ENSG00000184319

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000427528 ENSG00000184319 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL23AP82 transcribed_unprocessed_pseudogene transcribed_unprocessed_pseudogene 30.81904 37.0771 33.95832 7.806808 0.5514198 -0.1267278 4.320272 4.282931 6.286160 3.3152015 1.7141809 0.5525091 0.13015000 0.09650000 0.1868667 0.09036667 6.831392e-01 1.219998e-11 FALSE TRUE
ENST00000651346 ENSG00000184319 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL23AP82 transcribed_unprocessed_pseudogene processed_transcript 30.81904 37.0771 33.95832 7.806808 0.5514198 -0.1267278 2.009638 1.032376 3.353451 0.1516951 0.1732669 1.6900673 0.06507917 0.02863333 0.0989000 0.07026667 1.219998e-11 1.219998e-11 FALSE FALSE
MSTRG.22394.3 ENSG00000184319 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL23AP82 transcribed_unprocessed_pseudogene   30.81904 37.0771 33.95832 7.806808 0.5514198 -0.1267278 15.072866 18.133821 13.769066 4.1279162 1.5712086 -0.3970002 0.49430417 0.48493333 0.4042000 -0.08073333 5.460565e-01 1.219998e-11 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184319 E001 22.3466372 0.0011204141 7.233152e-01 8.171717e-01 22 50756948 50757326 379 + 1.380 1.360 -0.069
ENSG00000184319 E002 7.4280316 0.0257201401 9.953898e-01 1.000000e+00 22 50783120 50783253 134 + 0.926 0.941 0.055
ENSG00000184319 E003 5.3914633 0.0141636568 9.330848e-01 9.618254e-01 22 50783254 50783294 41 + 0.807 0.801 -0.025
ENSG00000184319 E004 0.0000000       22 50783740 50783744 5 +      
ENSG00000184319 E005 0.1451727 0.0431780371 4.637298e-01   22 50783745 50783754 10 + 0.126 0.000 -8.689
ENSG00000184319 E006 1.0255689 0.0126845056 4.772364e-01 6.158323e-01 22 50783755 50783763 9 + 0.224 0.353 0.890
ENSG00000184319 E007 1.1738620 0.0108647759 3.062580e-01 4.484211e-01 22 50783764 50783765 2 + 0.224 0.409 1.211
ENSG00000184319 E008 2.7550409 0.0062363753 3.097713e-01 4.521136e-01 22 50783766 50783768 3 + 0.481 0.648 0.762
ENSG00000184319 E009 5.2156735 0.0652734796 7.191337e-01 8.140545e-01 22 50783769 50783774 6 + 0.758 0.820 0.246
ENSG00000184319 E010 9.4101190 0.0020924991 6.619241e-01 7.702958e-01 22 50783775 50783780 6 + 0.991 1.042 0.188
ENSG00000184319 E011 10.1036140 0.0054893269 6.804103e-01 7.842968e-01 22 50783781 50783784 4 + 1.020 1.066 0.169
ENSG00000184319 E012 14.7198872 0.0472741601 9.347357e-01 9.628936e-01 22 50783785 50783788 4 + 1.200 1.194 -0.021
ENSG00000184319 E013 30.4302317 0.0010301895 8.006282e-01 8.729488e-01 22 50783789 50783796 8 + 1.488 1.509 0.073
ENSG00000184319 E014 48.3557589 0.0005118187 5.279110e-02 1.141250e-01 22 50783797 50783809 13 + 1.636 1.739 0.349
ENSG00000184319 E015 103.5413210 0.0002916527 2.448075e-01 3.798085e-01 22 50783810 50783864 55 + 1.999 2.044 0.153
ENSG00000184319 E016 19.9174486 0.0035108628 5.283774e-02 1.141985e-01 22 50783865 50783874 10 + 1.398 1.252 -0.508
ENSG00000184319 E017 65.7229549 0.0167408843 7.110200e-02 1.451656e-01 22 50783875 50783979 105 + 1.893 1.753 -0.470
ENSG00000184319 E018 77.5451698 0.0184754860 9.639947e-02 1.849626e-01 22 50783980 50784021 42 + 1.957 1.833 -0.419
ENSG00000184319 E019 14.1807701 0.0269533124 2.103778e-01 3.389904e-01 22 50784022 50784072 51 + 1.085 1.237 0.542
ENSG00000184319 E020 7.4177252 0.0023861985 5.485013e-01 6.783516e-01 22 50784073 50784330 258 + 0.960 0.897 -0.237
ENSG00000184319 E021 5.9597362 0.1209796860 2.358962e-01 3.694289e-01 22 50784331 50784424 94 + 0.960 0.725 -0.914
ENSG00000184319 E022 4.2852919 0.0043807883 4.854271e-01 6.233027e-01 22 50784625 50784686 62 + 0.674 0.778 0.427
ENSG00000184319 E023 261.1721127 0.0001805668 1.406082e-02 3.836292e-02 22 50785173 50785293 121 + 2.391 2.445 0.182
ENSG00000184319 E024 30.3809429 0.0078429960 5.114390e-02 1.112049e-01 22 50788750 50788798 49 + 1.409 1.552 0.491
ENSG00000184319 E025 3.5969072 0.0153183162 2.359923e-01 3.695306e-01 22 50788799 50788802 4 + 0.758 0.581 -0.750
ENSG00000184319 E026 3.5666165 0.0329196371 4.375957e-01 5.795273e-01 22 50788803 50788891 89 + 0.732 0.614 -0.498
ENSG00000184319 E027 12.8295827 0.0154307742 2.968290e-01 4.381012e-01 22 50788892 50788894 3 + 1.072 1.179 0.385
ENSG00000184319 E028 32.2984199 0.0135687252 2.177894e-02 5.521518e-02 22 50788895 50789354 460 + 1.409 1.589 0.617
ENSG00000184319 E029 0.8147197 0.0145072194 7.353524e-01 8.261349e-01 22 50791177 50791303 127 + 0.224 0.288 0.473
ENSG00000184319 E030 254.3447503 0.0168885322 3.454883e-01 4.895819e-01 22 50798655 50799247 593 + 2.368 2.433 0.215
ENSG00000184319 E031 43.6555393 0.0005321101 2.234097e-39 7.464602e-37 22 50799248 50801309 2062 + 1.923 1.169 -2.589
ENSG00000184319 E032 0.0000000       22 50801953 50801995 43 +