ENSG00000184575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332707 ENSG00000184575 HEK293_OSMI2_2hA HEK293_TMG_2hB XPOT protein_coding protein_coding 56.44418 14.43919 98.57274 0.2484662 2.079195 2.770347 33.056223 10.40524975 59.040105 0.75032500 2.0824737 2.503242 0.6123708 0.722200000 0.59876667 -0.12343333 3.492927e-01 3.327002e-09 FALSE  
ENST00000400935 ENSG00000184575 HEK293_OSMI2_2hA HEK293_TMG_2hB XPOT protein_coding protein_coding 56.44418 14.43919 98.57274 0.2484662 2.079195 2.770347 3.798316 0.04177318 5.739833 0.02267881 0.8221119 6.795171 0.0465375 0.002866667 0.05846667 0.05560000 3.327002e-09 3.327002e-09 FALSE  
ENST00000538086 ENSG00000184575 HEK293_OSMI2_2hA HEK293_TMG_2hB XPOT protein_coding nonsense_mediated_decay 56.44418 14.43919 98.57274 0.2484662 2.079195 2.770347 4.356140 0.87652960 9.312702 0.87652960 1.7841862 3.394508 0.0646375 0.061200000 0.09386667 0.03266667 2.537631e-01 3.327002e-09 FALSE  
ENST00000542958 ENSG00000184575 HEK293_OSMI2_2hA HEK293_TMG_2hB XPOT protein_coding retained_intron 56.44418 14.43919 98.57274 0.2484662 2.079195 2.770347 13.878054 2.94691988 22.206175 0.94063877 0.5553331 2.909443 0.2509875 0.202100000 0.22570000 0.02360000 8.331327e-01 3.327002e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184575 E001 15.5765677 0.0168122246 1.207401e-05 7.871523e-05 12 64404392 64404464 73 + 1.177 0.407 -3.175
ENSG00000184575 E002 264.4131999 0.0143691507 4.158830e-04 1.835347e-03 12 64404465 64404804 340 + 2.336 2.124 -0.709
ENSG00000184575 E003 3.4545094 0.0087776594 3.135417e-01 4.561546e-01 12 64405046 64405272 227 + 0.587 0.407 -0.887
ENSG00000184575 E004 2.1247743 0.0928974430 8.987837e-01 9.394414e-01 12 64405273 64405321 49 + 0.422 0.406 -0.088
ENSG00000184575 E005 0.9048261 0.4206284799 5.550829e-01 6.839810e-01 12 64405322 64405337 16 + 0.262 0.000 -10.293
ENSG00000184575 E006 1.5574093 0.0556457736 6.161431e-01 7.342442e-01 12 64409657 64409961 305 + 0.348 0.250 -0.658
ENSG00000184575 E007 315.9826742 0.0010676689 7.867372e-12 1.665493e-10 12 64409962 64410095 134 + 2.412 2.213 -0.664
ENSG00000184575 E008 297.7734439 0.0001711996 1.104426e-15 4.144813e-14 12 64414907 64414989 83 + 2.388 2.171 -0.722
ENSG00000184575 E009 250.4373167 0.0004602112 2.375210e-10 3.926152e-09 12 64416698 64416754 57 + 2.310 2.124 -0.622
ENSG00000184575 E010 303.5044569 0.0001924376 3.228924e-15 1.142529e-13 12 64418046 64418115 70 + 2.396 2.187 -0.699
ENSG00000184575 E011 524.8090440 0.0001187765 3.921777e-20 2.538329e-18 12 64418876 64419094 219 + 2.629 2.452 -0.590
ENSG00000184575 E012 452.8139174 0.0090404651 7.732535e-05 4.153829e-04 12 64420070 64420254 185 + 2.565 2.388 -0.592
ENSG00000184575 E013 509.9386192 0.0016889453 6.327154e-14 1.848643e-12 12 64420353 64420521 169 + 2.619 2.418 -0.671
ENSG00000184575 E014 554.6498886 0.0024779614 8.074001e-11 1.447247e-09 12 64421235 64421471 237 + 2.653 2.468 -0.617
ENSG00000184575 E015 230.6268255 0.0053299999 2.009308e-03 7.255177e-03 12 64423005 64423043 39 + 2.266 2.143 -0.411
ENSG00000184575 E016 0.2987644 0.0275355940 1.000000e+00   12 64423180 64423181 2 + 0.105 0.000 -8.694
ENSG00000184575 E017 286.8853353 0.0023638336 1.107222e-03 4.327267e-03 12 64423182 64423244 63 + 2.356 2.262 -0.313
ENSG00000184575 E018 391.8979847 0.0006166564 3.298941e-05 1.942612e-04 12 64424599 64424703 105 + 2.489 2.406 -0.276
ENSG00000184575 E019 250.1209056 0.0001749227 7.369637e-04 3.032300e-03 12 64424704 64424723 20 + 2.294 2.221 -0.245
ENSG00000184575 E020 418.6364835 0.0002058460 1.512945e-02 4.078009e-02 12 64425038 64425138 101 + 2.509 2.482 -0.088
ENSG00000184575 E021 272.6781058 0.0002453516 1.112381e-01 2.073737e-01 12 64425139 64425182 44 + 2.321 2.305 -0.051
ENSG00000184575 E022 31.8420416 0.0040506762 4.340922e-01 5.764779e-01 12 64425183 64425337 155 + 1.408 1.371 -0.128
ENSG00000184575 E023 409.9800362 0.0002191322 3.244260e-02 7.670720e-02 12 64425338 64425457 120 + 2.498 2.478 -0.068
ENSG00000184575 E024 1.9144648 0.0433580778 7.690228e-02 1.545445e-01 12 64425619 64425814 196 + 0.443 0.000 -11.394
ENSG00000184575 E025 385.1256489 0.0007075007 6.037474e-02 1.272480e-01 12 64425815 64425909 95 + 2.472 2.451 -0.067
ENSG00000184575 E026 289.0920821 0.0005038762 2.592489e-01 3.966399e-01 12 64428051 64428120 70 + 2.344 2.342 -0.008
ENSG00000184575 E027 592.6783732 0.0001933658 2.945939e-02 7.089495e-02 12 64430049 64430287 239 + 2.641 2.714 0.245
ENSG00000184575 E028 797.5183589 0.0001747685 5.965155e-02 1.260252e-01 12 64431538 64431823 286 + 2.772 2.835 0.211
ENSG00000184575 E029 642.3602680 0.0010237395 5.066436e-04 2.185186e-03 12 64433414 64433603 190 + 2.669 2.781 0.373
ENSG00000184575 E030 490.3320082 0.0010252414 2.194730e-06 1.691833e-05 12 64434507 64434623 117 + 2.544 2.694 0.499
ENSG00000184575 E031 454.3856422 0.0028356215 5.683482e-08 6.051701e-07 12 64434794 64434909 116 + 2.497 2.706 0.696
ENSG00000184575 E032 307.8194668 0.0001729215 9.581088e-13 2.360656e-11 12 64435627 64435674 48 + 2.329 2.537 0.695
ENSG00000184575 E033 333.6742545 0.0001590838 1.999430e-16 8.274049e-15 12 64439244 64439315 72 + 2.358 2.584 0.752
ENSG00000184575 E034 255.1337882 0.0002212036 1.300678e-16 5.517455e-15 12 64445075 64445131 57 + 2.234 2.488 0.846
ENSG00000184575 E035 1547.7190480 0.0096653402 3.437593e-07 3.142604e-06 12 64448105 64451125 3021 + 3.014 3.271 0.853