ENSG00000184500

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394236 ENSG00000184500 HEK293_OSMI2_2hA HEK293_TMG_2hB PROS1 protein_coding protein_coding 2.701174 1.141793 4.160452 0.03697963 0.1228005 1.856322 1.82881033 0.65256530 3.1696717 0.32993620 0.11462385 2.262743 0.61603750 0.5583667 0.76180000 0.2034333 0.88569702 0.04456674 FALSE TRUE
ENST00000407433 ENSG00000184500 HEK293_OSMI2_2hA HEK293_TMG_2hB PROS1 protein_coding protein_coding 2.701174 1.141793 4.160452 0.03697963 0.1228005 1.856322 0.05292144 0.00000000 0.0000000 0.00000000 0.00000000 0.000000 0.06185000 0.0000000 0.00000000 0.0000000   0.04456674 FALSE TRUE
ENST00000647936 ENSG00000184500 HEK293_OSMI2_2hA HEK293_TMG_2hB PROS1 protein_coding protein_coding 2.701174 1.141793 4.160452 0.03697963 0.1228005 1.856322 0.01799042 0.07496708 0.0000000 0.07496708 0.00000000 -3.086904 0.01055417 0.0670000 0.00000000 -0.0670000 0.52266907 0.04456674 FALSE TRUE
ENST00000648381 ENSG00000184500 HEK293_OSMI2_2hA HEK293_TMG_2hB PROS1 protein_coding processed_transcript 2.701174 1.141793 4.160452 0.03697963 0.1228005 1.856322 0.17631433 0.36410097 0.1298618 0.36410097 0.12986182 -1.419426 0.10379167 0.3333333 0.03063333 -0.3027000 0.96144327 0.04456674 FALSE TRUE
ENST00000650591 ENSG00000184500 HEK293_OSMI2_2hA HEK293_TMG_2hB PROS1 protein_coding protein_coding 2.701174 1.141793 4.160452 0.03697963 0.1228005 1.856322 0.45892017 0.05015945 0.8609181 0.05015945 0.06446698 3.855674 0.15619167 0.0413000 0.20756667 0.1662667 0.04456674 0.04456674 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184500 E001 0.0000000       3 93873051 93873108 58 -      
ENSG00000184500 E002 0.0000000       3 93873109 93873123 15 -      
ENSG00000184500 E003 0.2214452 0.0398467310 1.247282e-01   3 93873124 93873131 8 - 0.000 0.209 11.285
ENSG00000184500 E004 0.2214452 0.0398467310 1.247282e-01   3 93873132 93873135 4 - 0.000 0.209 13.853
ENSG00000184500 E005 4.1611477 0.0039408134 1.183769e-03 4.586218e-03 3 93873136 93873190 55 - 0.485 0.956 1.967
ENSG00000184500 E006 28.1390186 0.0212408139 7.848718e-04 3.205528e-03 3 93873191 93873413 223 - 1.305 1.618 1.077
ENSG00000184500 E007 65.2095748 0.0004070254 4.646844e-07 4.136892e-06 3 93873414 93874243 830 - 1.688 1.917 0.771
ENSG00000184500 E008 20.6256061 0.0009956411 5.750718e-01 7.007908e-01 3 93874244 93874405 162 - 1.263 1.318 0.193
ENSG00000184500 E009 15.1351922 0.0033777329 1.353616e-01 2.416177e-01 3 93876966 93877002 37 - 1.187 1.037 -0.543
ENSG00000184500 E010 17.8141510 0.0011435812 3.855284e-01 5.297234e-01 3 93877003 93877050 48 - 1.237 1.164 -0.260
ENSG00000184500 E011 25.5392057 0.0008213521 3.546063e-01 4.989239e-01 3 93877051 93877191 141 - 1.383 1.318 -0.226
ENSG00000184500 E012 21.6982175 0.0067015232 8.828809e-01 9.290625e-01 3 93879163 93879314 152 - 1.297 1.292 -0.021
ENSG00000184500 E013 0.0000000       3 93881131 93881318 188 -      
ENSG00000184500 E014 25.4796886 0.0017936910 8.684909e-01 9.194634e-01 3 93884728 93884896 169 - 1.360 1.355 -0.018
ENSG00000184500 E015 25.0491810 0.0008375386 9.541308e-01 9.752632e-01 3 93886336 93886503 168 - 1.354 1.366 0.044
ENSG00000184500 E016 23.5540280 0.0009002647 9.209420e-01 9.541154e-01 3 93892933 93893122 190 - 1.327 1.343 0.056
ENSG00000184500 E017 19.8690933 0.0016968385 4.590724e-01 5.993046e-01 3 93896576 93896691 116 - 1.275 1.216 -0.206
ENSG00000184500 E018 18.7619508 0.0011001511 5.197551e-01 6.538337e-01 3 93898448 93898569 122 - 1.250 1.200 -0.179
ENSG00000184500 E019 18.5933719 0.0150903697 5.590653e-01 6.872262e-01 3 93900804 93900929 126 - 1.242 1.185 -0.204
ENSG00000184500 E020 11.9523054 0.0517457069 7.411996e-01 8.304583e-01 3 93905784 93905820 37 - 1.067 1.013 -0.197
ENSG00000184500 E021 10.2756355 0.0460232137 5.249001e-01 6.583256e-01 3 93905821 93905828 8 - 1.019 0.924 -0.354
ENSG00000184500 E022 16.6534159 0.0011603711 5.117419e-02 1.112516e-01 3 93905829 93905915 87 - 1.229 1.037 -0.688
ENSG00000184500 E023 8.6466939 0.0019720979 1.428784e-01 2.519607e-01 3 93906021 93906039 19 - 0.965 0.774 -0.733
ENSG00000184500 E024 15.3821798 0.0031038536 4.612701e-01 6.012497e-01 3 93906040 93906143 104 - 1.173 1.105 -0.241
ENSG00000184500 E025 15.2716674 0.0012805455 7.496790e-02 1.514847e-01 3 93910619 93910705 87 - 1.192 1.012 -0.651
ENSG00000184500 E026 0.0000000       3 93910706 93911157 452 -      
ENSG00000184500 E027 0.0000000       3 93923775 93923894 120 -      
ENSG00000184500 E028 8.0269276 0.0035299703 4.039980e-01 5.477357e-01 3 93924240 93924264 25 - 0.923 0.817 -0.404
ENSG00000184500 E029 18.3731147 0.0012627074 3.614946e-04 1.624732e-03 3 93927250 93927407 158 - 1.298 0.925 -1.345
ENSG00000184500 E030 2.1089684 0.0068196753 1.331886e-01 2.385751e-01 3 93928702 93928797 96 - 0.509 0.209 -1.849
ENSG00000184500 E031 0.2903454 0.2938028667 1.000000e+00   3 93958511 93958754 244 - 0.128 0.000 -12.334
ENSG00000184500 E032 0.0000000       3 93968492 93968723 232 -      
ENSG00000184500 E033 0.1451727 0.0432186440 1.000000e+00   3 93973563 93973637 75 - 0.069 0.000 -11.514
ENSG00000184500 E034 12.1844850 0.0016222435 3.247168e-02 7.675857e-02 3 93973674 93973933 260 - 1.108 0.856 -0.935
ENSG00000184500 E035 0.0000000       3 93978962 93979055 94 -      
ENSG00000184500 E036 0.1472490 0.0437121322 1.000000e+00   3 93979644 93980003 360 - 0.069 0.000 -11.514