615 0.961527126 0.35930417 0.21036667 0.48343333 0.27306667 0.0002136439 0.0002136439 FALSE TRUE
ENST00000535789 ENSG00000184743 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL3 protein_coding processed_transcript 13.39427 15.16157 12.53262 2.266542 0.1862764 -0.2745314 0.924377 0.9561846 0.960000 0.2052661 0.09678921 0.005685775 0.07019167 0.06386667 0.07683333 0.01296667 0.7563471823 0.0002136439   FALSE
ENST00000538786 ENSG00000184743 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL3 protein_coding protein_coding 13.39427 15.16157 12.53262 2.266542 0.1862764 -0.2745314 3.604693 5.3650505 2.974706 0.6909139 0.04255307 -0.848689554 0.25931667 0.35670000 0.23736667 -0.11933333 0.0002735877 0.0002136439 FALSE TRUE
MSTRG.5634.3 ENSG00000184743 HEK293_OSMI2_2hA HEK293_TMG_2hB ATL3 protein_coding   13.39427 15.16157 12.53262 2.266542 0.1862764 -0.2745314 4.159591 5.7330020 2.537317 1.2719376 0.10626278 -1.172826676 0.31117917 0.36900000 0.20236667 -0.16663333 0.0013488119 0.0002136439 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184743 E001 547.9548755 0.0203760563 3.785450e-07 3.429169e-06 11 63624087 63629140 5054 - 2.916 2.552 -1.210
ENSG00000184743 E002 80.5937124 0.0004080919 5.907236e-02 1.250344e-01 11 63629141 63629252 112 - 1.909 1.907 -0.009
ENSG00000184743 E003 150.7872759 0.0003153878 2.981215e-07 2.760961e-06 11 63629253 63629405 153 - 2.130 2.202 0.241
ENSG00000184743 E004 287.4789428 0.0001933054 1.077170e-15 4.048941e-14 11 63631040 63631471 432 - 2.400 2.488 0.292
ENSG00000184743 E005 90.7461233 0.0134543720 7.812687e-02 1.564627e-01 11 63633026 63633097 72 - 1.929 1.968 0.130
ENSG00000184743 E006 71.5890445 0.0099268957 1.162592e-01 2.146267e-01 11 63635534 63635590 57 - 1.841 1.857 0.055
ENSG00000184743 E007 118.4493861 0.0043041700 1.442548e-01 2.537996e-01 11 63636207 63636334 128 - 2.080 2.061 -0.063
ENSG00000184743 E008 116.0385159 0.0086291486 3.215293e-01 4.647854e-01 11 63643357 63643495 139 - 2.076 2.050 -0.084
ENSG00000184743 E009 85.8193592 0.0035964766 1.735188e-04 8.505645e-04 11 63644169 63644261 93 - 1.869 1.966 0.326
ENSG00000184743 E010 74.3341913 0.0071122346 1.544649e-03 5.780216e-03 11 63646507 63646563 57 - 1.806 1.902 0.322
ENSG00000184743 E011 67.2098151 0.0004235069 1.286690e-03 4.932707e-03 11 63651936 63651986 51 - 1.788 1.851 0.212
ENSG00000184743 E012 107.6345647 0.0002726421 2.672905e-02 6.542897e-02 11 63652471 63652575 105 - 2.032 2.030 -0.008
ENSG00000184743 E013 78.0957984 0.0003387593 9.060658e-02 1.760835e-01 11 63658761 63658813 53 - 1.901 1.891 -0.032
ENSG00000184743 E014 106.6721383 0.0003705707 9.440000e-01 9.689071e-01 11 63658814 63658904 91 - 2.072 1.997 -0.251
ENSG00000184743 E015 131.9023879 0.0005315444 4.232813e-01 5.663651e-01 11 63659038 63659252 215 - 2.178 2.075 -0.346
ENSG00000184743 E016 0.4720498 0.1539484676 5.524751e-01 6.817618e-01 11 63670357 63670512 156 - 0.245 0.107 -1.437
ENSG00000184743 E017 59.4601906 0.0007013020 9.790927e-01 9.909773e-01 11 63671290 63671411 122 - 1.822 1.743 -0.266
ENSG00000184743 E018 29.2046601 0.0067900531 8.068838e-01 8.773298e-01 11 63671412 63671635 224 - 1.507 1.443 -0.219
ENSG00000184743 E019 5.9138812 0.0030326829 8.066791e-03 2.394968e-02 11 63671636 63671957 322 - 1.036 0.638 -1.562