ENSG00000184470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400521 ENSG00000184470 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD2 protein_coding protein_coding 52.62725 95.05379 28.64038 2.953191 0.3274967 -1.730342 30.682245 63.353921 13.978719 3.1055417 0.63410793 -2.1793978 0.5349583 0.66680000 0.48830000 -0.17850000 0.004802378 0.004802378 TRUE TRUE
MSTRG.21646.17 ENSG00000184470 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD2 protein_coding   52.62725 95.05379 28.64038 2.953191 0.3274967 -1.730342 4.762727 3.287721 4.859242 2.5329798 0.43553114 0.5622281 0.1317500 0.03316667 0.16973333 0.13656667 0.251571776 0.004802378 FALSE TRUE
MSTRG.21646.22 ENSG00000184470 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD2 protein_coding   52.62725 95.05379 28.64038 2.953191 0.3274967 -1.730342 5.006243 6.917766 4.055622 0.8004017 0.44269947 -0.7689140 0.1042542 0.07280000 0.14136667 0.06856667 0.008005800 0.004802378 FALSE TRUE
MSTRG.21646.6 ENSG00000184470 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD2 protein_coding   52.62725 95.05379 28.64038 2.953191 0.3274967 -1.730342 2.588405 4.444742 1.636431 0.3617574 0.05971217 -1.4360000 0.0504750 0.04686667 0.05716667 0.01030000 0.534317603 0.004802378 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184470 E001 0.6934063 0.1754647316 4.949630e-01 6.318470e-01 22 19875517 19875517 1 - 0.000 0.212 9.909
ENSG00000184470 E002 0.6934063 0.1754647316 4.949630e-01 6.318470e-01 22 19875518 19875518 1 - 0.000 0.212 11.615
ENSG00000184470 E003 0.8416995 0.0545073880 3.295001e-01 4.730219e-01 22 19875519 19875521 3 - 0.000 0.252 12.446
ENSG00000184470 E004 3.3012087 0.0949223037 1.298276e-01 2.339193e-01 22 19875522 19875523 2 - 0.223 0.583 2.075
ENSG00000184470 E005 81.2224883 0.0045714135 1.128686e-01 2.097342e-01 22 19875524 19875570 47 - 1.704 1.801 0.329
ENSG00000184470 E006 184.4109700 0.0018065866 3.658225e-03 1.217782e-02 22 19875571 19875640 70 - 2.037 2.157 0.401
ENSG00000184470 E007 219.1074606 0.0021195218 8.563510e-04 3.460088e-03 22 19875641 19875691 51 - 2.099 2.232 0.446
ENSG00000184470 E008 246.6724846 0.0010700918 1.796699e-04 8.766108e-04 22 19875692 19875760 69 - 2.154 2.283 0.434
ENSG00000184470 E009 202.3830867 0.0002237926 3.274608e-05 1.930255e-04 22 19875761 19875807 47 - 2.053 2.197 0.484
ENSG00000184470 E010 57.9161122 0.0009921033 2.335356e-06 1.790586e-05 22 19875808 19877039 1232 - 1.841 1.582 -0.879
ENSG00000184470 E011 282.5041742 0.0012663038 4.713681e-05 2.672671e-04 22 19877040 19877108 69 - 2.204 2.342 0.460
ENSG00000184470 E012 450.3691793 0.0014411639 2.225814e-03 7.923368e-03 22 19877109 19877212 104 - 2.448 2.536 0.294
ENSG00000184470 E013 275.9265452 0.0004611101 2.909269e-01 4.317446e-01 22 19877213 19877234 22 - 2.285 2.315 0.101
ENSG00000184470 E014 456.5758239 0.0016772132 6.702219e-01 7.767174e-01 22 19878090 19878187 98 - 2.519 2.531 0.042
ENSG00000184470 E015 409.8146940 0.0012311666 4.630202e-01 6.028755e-01 22 19878366 19878437 72 - 2.464 2.485 0.068
ENSG00000184470 E016 434.0509933 0.0001442056 6.366901e-02 1.328111e-01 22 19880179 19880271 93 - 2.471 2.512 0.136
ENSG00000184470 E017 441.7464001 0.0001663378 1.829654e-02 4.777903e-02 22 19880622 19880717 96 - 2.469 2.522 0.175
ENSG00000184470 E018 5.1582976 0.0285262411 6.307580e-01 7.458894e-01 22 19880718 19880855 138 - 0.755 0.678 -0.318
ENSG00000184470 E019 4.3770763 0.0037832809 9.136319e-01 9.492942e-01 22 19880856 19880945 90 - 0.639 0.619 -0.084
ENSG00000184470 E020 4.0501000 0.0549841099 5.445798e-01 6.750247e-01 22 19880946 19881035 90 - 0.701 0.583 -0.506
ENSG00000184470 E021 3.0579423 0.1045438918 8.212310e-01 8.872982e-01 22 19881036 19881080 45 - 0.566 0.505 -0.285
ENSG00000184470 E022 4.5963590 0.0034549684 3.928315e-01 5.367262e-01 22 19881081 19881369 289 - 0.755 0.619 -0.570
ENSG00000184470 E023 460.9281572 0.0001353052 5.913873e-02 1.251581e-01 22 19883325 19883461 137 - 2.498 2.538 0.134
ENSG00000184470 E024 22.9135244 0.0144042200 4.847604e-02 1.064671e-01 22 19883462 19884504 1043 - 1.044 1.278 0.839
ENSG00000184470 E025 3.6849307 0.0051968997 4.687523e-02 1.036071e-01 22 19891438 19891760 323 - 0.804 0.485 -1.382
ENSG00000184470 E026 15.8801222 0.0087291065 1.042964e-01 1.970269e-01 22 19893902 19894257 356 - 1.249 1.075 -0.622
ENSG00000184470 E027 69.1940460 0.0004280123 4.188838e-02 9.452014e-02 22 19894258 19895015 758 - 1.802 1.693 -0.366
ENSG00000184470 E028 57.5247081 0.0004237067 9.034802e-01 9.425873e-01 22 19895016 19895200 185 - 1.642 1.634 -0.029
ENSG00000184470 E029 16.7119302 0.0065734786 1.797367e-02 4.707867e-02 22 19895201 19895320 120 - 0.847 1.152 1.127
ENSG00000184470 E030 598.6015862 0.0001285758 3.303701e-01 4.739603e-01 22 19895407 19895581 175 - 2.662 2.642 -0.065
ENSG00000184470 E031 454.0400957 0.0001269831 3.814335e-01 5.257355e-01 22 19898039 19898130 92 - 2.542 2.522 -0.067
ENSG00000184470 E032 270.1082478 0.0005615189 3.550694e-02 8.262723e-02 22 19899049 19899068 20 - 2.353 2.291 -0.207
ENSG00000184470 E033 13.5034514 0.0036171177 2.901319e-01 4.309193e-01 22 19910935 19911071 137 - 1.138 1.020 -0.427
ENSG00000184470 E034 1.8746422 0.0074273514 3.618460e-01 5.062499e-01 22 19911258 19911376 119 - 0.223 0.411 1.236
ENSG00000184470 E035 434.9820895 0.0004165504 2.589288e-02 6.372296e-02 22 19911377 19911447 71 - 2.552 2.499 -0.175
ENSG00000184470 E036 2.8366981 0.0054284445 5.688548e-01 6.954738e-01 22 19914900 19915213 314 - 0.566 0.462 -0.499
ENSG00000184470 E037 433.5611674 0.0003767166 7.077135e-03 2.142719e-02 22 19915214 19915276 63 - 2.557 2.495 -0.209
ENSG00000184470 E038 444.8995777 0.0012873150 1.124298e-03 4.384596e-03 22 19915765 19915843 79 - 2.588 2.501 -0.291
ENSG00000184470 E039 0.9545924 0.0132287788 3.144430e-01 4.571571e-01 22 19915844 19916366 523 - 0.000 0.253 13.012
ENSG00000184470 E040 486.9969760 0.0005847190 1.571189e-03 5.865510e-03 22 19918143 19918217 75 - 2.615 2.542 -0.242
ENSG00000184470 E041 0.4772466 0.0207910714 5.387250e-01 6.701325e-01 22 19918218 19918221 4 - 0.223 0.119 -1.086
ENSG00000184470 E042 535.4529027 0.0019597741 4.339972e-03 1.409509e-02 22 19918860 19919004 145 - 2.663 2.583 -0.267
ENSG00000184470 E043 314.3748207 0.0008398978 1.900678e-01 3.138616e-01 22 19919543 19919599 57 - 2.399 2.359 -0.130
ENSG00000184470 E044 178.7446071 0.0006173453 2.820886e-01 4.220436e-01 22 19931030 19931095 66 - 2.154 2.114 -0.133
ENSG00000184470 E045 16.6034027 0.0012128262 3.559318e-02 8.279707e-02 22 19931096 19931098 3 - 1.281 1.076 -0.731
ENSG00000184470 E046 0.2965864 0.1861376202 1.000000e+00   22 19932357 19932553 197 - 0.000 0.117 10.572
ENSG00000184470 E047 0.0000000       22 19933434 19933526 93 -      
ENSG00000184470 E048 0.3697384 0.0246597741 1.000000e+00 1.000000e+00 22 19937983 19938179 197 - 0.000 0.119 11.480
ENSG00000184470 E049 21.5140787 0.0090410168 7.381354e-02 1.496149e-01 22 19941701 19941740 40 - 1.364 1.189 -0.614
ENSG00000184470 E050 8.2808485 0.0750107072 3.429801e-01 4.870113e-01 22 19941741 19941820 80 - 0.986 0.819 -0.638