ENSG00000184677

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374651 ENSG00000184677 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB40 protein_coding protein_coding 9.724651 8.144519 7.465253 0.6079259 0.1910619 -0.1254773 0.8174320 2.7063050 0.1321241 0.5067539 0.07437997 -4.2564228 0.09069167 0.3435667 0.0179000 -0.3256667 0.0003909401 0.0003909401 FALSE TRUE
ENST00000375647 ENSG00000184677 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB40 protein_coding protein_coding 9.724651 8.144519 7.465253 0.6079259 0.1910619 -0.1254773 7.4748195 4.3339987 5.7353908 0.8382593 0.30254717 0.4033814 0.75975417 0.5236333 0.7672333 0.2436000 0.0103189016 0.0003909401 FALSE TRUE
MSTRG.506.3 ENSG00000184677 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB40 protein_coding   9.724651 8.144519 7.465253 0.6079259 0.1910619 -0.1254773 0.6405754 0.8751706 0.8269613 0.1295496 0.21430971 -0.0807946 0.06872083 0.1064000 0.1118000 0.0054000 1.0000000000 0.0003909401 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184677 E001 0.1515154 0.0432528591 4.300009e-01   1 22428838 22428851 14 + 0.120 0.000 -8.830
ENSG00000184677 E002 0.1515154 0.0432528591 4.300009e-01   1 22428852 22428859 8 + 0.120 0.000 -11.124
ENSG00000184677 E003 0.1515154 0.0432528591 4.300009e-01   1 22428860 22428861 2 + 0.120 0.000 -11.124
ENSG00000184677 E004 0.6621732 0.0475542340 8.866953e-01 9.315310e-01 1 22428862 22428870 9 + 0.214 0.222 0.067
ENSG00000184677 E005 1.9468543 0.0079570061 1.659157e-01 2.828801e-01 1 22428871 22428886 16 + 0.550 0.368 -0.933
ENSG00000184677 E006 10.6265746 0.0038645612 7.097344e-03 2.148185e-02 1 22428887 22429014 128 + 1.157 0.954 -0.741
ENSG00000184677 E007 0.0000000       1 22451851 22451861 11 +      
ENSG00000184677 E008 2.6057697 0.1145670570 5.521475e-03 1.734245e-02 1 22451862 22451866 5 + 0.760 0.223 -2.824
ENSG00000184677 E009 14.2737998 0.0090823796 1.108863e-06 9.116863e-06 1 22451867 22452004 138 + 1.355 0.938 -1.496
ENSG00000184677 E010 1.9209318 0.0078344523 4.756540e-02 1.048476e-01 1 22452659 22452946 288 + 0.587 0.301 -1.518
ENSG00000184677 E011 104.9092283 0.0203078169 8.950425e-07 7.508108e-06 1 22489880 22490645 766 + 2.150 1.873 -0.931
ENSG00000184677 E012 36.6527441 0.0130414094 1.273211e-05 8.256802e-05 1 22491400 22491533 134 + 1.699 1.439 -0.889
ENSG00000184677 E013 32.9295343 0.0007243217 2.629055e-06 1.993383e-05 1 22501492 22501554 63 + 1.630 1.425 -0.702
ENSG00000184677 E014 47.0748429 0.0005135838 4.545191e-05 2.587047e-04 1 22501555 22501684 130 + 1.741 1.612 -0.436
ENSG00000184677 E015 29.9069435 0.0006958797 1.216139e-04 6.212087e-04 1 22502299 22502340 42 + 1.568 1.403 -0.565
ENSG00000184677 E016 41.3273498 0.0006839758 3.410220e-07 3.119687e-06 1 22502341 22502441 101 + 1.718 1.518 -0.680
ENSG00000184677 E017 60.8659905 0.0038317321 8.056802e-10 1.216011e-08 1 22506049 22506241 193 + 1.902 1.654 -0.838
ENSG00000184677 E018 48.7547561 0.0193352339 8.990538e-04 3.610758e-03 1 22508001 22508137 137 + 1.786 1.599 -0.634
ENSG00000184677 E019 59.4280207 0.0140781378 3.310589e-03 1.117830e-02 1 22508530 22508731 202 + 1.845 1.718 -0.429
ENSG00000184677 E020 60.6865998 0.0151319370 1.150606e-02 3.236462e-02 1 22509100 22509233 134 + 1.843 1.741 -0.345
ENSG00000184677 E021 61.9048413 0.0087218892 1.288991e-02 3.565836e-02 1 22511179 22511347 169 + 1.837 1.764 -0.245
ENSG00000184677 E022 103.3260569 0.0003336990 3.326612e-05 1.956162e-04 1 22511676 22512134 459 + 2.051 1.988 -0.211
ENSG00000184677 E023 65.2924657 0.0003842015 2.536149e-03 8.871556e-03 1 22512924 22513130 207 + 1.845 1.794 -0.172
ENSG00000184677 E024 59.5534770 0.0021967455 6.496280e-02 1.349731e-01 1 22517300 22517464 165 + 1.786 1.773 -0.044
ENSG00000184677 E025 65.1564311 0.0004204360 6.668809e-01 7.742616e-01 1 22520061 22520275 215 + 1.761 1.859 0.332
ENSG00000184677 E026 64.3955242 0.0004806174 7.663992e-01 8.489201e-01 1 22521496 22521658 163 + 1.758 1.851 0.313
ENSG00000184677 E027 41.8594518 0.0005099747 8.577351e-01 9.121368e-01 1 22522377 22522463 87 + 1.593 1.662 0.235
ENSG00000184677 E028 80.5150903 0.0003651774 5.233983e-01 6.571077e-01 1 22524218 22524444 227 + 1.879 1.934 0.184
ENSG00000184677 E029 98.6676153 0.0017748653 3.564953e-01 5.008712e-01 1 22526202 22526490 289 + 1.970 2.012 0.143
ENSG00000184677 E030 254.8758959 0.0025414973 5.754974e-02 1.224175e-01 1 22526491 22527585 1095 + 2.326 2.465 0.464
ENSG00000184677 E031 944.4894538 0.0055260833 2.397590e-18 1.259962e-16 1 22527586 22531157 3572 + 2.787 3.089 1.007
ENSG00000184677 E032 0.1472490 0.0427987147 4.307063e-01   1 22552059 22552109 51 + 0.120 0.000 -11.129