ENSG00000184009

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000573283 ENSG00000184009 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTG1 protein_coding protein_coding 2885.818 5905.72 1544.884 327.7854 20.1405 -1.934608 2376.1293 4626.451 1380.83032 402.24050 7.719194 -1.744362 0.8513750 0.7808333 0.89423333 0.1134000 0.02022627 1.01427e-24 FALSE TRUE
ENST00000576209 ENSG00000184009 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTG1 protein_coding retained_intron 2885.818 5905.72 1544.884 327.7854 20.1405 -1.934608 386.1461 1050.856 70.77473 97.48326 29.488826 -3.891997 0.1009792 0.1801667 0.04533333 -0.1348333 0.07438035 1.01427e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184009 E001 1.217869e+00 0.0103953542 5.243051e-01 6.578687e-01 17 81509413 81509912 500 - 0.366 0.255 -0.728
ENSG00000184009 E002 5.429072e+00 0.0374486169 4.365826e-01 5.786484e-01 17 81509913 81509970 58 - 0.563 0.725 0.701
ENSG00000184009 E003 4.311603e+02 0.0233810896 5.022965e-14 1.491046e-12 17 81509971 81509975 5 - 1.884 2.570 2.294
ENSG00000184009 E004 4.717493e+02 0.0162797156 5.578586e-14 1.644129e-12 17 81509976 81509976 1 - 2.027 2.604 1.929
ENSG00000184009 E005 5.515118e+02 0.0114644400 1.904836e-10 3.203706e-09 17 81509977 81509977 1 - 2.248 2.662 1.380
ENSG00000184009 E006 2.935013e+03 0.0030276806 1.569985e-16 6.603663e-15 17 81509978 81509988 11 - 3.106 3.375 0.894
ENSG00000184009 E007 3.009809e+03 0.0028882340 1.317885e-18 7.149752e-17 17 81509989 81509991 3 - 3.107 3.387 0.930
ENSG00000184009 E008 3.710318e+03 0.0017905602 4.533937e-30 7.689712e-28 17 81509992 81510004 13 - 3.189 3.478 0.962
ENSG00000184009 E009 3.829362e+03 0.0018287315 2.045914e-30 3.542891e-28 17 81510005 81510007 3 - 3.200 3.492 0.973
ENSG00000184009 E010 4.468331e+04 0.0010327493 3.677880e-22 2.975078e-20 17 81510008 81510287 280 - 4.376 4.546 0.564
ENSG00000184009 E011 3.045359e+04 0.0005762310 3.448016e-12 7.751469e-11 17 81510288 81510329 42 - 4.265 4.372 0.353
ENSG00000184009 E012 3.403842e+04 0.0007868310 1.339163e-11 2.732368e-10 17 81510330 81510395 66 - 4.305 4.421 0.385
ENSG00000184009 E013 3.449012e+04 0.0008852118 2.734547e-08 3.102849e-07 17 81510396 81510478 83 - 4.322 4.425 0.345
ENSG00000184009 E014 5.026986e+04 0.0004399857 3.240147e-09 4.368318e-08 17 81510479 81510689 211 - 4.503 4.586 0.275
ENSG00000184009 E015 3.722849e+04 0.0004822414 8.896298e-02 1.735427e-01 17 81510690 81510833 144 - 4.436 4.444 0.027
ENSG00000184009 E016 3.554364e+04 0.0005034244 4.573966e-05 2.601784e-04 17 81510927 81511108 182 - 4.437 4.420 -0.057
ENSG00000184009 E017 1.212826e+02 0.0045360973 7.189100e-11 1.299326e-09 17 81511109 81511187 79 - 2.188 1.894 -0.986
ENSG00000184009 E018 5.551024e+04 0.0005228233 2.771130e-15 9.903459e-14 17 81511188 81511578 391 - 4.661 4.607 -0.179
ENSG00000184009 E019 1.820815e+04 0.0002742388 4.830617e-17 2.156837e-15 17 81511579 81511626 48 - 4.170 4.124 -0.153
ENSG00000184009 E020 1.361451e+02 0.0003809384 7.194130e-66 9.086042e-63 17 81511627 81511762 136 - 2.400 1.861 -1.805
ENSG00000184009 E021 6.745484e+01 0.0003594103 3.424065e-69 5.028518e-66 17 81511763 81511803 41 - 2.209 1.462 -2.524
ENSG00000184009 E022 6.690432e+01 0.0046117146 1.151947e-53 8.764373e-51 17 81511804 81511902 99 - 2.235 1.427 -2.731
ENSG00000184009 E023 1.474047e+04 0.0001486370 1.257609e-36 3.467980e-34 17 81511903 81511926 24 - 4.091 4.030 -0.204
ENSG00000184009 E024 3.189852e+04 0.0003664966 9.280551e-25 9.921967e-23 17 81511927 81512115 189 - 4.432 4.364 -0.227
ENSG00000184009 E025 1.512725e+04 0.0004505006 5.613342e-16 2.192459e-14 17 81512116 81512142 27 - 4.102 4.041 -0.204
ENSG00000184009 E026 9.901861e+01 0.0008974517 5.543657e-05 3.088455e-04 17 81512143 81512150 8 - 1.999 1.844 -0.521
ENSG00000184009 E027 1.382593e+04 0.0003336161 1.126494e-17 5.488962e-16 17 81512232 81512247 16 - 4.059 4.003 -0.186
ENSG00000184009 E028 2.307092e+04 0.0015213736 1.711675e-06 1.351470e-05 17 81512248 81512360 113 - 4.287 4.224 -0.208
ENSG00000184009 E029 6.231764e+01 0.0003746363 1.042455e-16 4.473158e-15 17 81512361 81512463 103 - 1.966 1.581 -1.301
ENSG00000184009 E030 2.018693e+01 0.0010341289 1.525173e-19 9.263848e-18 17 81512464 81512600 137 - 1.669 0.991 -2.377
ENSG00000184009 E031 4.606251e+01 0.0018841815 1.217735e-06 9.929248e-06 17 81512601 81512605 5 - 1.758 1.482 -0.941
ENSG00000184009 E032 5.121858e+01 0.0080566932 9.706739e-06 6.473449e-05 17 81512606 81512614 9 - 1.810 1.526 -0.963
ENSG00000184009 E033 2.522434e+02 0.0166327769 3.287024e-05 1.936483e-04 17 81512615 81512733 119 - 2.473 2.222 -0.841
ENSG00000184009 E034 1.353940e+04 0.0030182065 2.513652e-03 8.805380e-03 17 81512734 81512794 61 - 4.048 3.994 -0.177
ENSG00000184009 E035 7.199145e+01 0.0012315518 6.100496e-02 1.283250e-01 17 81512795 81512876 82 - 1.797 1.719 -0.261
ENSG00000184009 E036 3.729606e-01 0.0318123380 2.848384e-01 4.251135e-01 17 81513627 81513672 46 - 0.221 0.065 -2.048
ENSG00000184009 E037 3.174174e+00 0.0050930630 4.885657e-03 1.561200e-02 17 81513673 81514113 441 - 0.843 0.415 -1.898
ENSG00000184009 E038 7.753515e+00 0.0022247858 8.933733e-01 9.358495e-01 17 81514547 81514610 64 - 0.799 0.840 0.159
ENSG00000184009 E039 4.751703e-01 0.0205535697 5.194510e-01 6.535547e-01 17 81514611 81514720 110 - 0.221 0.120 -1.053
ENSG00000184009 E040 8.804848e-01 0.2121324683 7.870953e-02 1.574448e-01 17 81523642 81523847 206 - 0.475 0.123 -2.592