ENSG00000184307

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330212 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding protein_coding 3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.3410400 0.20601440 0.65720329 0.20601440 0.21695357 1.6269989 0.07440833 0.10120000 0.12276667 0.021566667 5.153022e-01 1.76805e-16 FALSE TRUE
ENST00000488129 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding processed_transcript 3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.4164789 0.70955187 0.00000000 0.13754585 0.00000000 -6.1690268 0.13099583 0.30313333 0.00000000 -0.303133333 1.768050e-16 1.76805e-16 FALSE FALSE
ENST00000491556 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding protein_coding 3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.2110624 0.03550232 0.45141557 0.03550232 0.18556377 3.3420547 0.04406250 0.01533333 0.08100000 0.065666667 1.770798e-01 1.76805e-16 FALSE FALSE
ENST00000638807 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding protein_coding 3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 1.2976239 0.11423759 2.46767668 0.11423759 0.13050448 4.3178142 0.30324167 0.05613333 0.45273333 0.396600000 3.079693e-02 1.76805e-16 FALSE TRUE
MSTRG.23479.12 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding   3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.2790002 0.06555355 0.46937782 0.01576820 0.11227430 2.6655917 0.06553333 0.02836667 0.08623333 0.057866667 1.481175e-01 1.76805e-16 FALSE TRUE
MSTRG.23479.2 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding   3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.2207794 0.00000000 0.05575867 0.00000000 0.05575867 2.7171811 0.05949167 0.00000000 0.01066667 0.010666667 9.506844e-01 1.76805e-16 TRUE TRUE
MSTRG.23479.4 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding   3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.1660390 0.42366402 0.00000000 0.16549970 0.00000000 -5.4385059 0.07017083 0.17973333 0.00000000 -0.179733333 6.947660e-06 1.76805e-16 TRUE TRUE
MSTRG.23479.8 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding   3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.4459423 0.34061152 0.71984248 0.34061152 0.36002816 1.0577117 0.11659167 0.13226667 0.12920000 -0.003066667 7.441374e-01 1.76805e-16 FALSE TRUE
MSTRG.23479.9 ENSG00000184307 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC23 protein_coding   3.868053 2.307955 5.456672 0.1558302 0.1542165 1.23781 0.2019621 0.22134532 0.24735389 0.12091573 0.14006045 0.1537056 0.06130417 0.10026667 0.04453333 -0.055733333 8.338995e-01 1.76805e-16 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184307 E001 1.5071731 0.0085764865 1.229250e-01 2.241237e-01 3 113947901 113947964 64 + 0.467 0.174 -1.971
ENSG00000184307 E002 1.3921893 0.0210358693 5.893332e-01 7.124050e-01 3 113947965 113947974 10 + 0.398 0.298 -0.607
ENSG00000184307 E003 1.8329042 0.0135608923 6.772251e-01 7.819966e-01 3 113947975 113947990 16 + 0.467 0.394 -0.386
ENSG00000184307 E004 2.2746633 0.0159138836 8.286729e-01 8.923615e-01 3 113947991 113948012 22 + 0.498 0.539 0.196
ENSG00000184307 E005 1.8370689 0.0081874752 4.263349e-01 5.691806e-01 3 113948013 113948016 4 + 0.399 0.539 0.712
ENSG00000184307 E006 3.3754751 0.0374355340 6.069039e-01 7.269654e-01 3 113948017 113948051 35 + 0.602 0.692 0.384
ENSG00000184307 E007 4.4815723 0.0092662559 6.648329e-01 7.726001e-01 3 113948052 113948064 13 + 0.706 0.773 0.271
ENSG00000184307 E008 3.8893420 0.0206356936 5.834054e-01 7.075327e-01 3 113948065 113948069 5 + 0.647 0.735 0.367
ENSG00000184307 E009 7.6158835 0.0450619989 7.395888e-01 8.292420e-01 3 113948070 113948186 117 + 0.940 0.893 -0.180
ENSG00000184307 E010 5.4938816 0.0031338050 2.658314e-01 4.039331e-01 3 113948187 113948190 4 + 0.846 0.694 -0.609
ENSG00000184307 E011 1.5595994 0.0087610344 1.228588e-01 2.240373e-01 3 113948507 113948685 179 + 0.467 0.174 -1.970
ENSG00000184307 E012 4.2222006 0.0053318187 1.613874e-01 2.768982e-01 3 113948686 113948734 49 + 0.758 0.540 -0.938
ENSG00000184307 E013 3.8922281 0.1140350261 4.296223e-01 5.723312e-01 3 113948735 113948768 34 + 0.725 0.541 -0.798
ENSG00000184307 E014 5.4850246 0.0041013547 1.346124e-01 2.405713e-01 3 113948769 113948793 25 + 0.859 0.648 -0.853
ENSG00000184307 E015 9.6133328 0.0253465420 1.559052e-01 2.696567e-01 3 113948794 113948819 26 + 1.062 0.870 -0.719
ENSG00000184307 E016 18.8424897 0.0018552300 1.315083e-02 3.625731e-02 3 113948820 113948963 144 + 1.339 1.125 -0.758
ENSG00000184307 E017 38.4554439 0.0006763215 6.075100e-05 3.351415e-04 3 113953700 113954088 389 + 1.647 1.401 -0.845
ENSG00000184307 E018 38.3853155 0.0005952409 8.507207e-04 3.440420e-03 3 113954089 113954410 322 + 1.634 1.433 -0.688
ENSG00000184307 E019 11.1092629 0.0031415119 8.039978e-02 1.601869e-01 3 113956339 113956347 9 + 1.115 0.924 -0.700
ENSG00000184307 E020 28.5094988 0.0012338073 1.242178e-02 3.455153e-02 3 113956348 113956506 159 + 1.501 1.327 -0.603
ENSG00000184307 E021 0.1515154 0.0424898643 1.000000e+00   3 113957574 113957851 278 + 0.085 0.000 -10.439
ENSG00000184307 E022 22.9831826 0.0009612389 6.335593e-01 7.482352e-01 3 113958363 113958453 91 + 1.368 1.337 -0.109
ENSG00000184307 E023 19.1442196 0.0097036531 2.459971e-01 3.812586e-01 3 113958454 113958538 85 + 1.317 1.211 -0.372
ENSG00000184307 E024 46.3015157 0.0005551126 1.631969e-05 1.032844e-04 3 113958539 113959520 982 + 1.721 1.479 -0.825
ENSG00000184307 E025 13.2025474 0.0383558598 5.259890e-01 6.592767e-01 3 113959521 113959600 80 + 1.155 1.076 -0.286
ENSG00000184307 E026 63.5039219 0.0005415533 9.642226e-02 1.849926e-01 3 113959601 113960719 1119 + 1.810 1.738 -0.242
ENSG00000184307 E027 48.3526534 0.0032434534 3.057490e-01 4.478924e-01 3 113960720 113961051 332 + 1.651 1.714 0.211
ENSG00000184307 E028 213.1538661 0.0004581746 3.074562e-26 3.736155e-24 3 113961052 113963373 2322 + 2.222 2.446 0.748
ENSG00000184307 E029 0.3634088 0.4760280813 1.211847e-01   3 113965170 113965401 232 + 0.000 0.300 11.005
ENSG00000184307 E030 1.6919979 0.0079824796 8.120027e-01 8.807190e-01 3 113978320 113978446 127 + 0.434 0.394 -0.217