ENSG00000183741

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216083 ENSG00000183741 HEK293_OSMI2_2hA HEK293_TMG_2hB CBX6 protein_coding protein_coding 80.32565 117.4741 68.3113 8.495394 0.7376268 -0.7820587 3.677784 0.00000 9.682253 0.0000000 0.8344276 9.9206882 0.05615417 0.0000000 0.14156667 0.14156667 4.140173e-67 4.140173e-67 FALSE TRUE
ENST00000407418 ENSG00000183741 HEK293_OSMI2_2hA HEK293_TMG_2hB CBX6 protein_coding protein_coding 80.32565 117.4741 68.3113 8.495394 0.7376268 -0.7820587 62.321100 90.28060 48.563228 8.4527249 0.6434333 -0.8944144 0.77465000 0.7660667 0.71093333 -0.05513333 2.366228e-01 4.140173e-67 FALSE TRUE
MSTRG.22129.7 ENSG00000183741 HEK293_OSMI2_2hA HEK293_TMG_2hB CBX6 protein_coding   80.32565 117.4741 68.3113 8.495394 0.7376268 -0.7820587 8.025293 18.66573 2.592202 0.3154313 1.3138234 -2.8433600 0.08750833 0.1603667 0.03813333 -0.12223333 3.985318e-01 4.140173e-67 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183741 E001 1.5833413 9.183487e-03 4.773063e-01 6.158880e-01 22 38858654 38858784 131 - 0.276 0.427 0.915
ENSG00000183741 E002 0.1817044 3.963813e-02 1.000000e+00   22 38859665 38859700 36 - 0.000 0.093 8.080
ENSG00000183741 E003 0.4407149 2.299509e-02 2.409116e-01 3.752454e-01 22 38860871 38860899 29 - 0.276 0.093 -1.895
ENSG00000183741 E004 14.7564252 4.898553e-02 6.149495e-04 2.588034e-03 22 38861422 38861466 45 - 0.699 1.281 2.180
ENSG00000183741 E005 7558.3309735 4.512379e-03 1.037808e-08 1.275030e-07 22 38861467 38864228 2762 - 3.728 3.887 0.526
ENSG00000183741 E006 4789.5751465 6.670772e-05 6.369063e-01 7.508587e-01 22 38864229 38865791 1563 - 3.613 3.655 0.137
ENSG00000183741 E007 1292.6886532 1.366037e-03 2.824739e-05 1.690426e-04 22 38865792 38866268 477 - 3.103 3.063 -0.135
ENSG00000183741 E008 1729.9868393 7.228459e-03 1.310239e-04 6.632663e-04 22 38866269 38867147 879 - 3.270 3.170 -0.334
ENSG00000183741 E009 331.8760635 2.205272e-03 4.836361e-04 2.097461e-03 22 38867148 38867201 54 - 2.528 2.463 -0.217
ENSG00000183741 E010 127.2450777 4.429305e-03 1.402636e-16 5.928720e-15 22 38869572 38871479 1908 - 2.270 1.937 -1.113
ENSG00000183741 E011 488.9085832 2.708987e-03 5.919943e-07 5.163515e-06 22 38871480 38871546 67 - 2.725 2.617 -0.360
ENSG00000183741 E012 524.9015569 1.769949e-03 1.881011e-11 3.745160e-10 22 38871692 38871757 66 - 2.769 2.639 -0.435
ENSG00000183741 E013 477.2609286 3.628598e-03 1.020748e-09 1.511707e-08 22 38871902 38871945 44 - 2.747 2.587 -0.535
ENSG00000183741 E014 494.4604370 5.794808e-03 3.896394e-07 3.519910e-06 22 38872122 38872323 202 - 2.761 2.604 -0.525