ENSG00000183814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460719 ENSG00000183814 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN9 protein_coding protein_coding 10.90063 2.673178 18.23657 0.1581856 0.4153951 2.765611 0.4668326 0.75802010 0.000000 0.44775325 0.0000000 -6.263072 0.0839250 0.266900000 0.0000 -0.26690000 3.827568e-02 8.121328e-15 FALSE TRUE
ENST00000481685 ENSG00000183814 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN9 protein_coding protein_coding 10.90063 2.673178 18.23657 0.1581856 0.4153951 2.765611 0.9418780 0.01416473 1.794640 0.01416473 0.4785595 6.222665 0.0707250 0.005033333 0.0977 0.09266667 7.374443e-04 8.121328e-15 FALSE TRUE
ENST00000681046 ENSG00000183814 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN9 protein_coding protein_coding 10.90063 2.673178 18.23657 0.1581856 0.4153951 2.765611 6.2151604 1.61785273 11.022706 0.31015996 0.5240710 2.760745 0.6052792 0.624266667 0.6051 -0.01916667 9.323566e-01 8.121328e-15 FALSE TRUE
MSTRG.3160.8 ENSG00000183814 HEK293_OSMI2_2hA HEK293_TMG_2hB LIN9 protein_coding   10.90063 2.673178 18.23657 0.1581856 0.4153951 2.765611 2.3156228 0.00000000 3.751488 0.00000000 0.2667367 8.555160 0.1311958 0.000000000 0.2053 0.20530000 8.121328e-15 8.121328e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183814 E001 0.0000000       1 226231149 226231156 8 -      
ENSG00000183814 E002 141.9400627 0.0094432592 1.027658e-13 2.916655e-12 1 226231157 226232257 1101 - 1.924 2.349 1.422
ENSG00000183814 E003 18.1750735 0.0157001510 7.641224e-05 4.110535e-04 1 226232258 226232297 40 - 1.054 1.486 1.523
ENSG00000183814 E004 17.0024842 0.0078004542 7.974945e-03 2.371491e-02 1 226232298 226232326 29 - 1.073 1.369 1.049
ENSG00000183814 E005 115.7284616 0.0007086516 3.834405e-01 5.276432e-01 1 226232327 226232606 280 - 1.927 1.992 0.218
ENSG00000183814 E006 5.8179318 0.0097364014 1.099185e-02 3.114341e-02 1 226232713 226233095 383 - 0.779 0.256 -2.644
ENSG00000183814 E007 86.6985326 0.0180641658 6.108493e-01 7.301079e-01 1 226233096 226233193 98 - 1.816 1.805 -0.037
ENSG00000183814 E008 105.7372246 0.0003443416 6.735486e-02 1.389604e-01 1 226233344 226233523 180 - 1.909 1.850 -0.200
ENSG00000183814 E009 87.5027912 0.0006101501 3.366639e-01 4.805386e-01 1 226238971 226239096 126 - 1.825 1.803 -0.075
ENSG00000183814 E010 8.8950317 0.0018815678 2.431503e-01 3.778781e-01 1 226246201 226246366 166 - 0.850 1.026 0.664
ENSG00000183814 E011 1.9229976 0.0073202983 8.091290e-02 1.609651e-01 1 226247984 226247993 10 - 0.434 0.000 -10.904
ENSG00000183814 E012 2.6572801 0.0055831056 3.111445e-02 7.412558e-02 1 226247994 226248092 99 - 0.529 0.000 -11.373
ENSG00000183814 E013 5.0682326 0.0032599355 3.201592e-01 4.632668e-01 1 226248093 226248203 111 - 0.696 0.532 -0.719
ENSG00000183814 E014 70.7941901 0.0005324302 5.496789e-01 6.793781e-01 1 226250839 226250919 81 - 1.732 1.725 -0.023
ENSG00000183814 E015 75.5667012 0.0003417374 5.461430e-01 6.763754e-01 1 226265533 226265634 102 - 1.750 1.808 0.198
ENSG00000183814 E016 88.0646794 0.0003058930 5.055482e-01 6.413148e-01 1 226266213 226266332 120 - 1.825 1.819 -0.021
ENSG00000183814 E017 94.3003550 0.0003337226 9.763463e-01 9.892159e-01 1 226267957 226268090 134 - 1.848 1.874 0.087
ENSG00000183814 E018 121.0245666 0.0003179006 9.685601e-01 9.843349e-01 1 226277775 226277932 158 - 1.955 1.981 0.086
ENSG00000183814 E019 115.1798325 0.0002531527 4.190827e-01 5.623360e-01 1 226286333 226286458 126 - 1.939 1.931 -0.028
ENSG00000183814 E020 53.5524251 0.0016531835 4.773935e-01 6.159431e-01 1 226287664 226287692 29 - 1.617 1.596 -0.071
ENSG00000183814 E021 91.3789148 0.0003061025 9.330514e-02 1.802866e-01 1 226287693 226287797 105 - 1.850 1.792 -0.194
ENSG00000183814 E022 75.8772236 0.0004341617 1.641497e-03 6.093808e-03 1 226295842 226295946 105 - 1.781 1.622 -0.539
ENSG00000183814 E023 92.7137350 0.0003323624 7.408609e-03 2.228087e-02 1 226297719 226297810 92 - 1.862 1.751 -0.377
ENSG00000183814 E024 47.9868276 0.0037036910 3.544477e-03 1.185332e-02 1 226297811 226297813 3 - 1.594 1.385 -0.719
ENSG00000183814 E025 64.0235396 0.0021473143 2.078751e-04 9.976015e-04 1 226301173 226301205 33 - 1.719 1.487 -0.792
ENSG00000183814 E026 0.1482932 0.0412142482 6.570237e-02   1 226308724 226309108 385 - 0.000 0.255 12.128
ENSG00000183814 E027 57.8055267 0.0008657099 1.298695e-03 4.971987e-03 1 226309109 226309625 517 - 1.672 1.475 -0.671
ENSG00000183814 E028 3.0418795 0.0418358228 9.111602e-01 9.475888e-01 1 226309626 226310114 489 - 0.493 0.535 0.199