ENSG00000184368

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379643 ENSG00000184368 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D2 protein_coding protein_coding 7.822782 9.401464 7.839505 0.8405587 0.09526544 -0.2618175 6.1207056 7.6096034 5.422957 0.5527892 0.3964430 -0.4879783 0.7928333 0.81403333 0.6908000 -0.12323333 0.22607100 0.04061004 FALSE TRUE
ENST00000466145 ENSG00000184368 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D2 protein_coding processed_transcript 7.822782 9.401464 7.839505 0.8405587 0.09526544 -0.2618175 0.4455895 0.6520760 0.000000 0.3274779 0.0000000 -6.0489249 0.0481125 0.07226667 0.0000000 -0.07226667 0.20867065 0.04061004 FALSE TRUE
MSTRG.33983.5 ENSG00000184368 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP7D2 protein_coding   7.822782 9.401464 7.839505 0.8405587 0.09526544 -0.2618175 0.8054179 0.2737768 2.028292 0.2737768 0.2648301 2.8445327 0.1030667 0.02770000 0.2594667 0.23176667 0.04061004 0.04061004 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184368 E001 296.6483660 0.0019980930 5.777480e-15 1.969281e-13 X 20006713 20008037 1325 - 2.312 2.530 0.727
ENSG00000184368 E002 108.0270796 0.0003160511 7.834213e-04 3.200294e-03 X 20008038 20008338 301 - 1.942 2.066 0.417
ENSG00000184368 E003 49.7388741 0.0104633451 1.229185e-01 2.241159e-01 X 20008339 20008398 60 - 1.622 1.729 0.364
ENSG00000184368 E004 93.0098280 0.0003483352 6.553093e-01 7.652398e-01 X 20010777 20011052 276 - 1.948 1.971 0.080
ENSG00000184368 E005 68.7346836 0.0003838760 8.442278e-01 9.030242e-01 X 20012349 20012535 187 - 1.833 1.831 -0.004
ENSG00000184368 E006 43.4411784 0.0004940586 7.242624e-01 8.178388e-01 X 20013054 20013132 79 - 1.646 1.635 -0.038
ENSG00000184368 E007 33.9618822 0.0006055706 9.100458e-01 9.468196e-01 X 20013569 20013625 57 - 1.533 1.533 0.002
ENSG00000184368 E008 42.4671285 0.0007446779 5.359376e-01 6.677262e-01 X 20015223 20015327 105 - 1.642 1.615 -0.091
ENSG00000184368 E009 74.0555632 0.0003549447 7.343935e-01 8.253611e-01 X 20016094 20016325 232 - 1.868 1.862 -0.022
ENSG00000184368 E010 6.4619077 0.0063811145 7.083711e-01 8.060325e-01 X 20021348 20021549 202 - 0.835 0.891 0.214
ENSG00000184368 E011 77.4854010 0.0003915890 2.161717e-01 3.457969e-01 X 20024951 20025083 133 - 1.847 1.905 0.194
ENSG00000184368 E012 113.5202664 0.0003090487 4.352803e-02 9.751494e-02 X 20025681 20025952 272 - 2.083 2.024 -0.198
ENSG00000184368 E013 69.5721734 0.0003755899 4.003031e-03 1.315049e-02 X 20042502 20042629 128 - 1.906 1.793 -0.378
ENSG00000184368 E014 78.3939031 0.0037815845 3.537552e-03 1.183309e-02 X 20044364 20044500 137 - 1.966 1.832 -0.452
ENSG00000184368 E015 41.4991770 0.0040935805 5.878381e-02 1.245459e-01 X 20044501 20044524 24 - 1.682 1.575 -0.367
ENSG00000184368 E016 68.5876463 0.0004873857 1.063840e-03 4.180142e-03 X 20050824 20050946 123 - 1.910 1.780 -0.439
ENSG00000184368 E017 57.2223371 0.0022289303 7.509471e-02 1.516859e-01 X 20052878 20052988 111 - 1.804 1.722 -0.277
ENSG00000184368 E018 48.5677755 0.0112374522 1.278851e-01 2.312221e-01 X 20056680 20056791 112 - 1.744 1.644 -0.339
ENSG00000184368 E019 60.3560805 0.0091544479 2.103853e-02 5.367276e-02 X 20063414 20063577 164 - 1.857 1.718 -0.469
ENSG00000184368 E020 39.9163451 0.0078911305 3.111950e-03 1.059541e-02 X 20064728 20064805 78 - 1.713 1.515 -0.672
ENSG00000184368 E021 0.7655156 0.1989612203 5.076579e-01 6.431126e-01 X 20116531 20116749 219 - 0.335 0.187 -1.111
ENSG00000184368 E022 32.5459341 0.0225063387 5.288451e-02 1.142827e-01 X 20116750 20116907 158 - 1.614 1.435 -0.611