ENSG00000184164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328268 ENSG00000184164 HEK293_OSMI2_2hA HEK293_TMG_2hB CRELD2 protein_coding protein_coding 81.59057 100.5635 88.79793 1.9297 2.054536 -0.1794904 57.58179 51.13533 78.7076888 12.33527 1.5637377 0.6220854 0.6614458 0.5041000 0.886500000 0.3824000 0.001139494 2.009097e-06 FALSE TRUE
MSTRG.22355.3 ENSG00000184164 HEK293_OSMI2_2hA HEK293_TMG_2hB CRELD2 protein_coding   81.59057 100.5635 88.79793 1.9297 2.054536 -0.1794904 15.34273 41.39900 0.4421965 10.86391 0.4421965 -6.5168508 0.2259250 0.4161667 0.005033333 -0.4111333 0.001736230 2.009097e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184164 E001 4.1794929 4.774493e-02 3.094650e-01 4.517639e-01 22 49918167 49918346 180 + 0.600 0.765 0.696
ENSG00000184164 E002 3.8934140 1.352907e-02 9.756521e-02 1.867663e-01 22 49918347 49918430 84 + 0.510 0.766 1.111
ENSG00000184164 E003 0.0000000       22 49918634 49918634 1 +      
ENSG00000184164 E004 3.9788717 4.209846e-02 3.556074e-05 2.075503e-04 22 49918635 49918671 37 + 0.982 0.268 -3.330
ENSG00000184164 E005 6.0438303 1.212977e-02 4.011036e-06 2.916777e-05 22 49918672 49918674 3 + 1.112 0.476 -2.583
ENSG00000184164 E006 75.4268383 3.434107e-02 1.100583e-03 4.304873e-03 22 49918675 49918732 58 + 2.038 1.716 -1.087
ENSG00000184164 E007 81.4940423 3.216180e-02 9.215189e-04 3.690457e-03 22 49918733 49918758 26 + 2.068 1.753 -1.060
ENSG00000184164 E008 84.3616605 3.250832e-02 2.220648e-03 7.907507e-03 22 49918759 49918769 11 + 2.071 1.784 -0.964
ENSG00000184164 E009 330.7365091 3.619196e-03 4.362570e-06 3.146561e-05 22 49918770 49918898 129 + 2.600 2.437 -0.544
ENSG00000184164 E010 563.2823448 4.711876e-04 6.135143e-07 5.334516e-06 22 49919230 49919312 83 + 2.793 2.700 -0.308
ENSG00000184164 E011 757.0109212 7.563170e-04 1.758949e-01 2.958578e-01 22 49919730 49919840 111 + 2.884 2.856 -0.094
ENSG00000184164 E012 748.1195625 9.138286e-04 1.651817e-02 4.388183e-02 22 49920156 49920247 92 + 2.836 2.877 0.136
ENSG00000184164 E013 0.2934659 2.909593e-02 8.480306e-01   22 49921289 49921306 18 + 0.138 0.108 -0.393
ENSG00000184164 E014 0.7718584 1.582072e-02 4.650993e-01 6.048053e-01 22 49921307 49921473 167 + 0.326 0.195 -0.977
ENSG00000184164 E015 2.6121324 6.096417e-03 4.247965e-01 5.677349e-01 22 49921584 49921584 1 + 0.457 0.585 0.611
ENSG00000184164 E016 1002.2196932 9.293464e-05 2.232932e-01 3.543238e-01 22 49921585 49921761 177 + 2.983 2.992 0.032
ENSG00000184164 E017 5.1847314 6.862723e-03 3.804856e-02 8.744297e-02 22 49921871 49922293 423 + 0.927 0.645 -1.126
ENSG00000184164 E018 11.0783448 1.542792e-03 1.963602e-01 3.216727e-01 22 49922294 49922296 3 + 1.147 1.016 -0.475
ENSG00000184164 E019 27.7874382 5.559639e-03 1.379117e-03 5.238754e-03 22 49922297 49922443 147 + 1.578 1.338 -0.828
ENSG00000184164 E020 788.5758844 5.408557e-04 3.623535e-02 8.403360e-02 22 49922612 49922707 96 + 2.866 2.896 0.100
ENSG00000184164 E021 5.3531816 3.475848e-02 6.617381e-01 7.701621e-01 22 49923210 49923233 24 + 0.819 0.749 -0.278
ENSG00000184164 E022 741.0382682 5.204744e-04 1.799540e-04 8.777935e-04 22 49923234 49923317 84 + 2.822 2.880 0.193
ENSG00000184164 E023 112.4305022 3.164125e-04 1.924380e-01 3.168256e-01 22 49923318 49924359 1042 + 2.015 2.055 0.136
ENSG00000184164 E024 401.5845493 1.340231e-03 6.754621e-01 7.807460e-01 22 49924360 49924361 2 + 2.589 2.596 0.024
ENSG00000184164 E025 543.1000801 1.090167e-03 8.964206e-01 9.377733e-01 22 49924362 49924389 28 + 2.727 2.721 -0.020
ENSG00000184164 E026 826.8394421 5.916232e-04 8.377567e-01 8.985783e-01 22 49924390 49924455 66 + 2.907 2.907 -0.001
ENSG00000184164 E027 14.6036446 1.252719e-03 7.899569e-01 8.656408e-01 22 49924456 49924985 530 + 1.202 1.174 -0.098
ENSG00000184164 E028 19.0652619 1.173307e-03 5.481820e-01 6.780496e-01 22 49924986 49925416 431 + 1.259 1.302 0.153
ENSG00000184164 E029 1073.5095846 4.629920e-04 3.948600e-02 9.008174e-02 22 49925417 49925557 141 + 3.004 3.029 0.083
ENSG00000184164 E030 9.1831183 2.007642e-03 5.369013e-03 1.693284e-02 22 49925558 49926505 948 + 1.159 0.860 -1.101
ENSG00000184164 E031 761.3456974 2.004733e-03 1.496428e-03 5.624206e-03 22 49927255 49927540 286 + 2.825 2.898 0.245