ENSG00000184058

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000475303 ENSG00000184058 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX1 protein_coding retained_intron 37.54529 48.01001 32.04375 3.364912 0.7303424 -0.5831425 4.394254 2.837922 4.843620 0.3561112 0.1888041 0.7691514 0.1314042 0.05863333 0.15126667 0.09263333 3.581217e-11 4.49289e-12   FALSE
ENST00000649276 ENSG00000184058 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX1 protein_coding protein_coding 37.54529 48.01001 32.04375 3.364912 0.7303424 -0.5831425 11.177179 9.779572 15.783712 3.2273827 0.6595423 0.6900327 0.2917083 0.19573333 0.49253333 0.29680000 1.648905e-02 4.49289e-12 FALSE TRUE
MSTRG.21641.10 ENSG00000184058 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX1 protein_coding   37.54529 48.01001 32.04375 3.364912 0.7303424 -0.5831425 3.617955 3.843734 3.063513 0.8837899 0.5685370 -0.3263683 0.0951500 0.07946667 0.09493333 0.01546667 8.070516e-01 4.49289e-12 FALSE FALSE
MSTRG.21641.13 ENSG00000184058 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX1 protein_coding   37.54529 48.01001 32.04375 3.364912 0.7303424 -0.5831425 3.427741 3.070624 3.577886 0.2865659 0.2039981 0.2199116 0.1020917 0.06550000 0.11186667 0.04636667 7.702922e-02 4.49289e-12 FALSE FALSE
MSTRG.21641.7 ENSG00000184058 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX1 protein_coding   37.54529 48.01001 32.04375 3.364912 0.7303424 -0.5831425 12.318604 25.266004 2.761611 0.8926115 0.4233929 -3.1889718 0.3085042 0.53293333 0.08640000 -0.44653333 4.492890e-12 4.49289e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184058 E001 0.0000000       22 19752538 19756702 4165 +      
ENSG00000184058 E002 0.0000000       22 19756703 19756745 43 +      
ENSG00000184058 E003 0.1451727 0.0435272403 2.761047e-01   22 19756746 19758781 2036 + 0.159 0.000 -9.984
ENSG00000184058 E004 0.0000000       22 19758782 19758988 207 +      
ENSG00000184058 E005 0.2214452 0.0374230196 8.409095e-01   22 19758989 19759557 569 + 0.000 0.094 9.870
ENSG00000184058 E006 0.3666179 0.0291213575 6.693989e-01 7.762228e-01 22 19759558 19759677 120 + 0.159 0.094 -0.875
ENSG00000184058 E007 0.6696487 0.0242040759 1.157806e-01 2.139199e-01 22 19760506 19760543 38 + 0.366 0.094 -2.461
ENSG00000184058 E008 38.2419892 0.0230747777 1.348201e-07 1.335910e-06 22 19760778 19760904 127 + 1.825 1.341 -1.652
ENSG00000184058 E009 147.6796743 0.0122050429 5.937255e-04 2.510703e-03 22 19760905 19761196 292 + 2.265 2.061 -0.684
ENSG00000184058 E010 193.1351262 0.0002753569 6.532196e-01 7.637575e-01 22 19761197 19761280 84 + 2.246 2.249 0.010
ENSG00000184058 E011 279.8568413 0.0001761676 7.400009e-04 3.042735e-03 22 19763241 19763342 102 + 2.362 2.429 0.225
ENSG00000184058 E012 13.3246440 0.0013371812 3.550864e-04 1.599877e-03 22 19763343 19763356 14 + 1.319 0.984 -1.200
ENSG00000184058 E013 53.4365769 0.0004526351 3.959355e-23 3.563363e-21 22 19763357 19763702 346 + 1.970 1.485 -1.643
ENSG00000184058 E014 21.5018368 0.0009192547 2.423495e-09 3.343947e-08 22 19764094 19764154 61 + 1.570 1.122 -1.563
ENSG00000184058 E015 496.3643490 0.0005205925 1.604327e-03 5.975207e-03 22 19764155 19764326 172 + 2.624 2.675 0.169
ENSG00000184058 E016 521.9705879 0.0006457579 4.182524e-01 5.615378e-01 22 19764958 19765078 121 + 2.677 2.684 0.024
ENSG00000184058 E017 339.7342858 0.0001858778 6.350852e-01 7.494487e-01 22 19765079 19765113 35 + 2.494 2.494 0.001
ENSG00000184058 E018 37.8804884 0.0134801308 5.237098e-02 1.133837e-01 22 19765114 19765167 54 + 1.650 1.494 -0.533
ENSG00000184058 E019 30.2278921 0.0089412176 2.429298e-03 8.549885e-03 22 19765701 19765757 57 + 1.614 1.375 -0.822
ENSG00000184058 E020 363.5206901 0.0001387474 9.432506e-01 9.684011e-01 22 19765758 19765825 68 + 2.529 2.521 -0.026
ENSG00000184058 E021 284.7330894 0.0049600247 9.040313e-01 9.429287e-01 22 19765902 19766002 101 + 2.422 2.417 -0.015
ENSG00000184058 E022 43.0304702 0.0152935703 3.584275e-03 1.196677e-02 22 19766003 19766327 325 + 1.756 1.519 -0.808
ENSG00000184058 E023 690.7093791 0.0004267026 2.076512e-09 2.898106e-08 22 19766389 19767334 946 + 2.741 2.827 0.287
ENSG00000184058 E024 0.8910940 0.1497789874 3.229889e-01 4.663396e-01 22 19773707 19773747 41 + 0.367 0.173 -1.436
ENSG00000184058 E025 2.6528287 0.0058353371 5.276489e-02 1.140735e-01 22 19779220 19779546 327 + 0.275 0.615 1.822
ENSG00000184058 E026 0.0000000       22 19782913 19783032 120 +      
ENSG00000184058 E027 0.1472490 0.0428824625 2.763533e-01   22 19783033 19783221 189 + 0.159 0.000 -11.781
ENSG00000184058 E028 0.2987644 0.0268983968 8.444045e-02   22 19783314 19783593 280 + 0.275 0.000 -13.050