ENSG00000183955

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402868 ENSG00000183955 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5A protein_coding protein_coding 51.23124 45.83684 72.95417 2.557449 1.742669 0.670366 10.663601 8.195250 12.992812 0.8669373 1.9676897 0.6642044 0.21353333 0.18173333 0.1772667 -0.004466667 1.000000e+00 2.432237e-28 FALSE TRUE
ENST00000437519 ENSG00000183955 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5A protein_coding nonsense_mediated_decay 51.23124 45.83684 72.95417 2.557449 1.742669 0.670366 22.301129 30.496249 23.746309 3.3396855 1.5623726 -0.3607941 0.45035833 0.66206667 0.3263667 -0.335700000 1.884488e-06 2.432237e-28 FALSE TRUE
ENST00000478781 ENSG00000183955 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5A protein_coding processed_transcript 51.23124 45.83684 72.95417 2.557449 1.742669 0.670366 3.388512 0.000000 8.632522 0.0000000 1.6270248 9.7553086 0.05637083 0.00000000 0.1175000 0.117500000 8.852451e-24 2.432237e-28 FALSE FALSE
ENST00000485469 ENSG00000183955 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5A protein_coding processed_transcript 51.23124 45.83684 72.95417 2.557449 1.742669 0.670366 8.974115 1.918101 20.855496 1.2366771 0.3831757 3.4358669 0.15614583 0.04083333 0.2864333 0.245600000 1.306384e-01 2.432237e-28 FALSE FALSE
ENST00000537270 ENSG00000183955 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5A protein_coding processed_transcript 51.23124 45.83684 72.95417 2.557449 1.742669 0.670366 2.322686 2.243672 1.916784 0.2591381 0.3064351 -0.2260825 0.05287500 0.04946667 0.0263000 -0.023166667 1.064166e-01 2.432237e-28   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183955 E001 8.027539 0.0361155170 2.929961e-02 7.058567e-02 12 123384132 123384165 34 + 1.059 0.811 -0.935
ENSG00000183955 E002 15.549662 0.0022123509 1.853268e-01 3.079034e-01 12 123384166 123384172 7 + 1.238 1.202 -0.127
ENSG00000183955 E003 33.799520 0.0007280118 1.343211e-03 5.120376e-03 12 123384173 123384208 36 + 1.599 1.489 -0.375
ENSG00000183955 E004 12.825900 0.0013728822 7.170737e-01 8.125723e-01 12 123388442 123388757 316 + 1.081 1.192 0.397
ENSG00000183955 E005 1.588642 0.0099821938 2.249442e-01 3.563544e-01 12 123388900 123388950 51 + 0.482 0.321 -0.899
ENSG00000183955 E006 6.204306 0.0037647529 7.905397e-07 6.712324e-06 12 123388951 123389008 58 + 1.060 0.450 -2.525
ENSG00000183955 E007 36.712305 0.0105079262 8.189074e-12 1.728574e-10 12 123389009 123389182 174 + 1.748 1.275 -1.621
ENSG00000183955 E008 3.179485 0.0416476235 9.166136e-01 9.513019e-01 12 123389271 123389432 162 + 0.592 0.633 0.178
ENSG00000183955 E009 19.304242 0.0252891839 2.075402e-02 5.306915e-02 12 123389433 123389436 4 + 1.389 1.203 -0.653
ENSG00000183955 E010 28.309622 0.0011411997 3.393267e-06 2.510601e-05 12 123389437 123389482 46 + 1.562 1.330 -0.799
ENSG00000183955 E011 55.069122 0.0133607893 7.472965e-03 2.244484e-02 12 123389483 123389554 72 + 1.801 1.679 -0.412
ENSG00000183955 E012 1.033977 0.0490794980 6.336279e-02 1.322932e-01 12 123390042 123390150 109 + 0.439 0.134 -2.266
ENSG00000183955 E013 193.041516 0.0005017201 2.672047e-13 7.151897e-12 12 123390630 123390710 81 + 2.342 2.227 -0.383
ENSG00000183955 E014 275.099098 0.0024172201 5.189036e-07 4.575292e-06 12 123390711 123390786 76 + 2.478 2.400 -0.259
ENSG00000183955 E015 1.804802 0.0117997214 8.110616e-01 8.801564e-01 12 123390787 123391304 518 + 0.439 0.450 0.061
ENSG00000183955 E016 1.479055 0.1649809999 2.217640e-01 3.524984e-01 12 123391380 123391430 51 + 0.199 0.510 1.940
ENSG00000183955 E017 541.037375 0.0018151266 1.498712e-06 1.198811e-05 12 123395047 123395266 220 + 2.752 2.717 -0.117
ENSG00000183955 E018 422.437375 0.0006773048 7.560895e-09 9.528297e-08 12 123396345 123396432 88 + 2.645 2.610 -0.116
ENSG00000183955 E019 343.734585 0.0001553085 6.279054e-04 2.635485e-03 12 123403573 123403632 60 + 2.531 2.550 0.062
ENSG00000183955 E020 425.019928 0.0002614854 4.606091e-02 1.021454e-01 12 123404884 123405074 191 + 2.609 2.657 0.161
ENSG00000183955 E021 1960.220489 0.0032131497 3.127343e-18 1.620530e-16 12 123407493 123409638 2146 + 3.165 3.395 0.763