ENSG00000183722

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379589 ENSG00000183722 HEK293_OSMI2_2hA HEK293_TMG_2hB LHFPL6 protein_coding protein_coding 7.537988 7.438742 9.423845 0.2968246 0.4171483 0.3408491 6.5419612 7.340286 7.5060011 0.3261351 0.2063976 0.03216498 0.8923625 0.986400000 0.8017333 -0.1846667 0.0002197434 0.0002197434 FALSE TRUE
MSTRG.8612.2 ENSG00000183722 HEK293_OSMI2_2hA HEK293_TMG_2hB LHFPL6 protein_coding   7.537988 7.438742 9.423845 0.2968246 0.4171483 0.3408491 0.4697004 0.000000 0.6817868 0.0000000 0.6817868 6.11225557 0.0488500 0.000000000 0.0683000 0.0683000 0.8737402975 0.0002197434 TRUE TRUE
MSTRG.8612.4 ENSG00000183722 HEK293_OSMI2_2hA HEK293_TMG_2hB LHFPL6 protein_coding   7.537988 7.438742 9.423845 0.2968246 0.4171483 0.3408491 0.4804876 0.038268 1.1588686 0.0382680 0.5365700 4.59790199 0.0522125 0.005566667 0.1216333 0.1160667 0.0061105773 0.0002197434 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183722 E001 3.6409511 0.0410011956 6.212063e-01 7.382022e-01 13 39209116 39210104 989 - 0.611 0.710 0.423
ENSG00000183722 E002 0.5117906 0.2125250900 6.710176e-01 7.773636e-01 13 39215964 39216491 528 - 0.208 0.130 -0.818
ENSG00000183722 E003 0.4386386 0.1718515871 6.332786e-01 7.480069e-01 13 39219335 39219505 171 - 0.208 0.127 -0.854
ENSG00000183722 E004 0.0000000       13 39219821 39219866 46 -      
ENSG00000183722 E005 0.0000000       13 39220085 39220138 54 -      
ENSG00000183722 E006 0.1472490 0.0427820479 5.200348e-01   13 39227829 39227912 84 - 0.117 0.000 -10.002
ENSG00000183722 E007 0.0000000       13 39256990 39257081 92 -      
ENSG00000183722 E008 0.5202097 0.0213822814 6.030465e-01 7.239042e-01 13 39304371 39304510 140 - 0.209 0.128 -0.841
ENSG00000183722 E009 0.0000000       13 39306341 39306362 22 -      
ENSG00000183722 E010 0.0000000       13 39309806 39309861 56 -      
ENSG00000183722 E011 0.1472490 0.0427820479 5.200348e-01   13 39341658 39341693 36 - 0.117 0.000 -10.002
ENSG00000183722 E012 0.1472490 0.0427820479 5.200348e-01   13 39341788 39341821 34 - 0.117 0.000 -10.002
ENSG00000183722 E013 182.4825151 0.0036864609 3.892242e-13 1.017769e-11 13 39342892 39343723 832 - 2.114 2.368 0.847
ENSG00000183722 E014 46.9659702 0.0008275944 3.304840e-01 4.740679e-01 13 39343724 39343853 130 - 1.699 1.675 -0.080
ENSG00000183722 E015 89.2617665 0.0004003740 2.350211e-01 3.683753e-01 13 39343854 39344054 201 - 1.968 1.951 -0.057
ENSG00000183722 E016 67.7390122 0.0005187166 5.791617e-01 7.041170e-01 13 39378428 39378526 99 - 1.836 1.837 0.005
ENSG00000183722 E017 149.4055096 0.0003034999 3.192277e-03 1.083288e-02 13 39600832 39601312 481 - 2.207 2.156 -0.173
ENSG00000183722 E018 46.0386732 0.0009275403 7.407201e-04 3.045427e-03 13 39601313 39601390 78 - 1.749 1.603 -0.495
ENSG00000183722 E019 51.9996997 0.0004832265 1.145783e-03 4.456731e-03 13 39602883 39603033 151 - 1.788 1.660 -0.435
ENSG00000183722 E020 30.8821227 0.0031722268 2.313520e-02 5.802875e-02 13 39603034 39603226 193 - 1.562 1.434 -0.438
ENSG00000183722 E021 0.0000000       13 39603312 39603528 217 -