ENSG00000184060

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330889 ENSG00000184060 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAP2 protein_coding protein_coding 3.294015 5.092463 2.413062 0.3500931 0.06617865 -1.074362 1.87691220 3.07236557 1.34510003 0.25493366 0.06760539 -1.1856386 0.56306667 0.604633333 0.55960000 -0.0450333333 0.8246580778 0.0006871689 FALSE  
ENST00000480980 ENSG00000184060 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAP2 protein_coding retained_intron 3.294015 5.092463 2.413062 0.3500931 0.06617865 -1.074362 0.16803631 0.16956782 0.08134030 0.02394681 0.04716685 -0.9752053 0.05543333 0.034100000 0.03326667 -0.0008333333 0.9532615786 0.0006871689    
ENST00000580525 ENSG00000184060 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAP2 protein_coding protein_coding 3.294015 5.092463 2.413062 0.3500931 0.06617865 -1.074362 0.07259338 0.39215645 0.00000000 0.08559593 0.00000000 -5.3296850 0.01741667 0.079900000 0.00000000 -0.0799000000 0.0006871689 0.0006871689 FALSE  
ENST00000580526 ENSG00000184060 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAP2 protein_coding nonsense_mediated_decay 3.294015 5.092463 2.413062 0.3500931 0.06617865 -1.074362 0.28686175 0.24264519 0.19573845 0.12398893 0.19573845 -0.2963013 0.09942500 0.051033333 0.07756667 0.0265333333 0.8117699341 0.0006871689 FALSE  
ENST00000581548 ENSG00000184060 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAP2 protein_coding protein_coding 3.294015 5.092463 2.413062 0.3500931 0.06617865 -1.074362 0.07583866 0.11526712 0.20121852 0.11526712 0.14330705 0.7537286 0.02154167 0.023900000 0.08406667 0.0601666667 0.5914515788 0.0006871689 FALSE  
ENST00000583688 ENSG00000184060 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAP2 protein_coding processed_transcript 3.294015 5.092463 2.413062 0.3500931 0.06617865 -1.074362 0.22380549 0.04174845 0.20759099 0.04174845 0.10391774 2.0720314 0.07961667 0.008666667 0.08623333 0.0775666667 0.3759300547 0.0006871689    
ENST00000584989 ENSG00000184060 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAP2 protein_coding protein_coding 3.294015 5.092463 2.413062 0.3500931 0.06617865 -1.074362 0.31862108 0.63575252 0.09130767 0.46375177 0.09130767 -2.6722380 0.08417083 0.114100000 0.03773333 -0.0763666667 0.7085051693 0.0006871689 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184060 E001 0.9514613 0.0637442904 0.007516463 0.02255546 17 30906344 30906644 301 + 0.557 0.081 -3.677
ENSG00000184060 E002 0.0000000       17 30921680 30921703 24 +      
ENSG00000184060 E003 1.3598223 0.0098184274 0.015907338 0.04252709 17 30921704 30921916 213 + 0.616 0.206 -2.365
ENSG00000184060 E004 1.1770843 0.0111653517 0.392384753 0.53633198 17 30921917 30921931 15 + 0.409 0.258 -0.948
ENSG00000184060 E005 1.1770843 0.0111653517 0.392384753 0.53633198 17 30921932 30921934 3 + 0.409 0.258 -0.948
ENSG00000184060 E006 1.8058463 0.0081327630 0.211747485 0.34054439 17 30921935 30921944 10 + 0.557 0.346 -1.100
ENSG00000184060 E007 2.1327234 0.0073753390 0.159083559 0.27389330 17 30921945 30921947 3 + 0.616 0.384 -1.141
ENSG00000184060 E008 10.9288475 0.0016758372 0.925228514 0.95693847 17 30921948 30922108 161 + 1.017 1.014 -0.009
ENSG00000184060 E009 18.8778479 0.0010715620 0.892961943 0.93559659 17 30922940 30923070 131 + 1.235 1.231 -0.013
ENSG00000184060 E010 0.9211812 0.0136968632 0.147408643 0.25817124 17 30926809 30926826 18 + 0.000 0.304 9.964
ENSG00000184060 E011 17.5742680 0.0011445758 0.899576103 0.93991819 17 30926827 30926918 92 + 1.208 1.205 -0.011
ENSG00000184060 E012 22.1509480 0.0009150775 0.574834016 0.70057306 17 30931889 30931968 80 + 1.330 1.294 -0.125
ENSG00000184060 E013 25.4401542 0.0008953312 0.630089603 0.74532839 17 30934185 30934297 113 + 1.380 1.352 -0.095
ENSG00000184060 E014 29.3983353 0.0007147477 0.513902894 0.64867717 17 30944907 30945027 121 + 1.380 1.434 0.188
ENSG00000184060 E015 13.7937263 0.0023828134 0.323213459 0.46653171 17 30945028 30945041 14 + 1.179 1.092 -0.312
ENSG00000184060 E016 13.9743840 0.0016934642 0.786919425 0.86356331 17 30945042 30945053 12 + 1.131 1.113 -0.066
ENSG00000184060 E017 25.4863412 0.0154946017 0.479480576 0.61785318 17 30949287 30949370 84 + 1.297 1.369 0.251
ENSG00000184060 E018 20.8479666 0.0042099834 0.957510192 0.97736044 17 30953288 30953350 63 + 1.261 1.272 0.039
ENSG00000184060 E019 0.0000000       17 30954240 30954253 14 +      
ENSG00000184060 E020 0.5546650 0.0206599484 0.821970757 0.88774810 17 30954254 30954477 224 + 0.182 0.148 -0.361
ENSG00000184060 E021 22.8465167 0.0008972654 0.997362856 1.00000000 17 30954478 30954555 78 + 1.308 1.316 0.027
ENSG00000184060 E022 33.1508052 0.0007144416 0.614600629 0.73300542 17 30956241 30956391 151 + 1.441 1.483 0.144
ENSG00000184060 E023 20.7298032 0.0010112702 0.944454741 0.96917432 17 30956392 30956469 78 + 1.273 1.275 0.009
ENSG00000184060 E024 1.7659906 0.0091644542 0.985613085 0.99503044 17 30956470 30956728 259 + 0.409 0.418 0.049
ENSG00000184060 E025 117.5981813 0.0098357904 0.431368700 0.57392529 17 30957835 30959322 1488 + 1.975 2.022 0.156