ENSG00000184445

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423927 ENSG00000184445 HEK293_OSMI2_2hA HEK293_TMG_2hB KNTC1 protein_coding protein_coding 11.70526 5.483665 16.55545 0.4464964 0.2918894 1.592337 1.6806178 0.69572671 2.6105264 0.18977973 0.10425972 1.8926751 0.14024167 0.129500000 0.15753333 0.02803333 7.300122e-01 1.548726e-09 FALSE FALSE
ENST00000535410 ENSG00000184445 HEK293_OSMI2_2hA HEK293_TMG_2hB KNTC1 protein_coding processed_transcript 11.70526 5.483665 16.55545 0.4464964 0.2918894 1.592337 0.3083812 0.71425880 0.1668554 0.12272936 0.08342773 -2.0339354 0.03984167 0.130300000 0.01010000 -0.12020000 1.788202e-03 1.548726e-09   FALSE
MSTRG.8222.1 ENSG00000184445 HEK293_OSMI2_2hA HEK293_TMG_2hB KNTC1 protein_coding   11.70526 5.483665 16.55545 0.4464964 0.2918894 1.592337 4.8501557 0.69067018 8.9610991 0.21087385 0.37320167 3.6784774 0.34686667 0.126866667 0.54106667 0.41420000 1.482034e-05 1.548726e-09 FALSE TRUE
MSTRG.8222.2 ENSG00000184445 HEK293_OSMI2_2hA HEK293_TMG_2hB KNTC1 protein_coding   11.70526 5.483665 16.55545 0.4464964 0.2918894 1.592337 0.5114540 0.05656773 1.0571413 0.03422318 0.10541434 4.0027845 0.03664583 0.009533333 0.06393333 0.05440000 1.959090e-04 1.548726e-09 FALSE TRUE
MSTRG.8222.6 ENSG00000184445 HEK293_OSMI2_2hA HEK293_TMG_2hB KNTC1 protein_coding   11.70526 5.483665 16.55545 0.4464964 0.2918894 1.592337 0.2653936 0.29995825 0.0000000 0.04567055 0.00000000 -4.9540020 0.03534583 0.056333333 0.00000000 -0.05633333 1.548726e-09 1.548726e-09 FALSE TRUE
MSTRG.8222.7 ENSG00000184445 HEK293_OSMI2_2hA HEK293_TMG_2hB KNTC1 protein_coding   11.70526 5.483665 16.55545 0.4464964 0.2918894 1.592337 2.6134416 2.09879606 2.6005163 0.54319856 0.18538357 0.3079156 0.26415000 0.372400000 0.15713333 -0.21526667 4.990473e-03 1.548726e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184445 E001 1.3640767 0.0099729122 6.324719e-01 7.473153e-01 12 122527198 122527245 48 + 0.333 0.239 -0.650
ENSG00000184445 E002 1.5155921 0.0088663850 5.406143e-01 6.717300e-01 12 122527246 122527247 2 + 0.361 0.239 -0.820
ENSG00000184445 E003 1.5155921 0.0088663850 5.406143e-01 6.717300e-01 12 122527248 122527248 1 + 0.361 0.239 -0.820
ENSG00000184445 E004 23.9934919 0.0007876903 2.167881e-01 3.465459e-01 12 122527249 122527351 103 + 1.317 1.216 -0.356
ENSG00000184445 E005 2.2433364 0.0065373902 1.167339e-07 1.171277e-06 12 122527456 122527680 225 + 0.110 0.958 4.809
ENSG00000184445 E006 0.0000000       12 122529991 122530021 31 +      
ENSG00000184445 E007 35.9360344 0.0061618495 1.190225e-03 4.608122e-03 12 122530022 122530192 171 + 1.508 1.216 -1.015
ENSG00000184445 E008 33.5739839 0.0271887680 9.833735e-04 3.902819e-03 12 122534664 122534784 121 + 1.490 1.084 -1.423
ENSG00000184445 E009 34.7769808 0.0005559993 5.918647e-10 9.158457e-09 12 122538339 122538454 116 + 1.522 0.882 -2.287
ENSG00000184445 E010 34.2354949 0.0006404637 4.649563e-13 1.203670e-11 12 122539676 122539754 79 + 1.524 0.670 -3.142
ENSG00000184445 E011 25.3416115 0.0007208120 7.549476e-09 9.516438e-08 12 122542050 122542127 78 + 1.394 0.670 -2.694
ENSG00000184445 E012 17.0413694 0.0011253737 4.089827e-05 2.352172e-04 12 122543600 122543634 35 + 1.223 0.670 -2.096
ENSG00000184445 E013 26.8829187 0.0007120586 1.118444e-03 4.365092e-03 12 122544159 122544269 111 + 1.389 1.080 -1.092
ENSG00000184445 E014 32.3602437 0.0006862713 6.486167e-06 4.500714e-05 12 122546176 122546269 94 + 1.477 1.053 -1.493
ENSG00000184445 E015 26.0718927 0.0007376090 3.429888e-09 4.605443e-08 12 122546622 122546674 53 + 1.407 0.670 -2.737
ENSG00000184445 E016 39.1301366 0.0055203061 1.676312e-08 1.981855e-07 12 122547415 122547530 116 + 1.567 0.992 -2.024
ENSG00000184445 E017 26.1042297 0.0366283856 4.712051e-03 1.512972e-02 12 122547915 122547969 55 + 1.385 0.994 -1.389
ENSG00000184445 E018 15.4929314 0.1136964739 9.052322e-02 1.759540e-01 12 122549766 122549779 14 + 1.164 0.845 -1.181
ENSG00000184445 E019 24.6410394 0.0544598765 7.384282e-03 2.221723e-02 12 122549780 122549864 85 + 1.360 0.964 -1.419
ENSG00000184445 E020 19.8163144 0.0009299675 2.762264e-06 2.084539e-05 12 122551319 122551362 44 + 1.286 0.670 -2.316
ENSG00000184445 E021 26.2562341 0.0019718556 4.416978e-05 2.521875e-04 12 122551458 122551523 66 + 1.389 0.959 -1.538
ENSG00000184445 E022 32.1117682 0.0006407867 2.097047e-05 1.294533e-04 12 122551621 122551696 76 + 1.472 1.080 -1.379
ENSG00000184445 E023 41.5463365 0.0005195928 6.867297e-09 8.727954e-08 12 122557384 122557509 126 + 1.590 1.080 -1.782
ENSG00000184445 E024 35.6925464 0.0006434946 1.765309e-04 8.634302e-04 12 122557600 122557689 90 + 1.509 1.196 -1.089
ENSG00000184445 E025 26.5473706 0.0016349458 6.803848e-04 2.827491e-03 12 122561921 122561974 54 + 1.386 1.053 -1.181
ENSG00000184445 E026 25.9888285 0.0007341075 2.074138e-03 7.453891e-03 12 122562638 122562699 62 + 1.373 1.080 -1.037
ENSG00000184445 E027 30.3661690 0.0007737619 9.549704e-05 5.009150e-04 12 122568261 122568372 112 + 1.444 1.080 -1.282
ENSG00000184445 E028 34.1833842 0.0006618393 9.899280e-05 5.171204e-04 12 122569681 122569824 144 + 1.491 1.153 -1.180
ENSG00000184445 E029 25.9598091 0.0506012126 4.999813e-02 1.091737e-01 12 122570876 122570932 57 + 1.368 1.112 -0.905
ENSG00000184445 E030 38.6612368 0.0005343684 9.113670e-06 6.114088e-05 12 122571025 122571126 102 + 1.546 1.175 -1.290
ENSG00000184445 E031 41.0097471 0.0015178293 2.093218e-06 1.621433e-05 12 122572937 122573056 120 + 1.575 1.175 -1.390
ENSG00000184445 E032 43.2551373 0.0046017465 2.430882e-04 1.146322e-03 12 122573142 122573285 144 + 1.588 1.287 -1.038
ENSG00000184445 E033 38.1666684 0.0020334640 5.763277e-05 3.197737e-04 12 122574282 122574380 99 + 1.537 1.196 -1.184
ENSG00000184445 E034 37.3363942 0.0017702246 8.945966e-05 4.724407e-04 12 122575543 122575646 104 + 1.528 1.196 -1.153
ENSG00000184445 E035 38.2050884 0.0101501624 1.839484e-02 4.799866e-02 12 122575800 122575899 100 + 1.527 1.318 -0.723
ENSG00000184445 E036 38.8760857 0.0005624211 1.133551e-02 3.196698e-02 12 122576895 122577029 135 + 1.532 1.348 -0.631
ENSG00000184445 E037 35.8367084 0.0047166464 4.614984e-02 1.023130e-01 12 122577672 122577791 120 + 1.493 1.334 -0.550
ENSG00000184445 E038 33.5364812 0.0068191722 2.375556e-01 3.713156e-01 12 122579905 122579977 73 + 1.455 1.362 -0.320
ENSG00000184445 E039 31.9550974 0.0027314113 2.460736e-01 3.813420e-01 12 122580603 122580670 68 + 1.433 1.349 -0.291
ENSG00000184445 E040 55.9646158 0.0006146736 5.051554e-03 1.607299e-02 12 122582705 122582985 281 + 1.682 1.513 -0.577
ENSG00000184445 E041 44.4250202 0.0005148586 4.801817e-06 3.433569e-05 12 122584278 122584450 173 + 1.606 1.253 -1.219
ENSG00000184445 E042 33.1350704 0.0006843455 7.292529e-03 2.198236e-02 12 122584893 122584990 98 + 1.468 1.253 -0.748
ENSG00000184445 E043 39.3339348 0.0005248161 1.082705e-01 2.029819e-01 12 122585636 122585774 139 + 1.520 1.415 -0.363
ENSG00000184445 E044 25.9738261 0.0029525969 2.512239e-02 6.212859e-02 12 122586701 122586757 57 + 1.360 1.154 -0.726
ENSG00000184445 E045 52.6776324 0.0005000254 5.798005e-04 2.459339e-03 12 122587711 122587874 164 + 1.662 1.439 -0.765
ENSG00000184445 E046 45.1289824 0.0005042367 7.895977e-04 3.221912e-03 12 122588712 122588816 105 + 1.600 1.363 -0.814
ENSG00000184445 E047 46.6216055 0.0005253111 3.279390e-01 4.714171e-01 12 122590607 122590735 129 + 1.583 1.532 -0.174
ENSG00000184445 E048 48.0389280 0.0005052073 3.109341e-01 4.533776e-01 12 122591337 122591453 117 + 1.569 1.647 0.268
ENSG00000184445 E049 22.0287582 0.0579687590 8.547674e-01 9.101559e-01 12 122592818 122593184 367 + 1.238 1.321 0.289
ENSG00000184445 E050 26.2701024 0.0052366036 8.188447e-01 8.855431e-01 12 122593416 122593912 497 + 1.329 1.363 0.120
ENSG00000184445 E051 27.3355872 0.0007672903 1.622594e-05 1.027529e-04 12 122593913 122594275 363 + 1.259 1.594 1.157
ENSG00000184445 E052 42.3756172 0.0005275862 7.618066e-01 8.455804e-01 12 122594276 122594385 110 + 1.524 1.560 0.122
ENSG00000184445 E053 5.4992157 0.0234065475 2.277414e-02 5.727759e-02 12 122597243 122597730 488 + 0.635 0.991 1.409
ENSG00000184445 E054 48.5810000 0.0080374053 3.036721e-01 4.456291e-01 12 122597731 122597938 208 + 1.569 1.665 0.327
ENSG00000184445 E055 36.6062518 0.0106826991 3.691620e-01 5.136035e-01 12 122601536 122601625 90 + 1.451 1.544 0.318
ENSG00000184445 E056 0.7448917 0.0723557926 4.086808e-01 5.522941e-01 12 122601851 122601951 101 + 0.236 0.000 -10.634
ENSG00000184445 E057 1.6378584 0.2035578681 1.938514e-02 5.016950e-02 12 122602397 122602568 172 + 0.198 0.729 2.912
ENSG00000184445 E058 62.4852525 0.0003771264 1.157409e-01 2.138716e-01 12 122602569 122602740 172 + 1.676 1.777 0.342
ENSG00000184445 E059 0.7437457 0.0157546284 8.545049e-01 9.099940e-01 12 122602823 122602828 6 + 0.198 0.239 0.349
ENSG00000184445 E060 36.2543253 0.0006349937 5.854544e-02 1.241383e-01 12 122602829 122602887 59 + 1.440 1.585 0.499
ENSG00000184445 E061 1.2617904 0.1187311238 5.423758e-02 1.166649e-01 12 122602888 122603026 139 + 0.198 0.592 2.333
ENSG00000184445 E062 85.1828228 0.0003339669 1.590958e-01 2.739024e-01 12 122603027 122603243 217 + 1.816 1.897 0.274
ENSG00000184445 E063 48.0137931 0.0004938492 6.568332e-01 7.662966e-01 12 122604564 122604637 74 + 1.582 1.625 0.146
ENSG00000184445 E064 82.8749405 0.0003646490 2.982014e-02 7.161082e-02 12 122604877 122605087 211 + 1.791 1.909 0.398
ENSG00000184445 E065 42.5469647 0.0015101349 5.318976e-03 1.680084e-02 12 122605306 122605358 53 + 1.485 1.682 0.673
ENSG00000184445 E066 46.4989608 0.0005232409 1.087063e-04 5.621729e-04 12 122605359 122605415 57 + 1.509 1.755 0.837
ENSG00000184445 E067 0.1482932 0.0422512647 8.117685e-02   12 122609197 122609383 187 + 0.000 0.239 12.732
ENSG00000184445 E068 35.2499085 0.0006522195 8.713747e-02 1.708029e-01 12 122609384 122609430 47 + 1.423 1.560 0.468
ENSG00000184445 E069 36.8162094 0.0032328659 8.816090e-01 9.281263e-01 12 122610822 122610860 39 + 1.466 1.494 0.096
ENSG00000184445 E070 38.3386247 0.0005752549 9.703904e-01 9.854647e-01 12 122610861 122610900 40 + 1.491 1.503 0.042
ENSG00000184445 E071 0.4762024 0.1990846976 4.763077e-01 6.149451e-01 12 122610901 122611765 865 + 0.110 0.240 1.354
ENSG00000184445 E072 0.4407149 0.0229243504 4.635343e-01 6.033210e-01 12 122612882 122613111 230 + 0.110 0.239 1.348
ENSG00000184445 E073 69.3023807 0.0011368152 6.993756e-04 2.896742e-03 12 122613112 122613230 119 + 1.699 1.889 0.642
ENSG00000184445 E074 0.1451727 0.0426060796 1.000000e+00   12 122613450 122613625 176 + 0.058 0.000 -8.311
ENSG00000184445 E075 54.9225729 0.0033653430 8.670454e-05 4.596333e-04 12 122613626 122613703 78 + 1.580 1.833 0.856
ENSG00000184445 E076 46.9616277 0.0007712235 1.242949e-08 1.506448e-07 12 122613704 122613761 58 + 1.483 1.827 1.171
ENSG00000184445 E077 60.5546727 0.0055570910 1.754627e-08 2.068119e-07 12 122614991 122615086 96 + 1.585 1.946 1.220
ENSG00000184445 E078 44.6889490 0.0025975424 1.389229e-06 1.118414e-05 12 122615470 122615526 57 + 1.468 1.789 1.091
ENSG00000184445 E079 0.0000000       12 122617407 122617501 95 +      
ENSG00000184445 E080 52.4039638 0.0033470512 4.992501e-05 2.814123e-04 12 122618343 122618397 55 + 1.553 1.820 0.905
ENSG00000184445 E081 62.6508556 0.0005833528 1.000729e-04 5.221868e-04 12 122618482 122618545 64 + 1.644 1.864 0.742
ENSG00000184445 E082 0.1482932 0.0422512647 8.117685e-02   12 122620042 122620478 437 + 0.000 0.239 12.732
ENSG00000184445 E083 81.2718818 0.0061310494 1.950362e-06 1.520669e-05 12 122620479 122620608 130 + 1.733 2.028 0.992
ENSG00000184445 E084 55.3655350 0.0137363922 6.423447e-07 5.559172e-06 12 122621881 122621970 90 + 1.537 1.934 1.345
ENSG00000184445 E085 64.1630293 0.0056087034 5.647092e-13 1.441424e-11 12 122622462 122622607 146 + 1.588 2.022 1.466
ENSG00000184445 E086 51.8805382 0.0013095809 1.201211e-22 1.030642e-20 12 122624598 122624688 91 + 1.455 1.991 1.817
ENSG00000184445 E087 40.1653032 0.0322780928 5.506357e-10 8.568073e-09 12 122626205 122626396 192 + 1.292 1.947 2.233