ENSG00000184640

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423034 ENSG00000184640 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN9 protein_coding protein_coding 38.34044 68.735 26.8353 3.061374 0.7999546 -1.356585 7.775611 8.3472335 9.516614 1.10786794 0.1157808 0.1889381 0.21951250 0.120500000 0.35540000 0.23490000 2.779755e-14 2.337958e-21 FALSE TRUE
ENST00000427177 ENSG00000184640 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN9 protein_coding protein_coding 38.34044 68.735 26.8353 3.061374 0.7999546 -1.356585 12.875842 21.5634813 9.362113 3.60265538 1.6806619 -1.2028128 0.34334583 0.311866667 0.35266667 0.04080000 8.859074e-01 2.337958e-21 FALSE TRUE
ENST00000541152 ENSG00000184640 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN9 protein_coding protein_coding 38.34044 68.735 26.8353 3.061374 0.7999546 -1.356585 6.416321 20.7757544 0.000000 3.56834840 0.0000000 -11.0213794 0.12494167 0.305233333 0.00000000 -0.30523333 2.337958e-21 2.337958e-21 FALSE TRUE
ENST00000589250 ENSG00000184640 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN9 protein_coding retained_intron 38.34044 68.735 26.8353 3.061374 0.7999546 -1.356585 1.036686 0.3143155 2.157541 0.05077972 1.1169466 2.7405890 0.03772917 0.004533333 0.07803333 0.07350000 4.537819e-01 2.337958e-21 FALSE TRUE
ENST00000591198 ENSG00000184640 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN9 protein_coding protein_coding 38.34044 68.735 26.8353 3.061374 0.7999546 -1.356585 6.612724 13.5597786 4.332344 1.14398343 1.6168156 -1.6438512 0.16179167 0.196733333 0.15860000 -0.03813333 7.297950e-01 2.337958e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184640 E001 0.0000000       17 77280569 77280806 238 +      
ENSG00000184640 E002 1.0748747 0.0342380693 2.789668e-01 4.186557e-01 17 77281437 77281450 14 + 0.390 0.220 -1.138
ENSG00000184640 E003 17.2384783 0.0033407323 5.497870e-01 6.794892e-01 17 77281451 77281498 48 + 1.117 1.231 0.404
ENSG00000184640 E004 37.1184744 0.0005937647 4.805005e-02 1.057178e-01 17 77281499 77281554 56 + 1.572 1.506 -0.223
ENSG00000184640 E005 0.0000000       17 77286307 77286441 135 +      
ENSG00000184640 E006 0.2214452 0.0384268356 1.000000e+00   17 77287891 77287948 58 + 0.000 0.086 28.625
ENSG00000184640 E007 0.9201370 0.0132738497 6.763086e-01 7.813144e-01 17 77287949 77288210 262 + 0.171 0.273 0.857
ENSG00000184640 E008 0.0000000       17 77288211 77288214 4 +      
ENSG00000184640 E009 0.3289534 0.0294005272 4.976247e-01   17 77294489 77294571 83 + 0.171 0.086 -1.145
ENSG00000184640 E010 0.5503986 0.0202691083 8.434159e-01 9.024972e-01 17 77294774 77294903 130 + 0.171 0.158 -0.143
ENSG00000184640 E011 36.2488157 0.0038767717 7.628893e-03 2.284544e-02 17 77307141 77307197 57 + 1.604 1.483 -0.416
ENSG00000184640 E012 2.8616015 0.0053336016 1.324159e-01 2.374421e-01 17 77319518 77319591 74 + 0.294 0.609 1.663
ENSG00000184640 E013 2.2747585 0.0442394516 3.725148e-01 5.169603e-01 17 77319592 77319601 10 + 0.294 0.508 1.197
ENSG00000184640 E014 8.5993644 0.0020303322 5.128795e-04 2.208060e-03 17 77319602 77319803 202 + 0.468 1.035 2.347
ENSG00000184640 E015 13.8204451 0.0012786972 2.649811e-03 9.222154e-03 17 77319804 77320223 420 + 0.801 1.201 1.483
ENSG00000184640 E016 6.7676853 0.0023946273 8.128410e-03 2.410958e-02 17 77320224 77320312 89 + 0.468 0.926 1.943
ENSG00000184640 E017 8.7510662 0.0019522685 1.195657e-04 6.118848e-04 17 77320313 77320348 36 + 0.390 1.036 2.763
ENSG00000184640 E018 0.0000000       17 77322610 77322670 61 +      
ENSG00000184640 E019 0.0000000       17 77322789 77322948 160 +      
ENSG00000184640 E020 0.0000000       17 77323706 77323811 106 +      
ENSG00000184640 E021 5.4876827 0.0893380865 1.570421e-01 2.711651e-01 17 77373190 77373336 147 + 0.891 0.701 -0.754
ENSG00000184640 E022 79.2555353 0.0004787860 1.779118e-25 2.042718e-23 17 77373337 77373552 216 + 2.081 1.713 -1.240
ENSG00000184640 E023 0.1817044 0.0397332841 1.000000e+00   17 77373933 77374137 205 + 0.000 0.086 28.622
ENSG00000184640 E024 0.1817044 0.0397332841 1.000000e+00   17 77374177 77374357 181 + 0.000 0.086 28.622
ENSG00000184640 E025 0.0000000       17 77375921 77376082 162 +      
ENSG00000184640 E026 0.0000000       17 77376083 77376398 316 +      
ENSG00000184640 E027 0.0000000       17 77380123 77380249 127 +      
ENSG00000184640 E028 0.0000000       17 77400558 77400583 26 +      
ENSG00000184640 E029 0.2214452 0.0384268356 1.000000e+00   17 77400584 77400590 7 + 0.000 0.086 28.625
ENSG00000184640 E030 0.1817044 0.0397332841 1.000000e+00   17 77400591 77400718 128 + 0.000 0.086 28.622
ENSG00000184640 E031 152.9070541 0.0002221723 1.002544e-08 1.235792e-07 17 77402059 77402100 42 + 2.215 2.097 -0.394
ENSG00000184640 E032 392.8040261 0.0039878912 3.002888e-03 1.027337e-02 17 77402101 77402336 236 + 2.572 2.531 -0.135
ENSG00000184640 E033 234.5700026 0.0022447227 4.466600e-01 5.881384e-01 17 77402337 77402402 66 + 2.291 2.327 0.120
ENSG00000184640 E034 285.2826317 0.0013421290 1.487743e-01 2.600221e-01 17 77402403 77402495 93 + 2.389 2.408 0.065
ENSG00000184640 E035 242.7299429 0.0025369808 3.072283e-02 7.337251e-02 17 77402496 77402555 60 + 2.343 2.330 -0.042
ENSG00000184640 E036 338.6375490 0.0022658072 8.492328e-03 2.501821e-02 17 77402556 77402703 148 + 2.491 2.473 -0.059
ENSG00000184640 E037 0.0000000       17 77405077 77405140 64 +      
ENSG00000184640 E038 0.2214452 0.0384268356 1.000000e+00   17 77419802 77419880 79 + 0.000 0.086 28.625
ENSG00000184640 E039 0.0000000       17 77426956 77427201 246 +      
ENSG00000184640 E040 0.0000000       17 77450567 77450575 9 +      
ENSG00000184640 E041 0.0000000       17 77450576 77450736 161 +      
ENSG00000184640 E042 0.0000000       17 77450737 77450761 25 +      
ENSG00000184640 E043 0.0000000       17 77450762 77450786 25 +      
ENSG00000184640 E044 0.0000000       17 77450848 77450978 131 +      
ENSG00000184640 E045 0.0000000       17 77451244 77451366 123 +      
ENSG00000184640 E046 0.0000000       17 77451367 77451528 162 +      
ENSG00000184640 E047 0.0000000       17 77453825 77453992 168 +      
ENSG00000184640 E048 0.0000000       17 77453993 77453996 4 +      
ENSG00000184640 E049 0.0000000       17 77453997 77454026 30 +      
ENSG00000184640 E050 0.0000000       17 77454027 77454071 45 +      
ENSG00000184640 E051 0.0000000       17 77454072 77454079 8 +      
ENSG00000184640 E052 0.0000000       17 77454080 77454108 29 +      
ENSG00000184640 E053 0.0000000       17 77454109 77454363 255 +      
ENSG00000184640 E054 0.0000000       17 77454364 77454449 86 +      
ENSG00000184640 E055 0.0000000       17 77456366 77456506 141 +      
ENSG00000184640 E056 0.0000000       17 77466403 77466560 158 +      
ENSG00000184640 E057 0.0000000       17 77475243 77475903 661 +      
ENSG00000184640 E058 0.0000000       17 77481910 77481912 3 +      
ENSG00000184640 E059 0.5483223 0.0203331633 8.437482e-01 9.027201e-01 17 77481913 77482012 100 + 0.171 0.158 -0.142
ENSG00000184640 E060 0.3666179 0.0297475842 4.987359e-01 6.351556e-01 17 77482013 77482143 131 + 0.171 0.086 -1.142
ENSG00000184640 E061 398.9422928 0.0025728860 3.527180e-03 1.180506e-02 17 77482144 77482335 192 + 2.568 2.542 -0.088
ENSG00000184640 E062 1.0684302 0.0121989077 5.112174e-01 6.462973e-01 17 77482336 77484128 1793 + 0.171 0.321 1.177
ENSG00000184640 E063 169.0411200 0.0035359149 1.221380e-04 6.235893e-04 17 77487424 77487428 5 + 2.246 2.151 -0.316
ENSG00000184640 E064 252.3277533 0.0024682544 5.261530e-05 2.948097e-04 17 77487429 77487481 53 + 2.404 2.330 -0.248
ENSG00000184640 E065 311.8424630 0.0002033950 8.540408e-08 8.784162e-07 17 77487482 77487552 71 + 2.484 2.424 -0.200
ENSG00000184640 E066 0.6997360 0.0167828911 2.162226e-01 3.458659e-01 17 77488029 77488239 211 + 0.000 0.273 30.620
ENSG00000184640 E067 351.2179037 0.0001735892 3.663586e-07 3.330241e-06 17 77488240 77488321 82 + 2.526 2.478 -0.158
ENSG00000184640 E068 477.7909240 0.0011631840 2.087070e-03 7.493814e-03 17 77488727 77488864 138 + 2.633 2.623 -0.034
ENSG00000184640 E069 361.7802965 0.0006857210 6.997795e-02 1.433386e-01 17 77490742 77490807 66 + 2.491 2.509 0.059
ENSG00000184640 E070 350.7322120 0.0001959626 1.525560e-01 2.651567e-01 17 77490808 77490859 52 + 2.470 2.499 0.095
ENSG00000184640 E071 1.5177927 0.2901017347 2.479649e-01 3.835230e-01 17 77490860 77491529 670 + 0.536 0.278 -1.441
ENSG00000184640 E072 489.0750057 0.0007691039 1.454809e-01 2.555108e-01 17 77492621 77492716 96 + 2.613 2.643 0.099
ENSG00000184640 E073 454.7439935 0.0001359422 2.410575e-01 3.754172e-01 17 77492980 77493076 97 + 2.576 2.614 0.124
ENSG00000184640 E074 3.7985927 0.0043537730 8.212653e-01 8.873202e-01 17 77493077 77493285 209 + 0.642 0.653 0.046
ENSG00000184640 E075 5.2849237 0.0182764931 2.938838e-01 4.349404e-01 17 77496214 77496389 176 + 0.833 0.730 -0.413
ENSG00000184640 E076 5.8174546 0.0030315493 4.233835e-02 9.534016e-02 17 77497075 77497314 240 + 0.942 0.730 -0.824
ENSG00000184640 E077 331.6305413 0.0001715901 7.839642e-01 8.614230e-01 17 77497315 77497366 52 + 2.420 2.485 0.218
ENSG00000184640 E078 2.2153255 0.0067896057 4.355910e-01 5.778081e-01 17 77497367 77497614 248 + 0.534 0.440 -0.467
ENSG00000184640 E079 2805.6851426 0.0048178985 3.502863e-12 7.863573e-11 17 77498523 77500596 2074 + 3.209 3.451 0.803