ENSG00000184007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457805 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding protein_coding 157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 28.428967 14.316718 38.461348 5.2654007 1.692377 1.4250763 0.15851250 0.1266667 0.181400000 0.054733333 4.984812e-01 4.40616e-26 FALSE TRUE
ENST00000528840 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding processed_transcript 157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 10.633684 2.680141 36.311360 1.5914807 2.591036 3.7550646 0.05915000 0.0254000 0.171500000 0.146100000 2.076924e-01 4.40616e-26   FALSE
ENST00000529477 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding processed_transcript 157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 15.283671 6.883107 0.000000 6.8831070 0.000000 -9.4290106 0.07765833 0.0611000 0.000000000 -0.061100000 4.129154e-01 4.40616e-26   FALSE
ENST00000602683 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding protein_coding 157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 19.288976 14.251223 25.492703 0.9694386 2.366986 0.8385525 0.12518750 0.1278667 0.119700000 -0.008166667 8.697314e-01 4.40616e-26 FALSE TRUE
ENST00000602725 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding protein_coding 157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 31.735706 35.776612 21.967257 5.8733972 5.411649 -0.7034086 0.22407917 0.3158333 0.102500000 -0.213333333 8.694643e-04 4.40616e-26 FALSE TRUE
ENST00000647444 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding protein_coding 157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 29.954887 12.374104 68.484628 1.3120995 3.406661 2.4675014 0.18012917 0.1115000 0.323000000 0.211500000 5.641632e-08 4.40616e-26 FALSE TRUE
MSTRG.747.5 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding   157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 9.615138 22.312573 1.462843 6.0803068 1.462843 -3.9218282 0.09719583 0.1985333 0.006766667 -0.191766667 1.541685e-02 4.40616e-26 FALSE FALSE
MSTRG.747.7 ENSG00000184007 HEK293_OSMI2_2hA HEK293_TMG_2hB PTP4A2 protein_coding   157.2186 112.2686 212.4416 8.038853 4.24825 0.9200517 4.650699 0.000000 13.221456 0.0000000 2.404443 10.3697562 0.02626250 0.0000000 0.061833333 0.061833333 4.406160e-26 4.40616e-26 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000184007 E001 3126.1794619 2.037937e-03 5.449344e-01 6.753377e-01 1 31906421 31908262 1842 - 3.491 3.496 0.016
ENSG00000184007 E002 629.9662555 1.298724e-04 2.840988e-17 1.307939e-15 1 31908263 31908533 271 - 2.854 2.722 -0.439
ENSG00000184007 E003 295.0929681 1.515583e-04 2.437979e-08 2.794456e-07 1 31908534 31908585 52 - 2.523 2.399 -0.412
ENSG00000184007 E004 330.8148706 1.331869e-04 9.637383e-07 8.021851e-06 1 31908586 31908652 67 - 2.564 2.461 -0.342
ENSG00000184007 E005 188.5822402 2.037658e-04 6.879002e-05 3.742672e-04 1 31908653 31908657 5 - 2.325 2.215 -0.367
ENSG00000184007 E006 520.5782455 1.193365e-04 3.673244e-03 1.222051e-02 1 31908658 31908707 50 - 2.739 2.688 -0.169
ENSG00000184007 E007 1036.9915702 9.608688e-05 5.914650e-02 1.251676e-01 1 31908708 31908838 131 - 3.008 3.027 0.061
ENSG00000184007 E008 1269.4055494 1.213772e-03 8.947571e-04 3.595483e-03 1 31908839 31908960 122 - 3.078 3.131 0.178
ENSG00000184007 E009 764.3585047 4.958273e-04 2.254680e-07 2.140055e-06 1 31910038 31910068 31 - 2.847 2.926 0.261
ENSG00000184007 E010 767.0550257 9.618406e-04 3.797195e-03 1.257415e-02 1 31910069 31910112 44 - 2.862 2.911 0.162
ENSG00000184007 E011 5.7383538 1.817527e-02 5.613671e-01 6.892016e-01 1 31910113 31911280 1168 - 0.861 0.769 -0.360
ENSG00000184007 E012 1292.6618156 7.594205e-05 9.704083e-07 8.072404e-06 1 31911696 31911826 131 - 3.092 3.138 0.156
ENSG00000184007 E013 1.0360657 2.040092e-02 8.548730e-01 9.102275e-01 1 31912981 31913023 43 - 0.310 0.345 0.216
ENSG00000184007 E014 1.7905103 9.741761e-02 3.817175e-03 1.262883e-02 1 31913787 31913843 57 - 0.617 0.000 -12.682
ENSG00000184007 E015 3.8716099 8.979558e-02 9.869539e-01 9.959012e-01 1 31915540 31915894 355 - 0.691 0.698 0.028
ENSG00000184007 E016 713.0173867 3.284344e-04 5.107484e-01 6.459133e-01 1 31915895 31915987 93 - 2.852 2.857 0.017
ENSG00000184007 E017 634.1630394 9.350249e-04 2.106734e-01 3.393398e-01 1 31918970 31918999 30 - 2.795 2.814 0.065
ENSG00000184007 E018 936.6157831 8.305035e-05 2.459754e-05 1.494813e-04 1 31919000 31919093 94 - 2.952 2.999 0.157
ENSG00000184007 E019 601.9692145 1.192783e-04 4.090170e-11 7.697134e-10 1 31919094 31919129 36 - 2.738 2.834 0.320
ENSG00000184007 E020 654.8297906 2.932424e-04 4.656053e-06 3.338160e-05 1 31919130 31919228 99 - 2.786 2.854 0.226
ENSG00000184007 E021 327.6251740 2.572656e-03 1.059876e-01 1.995949e-01 1 31919229 31919243 15 - 2.497 2.539 0.142
ENSG00000184007 E022 291.2583258 3.202672e-03 1.119988e-01 2.084820e-01 1 31919244 31919246 3 - 2.445 2.488 0.145
ENSG00000184007 E023 286.3917768 1.667824e-03 2.583649e-02 6.360233e-02 1 31919247 31919259 13 - 2.432 2.488 0.185
ENSG00000184007 E024 836.8042360 4.693291e-04 2.714801e-01 4.102500e-01 1 31919260 31919423 164 - 2.918 2.928 0.035
ENSG00000184007 E025 881.2501928 3.888556e-04 5.008216e-02 1.093065e-01 1 31919424 31919562 139 - 2.960 2.925 -0.118
ENSG00000184007 E026 368.0027933 6.850330e-04 3.717088e-04 1.664951e-03 1 31919563 31919568 6 - 2.602 2.516 -0.286
ENSG00000184007 E027 482.5743168 8.668327e-04 2.158424e-05 1.327706e-04 1 31919569 31919658 90 - 2.724 2.625 -0.329
ENSG00000184007 E028 0.0000000       1 31924018 31924165 148 -      
ENSG00000184007 E029 1.2586423 2.214838e-01 4.302636e-01 5.728995e-01 1 31930039 31930334 296 - 0.251 0.426 1.090
ENSG00000184007 E030 2.8784186 8.705244e-02 6.660933e-01 7.736127e-01 1 31930933 31931142 210 - 0.558 0.626 0.308
ENSG00000184007 E031 0.0000000       1 31932672 31932700 29 -      
ENSG00000184007 E032 0.7458221 2.357696e-02 3.708188e-01 5.152295e-01 1 31935589 31935659 71 - 0.311 0.148 -1.366
ENSG00000184007 E033 0.1472490 4.489881e-02 7.597163e-01   1 31937755 31937777 23 - 0.101 0.000 -9.091
ENSG00000184007 E034 1.3714636 1.013998e-02 2.889650e-01 4.296274e-01 1 31937778 31937841 64 - 0.451 0.258 -1.172
ENSG00000184007 E035 1.3015312 1.221478e-02 5.359987e-01 6.677911e-01 1 31937842 31937986 145 - 0.311 0.419 0.635
ENSG00000184007 E036 291.3628903 2.464633e-03 1.079540e-03 4.233577e-03 1 31937987 31938059 73 - 2.511 2.398 -0.377
ENSG00000184007 E037 162.3165756 6.669602e-03 7.579368e-15 2.541396e-13 1 31938060 31938118 59 - 2.347 1.937 -1.371
ENSG00000184007 E038 214.1931195 3.864521e-02 6.262036e-11 1.141794e-09 1 31938119 31938262 144 - 2.516 1.815 -2.349
ENSG00000184007 E039 149.0862878 5.697882e-02 1.114617e-08 1.362153e-07 1 31938263 31938368 106 - 2.365 1.623 -2.495
ENSG00000184007 E040 0.0000000       1 31942529 31942576 48 -      
ENSG00000184007 E041 0.0000000       1 31944593 31944856 264 -