ENSG00000183856

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361170 ENSG00000183856 HEK293_OSMI2_2hA HEK293_TMG_2hB IQGAP3 protein_coding protein_coding 14.275 13.011 11.4874 0.8087646 0.2727891 -0.1795324 11.679996 11.7577813 8.235213 0.6614970 0.39528560 -0.5132136 0.8172708 0.90446667 0.7162667 -0.1882000 6.553570e-08 5.447229e-09 FALSE TRUE
ENST00000476565 ENSG00000183856 HEK293_OSMI2_2hA HEK293_TMG_2hB IQGAP3 protein_coding processed_transcript 14.275 13.011 11.4874 0.8087646 0.2727891 -0.1795324 1.101068 0.2886283 1.582684 0.1049518 0.08369455 2.4150375 0.0720625 0.02173333 0.1376667 0.1159333 5.447229e-09 5.447229e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183856 E001 5.948008 0.1130687345 4.074858e-03 1.335357e-02 1 156525405 156525406 2 - 0.332 0.979 2.891
ENSG00000183856 E002 16.145456 0.1123691894 6.620553e-03 2.024084e-02 1 156525407 156525419 13 - 0.777 1.367 2.160
ENSG00000183856 E003 40.551131 0.0516492803 2.119858e-05 1.306698e-04 1 156525420 156525442 23 - 1.135 1.753 2.136
ENSG00000183856 E004 42.690079 0.0512050390 8.322101e-06 5.631307e-05 1 156525443 156525448 6 - 1.135 1.777 2.219
ENSG00000183856 E005 117.381143 0.0294680856 3.404791e-08 3.795273e-07 1 156525449 156525552 104 - 1.642 2.197 1.865
ENSG00000183856 E006 423.522221 0.0075199307 5.226684e-11 9.671611e-10 1 156525553 156526222 670 - 2.387 2.708 1.068
ENSG00000183856 E007 92.333679 0.0019456888 1.630422e-06 1.292835e-05 1 156526223 156526261 39 - 1.789 2.032 0.817
ENSG00000183856 E008 197.752295 0.0002174595 2.506063e-10 4.125889e-09 1 156526262 156526521 260 - 2.146 2.346 0.668
ENSG00000183856 E009 114.643922 0.0002775478 6.161037e-02 1.293328e-01 1 156526522 156526599 78 - 1.984 2.076 0.311
ENSG00000183856 E010 127.516711 0.0002852989 1.521590e-03 5.706776e-03 1 156527952 156528060 109 - 2.002 2.136 0.448
ENSG00000183856 E011 108.476865 0.0068327837 1.338382e-02 3.680969e-02 1 156528509 156528607 99 - 1.915 2.076 0.541
ENSG00000183856 E012 50.981958 0.0013876506 1.952690e-01 3.203118e-01 1 156528608 156528610 3 - 1.634 1.732 0.330
ENSG00000183856 E013 143.356942 0.0003181319 2.171748e-01 3.469855e-01 1 156528916 156529082 167 - 2.098 2.165 0.223
ENSG00000183856 E014 160.245377 0.0002377348 3.112983e-01 4.537446e-01 1 156530105 156530317 213 - 2.153 2.211 0.193
ENSG00000183856 E015 105.354685 0.0004006238 2.597719e-01 3.972252e-01 1 156531160 156531247 88 - 1.966 2.035 0.232
ENSG00000183856 E016 120.968455 0.0002820369 7.525433e-01 8.387047e-01 1 156532980 156533106 127 - 2.059 2.077 0.060
ENSG00000183856 E017 92.837034 0.0026262525 9.389272e-01 9.656519e-01 1 156533773 156533875 103 - 1.942 1.968 0.087
ENSG00000183856 E018 85.387512 0.0004031870 6.571059e-01 7.665346e-01 1 156534009 156534141 133 - 1.887 1.933 0.154
ENSG00000183856 E019 95.726944 0.0039755202 4.758979e-01 6.145742e-01 1 156534501 156534733 233 - 1.929 1.992 0.213
ENSG00000183856 E020 72.360565 0.0027176071 1.268329e-01 2.297384e-01 1 156535163 156535247 85 - 1.879 1.834 -0.150
ENSG00000183856 E021 8.872190 0.0018896069 8.424645e-10 1.265480e-08 1 156536831 156537175 345 - 1.270 0.607 -2.531
ENSG00000183856 E022 2.886012 0.0127273688 1.532728e-05 9.760515e-05 1 156537176 156537180 5 - 0.875 0.191 -3.555
ENSG00000183856 E023 99.004541 0.0002860010 4.277521e-04 1.881067e-03 1 156537181 156537321 141 - 2.043 1.945 -0.328
ENSG00000183856 E024 123.105104 0.0002683100 2.224673e-04 1.059764e-03 1 156538809 156539033 225 - 2.131 2.041 -0.304
ENSG00000183856 E025 4.588069 0.0558615018 9.487484e-01 9.718799e-01 1 156539034 156539373 340 - 0.717 0.755 0.155
ENSG00000183856 E026 108.078290 0.0008991081 7.630656e-03 2.284927e-02 1 156539374 156539537 164 - 2.059 1.990 -0.232
ENSG00000183856 E027 98.761964 0.0004717836 2.812673e-01 4.211573e-01 1 156539838 156539990 153 - 1.985 1.974 -0.039
ENSG00000183856 E028 110.165972 0.0009322622 9.687778e-02 1.857198e-01 1 156540708 156540916 209 - 2.048 2.015 -0.109
ENSG00000183856 E029 63.128484 0.0004176630 1.417250e-01 2.503974e-01 1 156543981 156544050 70 - 1.812 1.774 -0.130
ENSG00000183856 E030 57.395499 0.0005995803 1.267746e-02 3.515121e-02 1 156544152 156544223 72 - 1.799 1.709 -0.306
ENSG00000183856 E031 62.088871 0.0058739530 4.203446e-04 1.852361e-03 1 156544389 156544472 84 - 1.879 1.706 -0.584
ENSG00000183856 E032 76.627704 0.0003507551 9.151721e-13 2.261926e-11 1 156548073 156548243 171 - 2.017 1.757 -0.873
ENSG00000183856 E033 80.931596 0.0063267929 3.658077e-04 1.641936e-03 1 156548348 156548484 137 - 1.992 1.829 -0.549
ENSG00000183856 E034 28.240435 0.0024429817 5.135144e-04 2.210040e-03 1 156548485 156548487 3 - 1.568 1.360 -0.717
ENSG00000183856 E035 80.389947 0.0031543337 6.939822e-04 2.876993e-03 1 156548581 156548748 168 - 1.971 1.841 -0.440
ENSG00000183856 E036 61.352420 0.0003935722 2.592053e-03 9.041568e-03 1 156550261 156550351 91 - 1.842 1.734 -0.366
ENSG00000183856 E037 64.351686 0.0095765117 1.895687e-02 4.923801e-02 1 156551705 156551868 164 - 1.866 1.747 -0.401
ENSG00000183856 E038 52.779051 0.0030751333 9.518205e-02 1.831492e-01 1 156551974 156552095 122 - 1.749 1.686 -0.214
ENSG00000183856 E039 42.205868 0.0125207095 2.192886e-01 3.495198e-01 1 156554235 156554392 158 - 1.657 1.596 -0.207
ENSG00000183856 E040 53.017779 0.0339917979 6.613097e-01 7.697889e-01 1 156556533 156556693 161 - 1.727 1.712 -0.050
ENSG00000183856 E041 51.807321 0.0119023620 3.768012e-02 8.673090e-02 1 156560934 156561021 88 - 1.772 1.657 -0.390
ENSG00000183856 E042 80.307554 0.0048621479 9.804428e-04 3.892737e-03 1 156561838 156562001 164 - 1.973 1.834 -0.467
ENSG00000183856 E043 63.516609 0.0004869063 1.235465e-05 8.035675e-05 1 156562587 156562665 79 - 1.887 1.720 -0.564
ENSG00000183856 E044 72.088087 0.0093031967 3.513113e-06 2.590389e-05 1 156563134 156563312 179 - 1.987 1.731 -0.862
ENSG00000183856 E045 51.061348 0.0064072021 4.593663e-05 2.611890e-04 1 156563553 156563666 114 - 1.825 1.602 -0.755
ENSG00000183856 E046 43.795144 0.0233430450 2.084795e-02 5.326691e-02 1 156563757 156563824 68 - 1.742 1.556 -0.631
ENSG00000183856 E047 49.814893 0.0154207109 3.559969e-03 1.189736e-02 1 156564615 156564691 77 - 1.802 1.603 -0.675
ENSG00000183856 E048 56.001533 0.0083045163 1.387360e-03 5.265366e-03 1 156566027 156566104 78 - 1.840 1.663 -0.598
ENSG00000183856 E049 75.761012 0.0034936300 9.051375e-04 3.632111e-03 1 156566390 156566546 157 - 1.944 1.810 -0.452
ENSG00000183856 E050 51.662124 0.0075123722 1.702860e-02 4.499828e-02 1 156569376 156569463 88 - 1.772 1.650 -0.413
ENSG00000183856 E051 40.967628 0.0062697092 2.082946e-02 5.323115e-02 1 156572493 156572604 112 - 1.675 1.551 -0.421