ENSG00000184205

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375442 ENSG00000184205 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPYL2 protein_coding protein_coding 28.85481 29.01377 31.02502 2.312425 0.7587375 0.09666219 10.484024 10.782170 13.147436 0.5138825 0.2972958 0.2858934 0.3621750 0.3739333 0.4238333 0.0499000 2.874467e-01 4.610575e-07 FALSE TRUE
ENST00000463525 ENSG00000184205 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPYL2 protein_coding retained_intron 28.85481 29.01377 31.02502 2.312425 0.7587375 0.09666219 9.185452 5.082082 12.338679 1.2020497 0.2176343 1.2780292 0.3164333 0.1720000 0.3979667 0.2259667 7.641043e-04 4.610575e-07 FALSE TRUE
MSTRG.34285.5 ENSG00000184205 HEK293_OSMI2_2hA HEK293_TMG_2hB TSPYL2 protein_coding   28.85481 29.01377 31.02502 2.312425 0.7587375 0.09666219 6.553778 10.925564 3.402712 1.2800289 0.4040556 -1.6800370 0.2301833 0.3785667 0.1094333 -0.2691333 4.610575e-07 4.610575e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184205 E001 14.288780 0.0012340074 1.154814e-02 3.246129e-02 X 53082367 53082380 14 + 1.277 1.074 -0.723
ENSG00000184205 E002 85.403691 0.0096211736 8.161830e-02 1.620893e-01 X 53082381 53082666 286 + 1.973 1.892 -0.274
ENSG00000184205 E003 54.571340 0.0008114061 3.484107e-03 1.167885e-02 X 53082667 53082752 86 + 1.800 1.681 -0.402
ENSG00000184205 E004 136.101166 0.0002874255 5.636365e-06 3.964919e-05 X 53082753 53082992 240 + 2.192 2.077 -0.384
ENSG00000184205 E005 71.337995 0.0028542456 3.160903e-03 1.074046e-02 X 53082993 53082999 7 + 1.919 1.799 -0.403
ENSG00000184205 E006 120.963743 0.0014466788 1.500630e-02 4.050176e-02 X 53083000 53083103 104 + 2.117 2.052 -0.218
ENSG00000184205 E007 69.730629 0.0003433108 9.926971e-01 9.995296e-01 X 53083104 53083122 19 + 1.833 1.855 0.074
ENSG00000184205 E008 157.511102 0.0004475325 2.389386e-02 5.958665e-02 X 53083123 53083305 183 + 2.220 2.177 -0.142
ENSG00000184205 E009 29.867821 0.0006965042 6.539519e-02 1.357006e-01 X 53084532 53084544 13 + 1.534 1.439 -0.324
ENSG00000184205 E010 132.236324 0.0002581866 9.163604e-03 2.669194e-02 X 53084545 53084622 78 + 2.151 2.094 -0.191
ENSG00000184205 E011 26.063961 0.0007656839 4.350689e-04 1.909387e-03 X 53084623 53084698 76 + 1.534 1.318 -0.745
ENSG00000184205 E012 14.325514 0.0155178492 1.688464e-02 4.467707e-02 X 53084699 53084754 56 + 1.285 1.054 -0.822
ENSG00000184205 E013 138.938800 0.0003614084 2.207508e-02 5.583595e-02 X 53084755 53084866 112 + 2.164 2.117 -0.157
ENSG00000184205 E014 8.007458 0.0306303532 9.343995e-04 3.734661e-03 X 53084867 53084953 87 + 1.134 0.688 -1.701
ENSG00000184205 E015 168.273430 0.0003054407 3.127227e-02 7.443041e-02 X 53084954 53085099 146 + 2.241 2.204 -0.123
ENSG00000184205 E016 12.165446 0.0014864204 1.508150e-02 4.067098e-02 X 53085100 53085226 127 + 1.220 1.011 -0.753
ENSG00000184205 E017 170.467278 0.0002830816 3.672047e-01 5.115800e-01 X 53085227 53085321 95 + 2.228 2.226 -0.007
ENSG00000184205 E018 6.841483 0.0036467689 9.892240e-04 3.921602e-03 X 53085322 53085630 309 + 1.065 0.684 -1.472
ENSG00000184205 E019 843.416880 0.0002417162 3.625187e-02 8.406336e-02 X 53085631 53086310 680 + 2.894 2.942 0.158
ENSG00000184205 E020 14.936766 0.0013238099 8.225595e-01 8.881258e-01 X 53086311 53087775 1465 + 1.202 1.204 0.006
ENSG00000184205 E021 521.840532 0.0025434534 6.357699e-18 3.191434e-16 X 53087776 53088540 765 + 2.562 2.807 0.818