ENSG00000183826

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314100 ENSG00000183826 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD9 protein_coding protein_coding 2.849714 3.047147 3.2572 0.2638231 0.2800944 0.09586905 0.3502571 1.0219347 0.0000000 0.56857156 0.00000000 -6.6892078 0.1217875 0.35156667 0.00000000 -0.35156667 0.1661851243 1.00386e-05 FALSE TRUE
ENST00000403056 ENSG00000183826 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD9 protein_coding protein_coding 2.849714 3.047147 3.2572 0.2638231 0.2800944 0.09586905 0.0610545 0.0000000 0.2001814 0.00000000 0.20018145 4.3935634 0.0199375 0.00000000 0.05243333 0.05243333 0.8123859513 1.00386e-05 FALSE TRUE
ENST00000481247 ENSG00000183826 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD9 protein_coding protein_coding 2.849714 3.047147 3.2572 0.2638231 0.2800944 0.09586905 1.7061268 1.8464996 1.5498818 0.59278310 0.06711872 -0.2511483 0.6014583 0.59426667 0.48173333 -0.11253333 0.7514539018 1.00386e-05 FALSE TRUE
ENST00000649492 ENSG00000183826 HEK293_OSMI2_2hA HEK293_TMG_2hB BTBD9 protein_coding protein_coding 2.849714 3.047147 3.2572 0.2638231 0.2800944 0.09586905 0.6706181 0.1465895 1.3475815 0.08739901 0.07483989 3.1159796 0.2374000 0.04483333 0.41873333 0.37390000 0.0000100386 1.00386e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183826 E001 233.4662262 0.0123167347 2.085443e-14 6.547580e-13 6 38168451 38171892 3442 - 2.070 2.526 1.525
ENSG00000183826 E002 271.4505099 0.0067646892 6.144050e-01 7.328874e-01 6 38171893 38174958 3066 - 2.372 2.482 0.366
ENSG00000183826 E003 33.9722449 0.0007237676 1.871904e-03 6.828673e-03 6 38174959 38175182 224 - 1.586 1.500 -0.293
ENSG00000183826 E004 23.9461134 0.0013196848 4.263857e-04 1.875667e-03 6 38192519 38192597 79 - 1.476 1.328 -0.513
ENSG00000183826 E005 31.5921788 0.0006845489 1.724681e-03 6.360560e-03 6 38256409 38256516 108 - 1.560 1.467 -0.320
ENSG00000183826 E006 38.2627420 0.0104729286 3.805081e-03 1.259542e-02 6 38288272 38288461 190 - 1.650 1.536 -0.388
ENSG00000183826 E007 24.8761708 0.0040243183 4.270028e-04 1.878251e-03 6 38344984 38345093 110 - 1.494 1.335 -0.552
ENSG00000183826 E008 0.7750806 0.0187329730 1.188965e-01 2.183609e-01 6 38402817 38402903 87 - 0.357 0.125 -1.934
ENSG00000183826 E009 0.2965864 0.1536057277 2.928720e-01   6 38504494 38504562 69 - 0.000 0.219 11.294
ENSG00000183826 E010 0.0000000       6 38571710 38571794 85 -      
ENSG00000183826 E011 0.1482932 0.0413820582 5.687000e-01   6 38577599 38577599 1 - 0.000 0.125 10.921
ENSG00000183826 E012 22.5590710 0.0117252023 4.425753e-03 1.433372e-02 6 38577600 38577719 120 - 1.448 1.299 -0.514
ENSG00000183826 E013 30.4068701 0.0051397784 4.180153e-04 1.843512e-03 6 38580218 38580437 220 - 1.572 1.425 -0.504
ENSG00000183826 E014 30.2882978 0.0054222793 3.851940e-03 1.272629e-02 6 38592576 38592840 265 - 1.549 1.441 -0.369
ENSG00000183826 E015 26.4490858 0.0041022293 1.138155e-01 2.110818e-01 6 38593964 38594235 272 - 1.448 1.431 -0.060
ENSG00000183826 E016 16.7966311 0.0520830300 1.435284e-01 2.528151e-01 6 38594236 38594327 92 - 1.297 1.199 -0.347
ENSG00000183826 E017 0.0000000       6 38594328 38594375 48 -      
ENSG00000183826 E018 0.0000000       6 38595770 38596067 298 -      
ENSG00000183826 E019 21.7894199 0.0259163986 2.762422e-03 9.559984e-03 6 38597910 38598057 148 - 1.458 1.240 -0.758
ENSG00000183826 E020 13.7930820 0.0343313590 1.161624e-03 4.510939e-03 6 38598058 38598121 64 - 1.311 0.998 -1.118
ENSG00000183826 E021 3.3966788 0.0046930143 2.896801e-01 4.303900e-01 6 38612834 38613033 200 - 0.683 0.602 -0.350
ENSG00000183826 E022 11.1221490 0.0307273961 2.744164e-03 9.504610e-03 6 38639800 38640170 371 - 1.212 0.922 -1.057