ENSG00000183696

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395560 ENSG00000183696 HEK293_OSMI2_2hA HEK293_TMG_2hB UPP1 protein_coding nonsense_mediated_decay 12.97731 24.8608 8.23016 0.9982357 0.1783802 -1.593709 4.0612977 10.0318551 2.0536294 0.36703042 0.25499201 -2.2827700 0.28480417 0.40383333 0.24853333 -0.155300000 2.873607e-03 7.768094e-09 FALSE TRUE
ENST00000395564 ENSG00000183696 HEK293_OSMI2_2hA HEK293_TMG_2hB UPP1 protein_coding protein_coding 12.97731 24.8608 8.23016 0.9982357 0.1783802 -1.593709 3.4064928 6.7105743 2.3027633 0.04040242 0.07248915 -1.5389669 0.26263750 0.27093333 0.27986667 0.008933333 9.285362e-01 7.768094e-09 FALSE TRUE
ENST00000421046 ENSG00000183696 HEK293_OSMI2_2hA HEK293_TMG_2hB UPP1 protein_coding nonsense_mediated_decay 12.97731 24.8608 8.23016 0.9982357 0.1783802 -1.593709 0.5807264 0.8891635 0.4709750 0.46475427 0.08273078 -0.9026215 0.05970417 0.03433333 0.05696667 0.022633333 7.314383e-01 7.768094e-09 FALSE TRUE
ENST00000444999 ENSG00000183696 HEK293_OSMI2_2hA HEK293_TMG_2hB UPP1 protein_coding nonsense_mediated_decay 12.97731 24.8608 8.23016 0.9982357 0.1783802 -1.593709 0.5243952 0.0000000 0.7335808 0.00000000 0.22074071 6.2164176 0.04960833 0.00000000 0.08930000 0.089300000 7.768094e-09 7.768094e-09 FALSE FALSE
MSTRG.29842.3 ENSG00000183696 HEK293_OSMI2_2hA HEK293_TMG_2hB UPP1 protein_coding   12.97731 24.8608 8.23016 0.9982357 0.1783802 -1.593709 3.3584840 5.4391010 2.0093485 0.34578214 0.22604148 -1.4321283 0.25255833 0.21853333 0.24546667 0.026933333 7.967210e-01 7.768094e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183696 E001 0.6600838 0.0495784584 0.2443327124 0.3792831865 7 48088628 48088643 16 + 0.344 0.131 -1.780
ENSG00000183696 E002 0.6600838 0.0495784584 0.2443327124 0.3792831865 7 48088644 48088644 1 + 0.344 0.131 -1.780
ENSG00000183696 E003 0.6600838 0.0495784584 0.2443327124 0.3792831865 7 48088645 48088660 16 + 0.344 0.131 -1.780
ENSG00000183696 E004 1.7317362 0.0087064972 0.2219735955 0.3527694222 7 48088661 48088726 66 + 0.533 0.313 -1.195
ENSG00000183696 E005 4.0202112 0.0389118179 0.9815436920 0.9925247680 7 48088727 48088908 182 + 0.604 0.605 0.003
ENSG00000183696 E006 2.0262448 0.0078834444 0.7249360819 0.8183101571 7 48088909 48088923 15 + 0.344 0.412 0.391
ENSG00000183696 E007 19.3762840 0.0009786546 0.5372464051 0.6688553572 7 48089212 48089226 15 + 1.253 1.197 -0.196
ENSG00000183696 E008 44.0308185 0.0005213883 0.4763574759 0.6149791115 7 48089227 48089264 38 + 1.584 1.541 -0.150
ENSG00000183696 E009 39.3632846 0.0005745102 0.3770724908 0.5214023631 7 48089265 48089271 7 + 1.549 1.492 -0.196
ENSG00000183696 E010 45.5805713 0.0005370108 0.9088084942 0.9460627357 7 48089272 48089281 10 + 1.571 1.564 -0.022
ENSG00000183696 E011 81.9042038 0.0005571448 0.7505247110 0.8371879632 7 48089282 48089343 62 + 1.800 1.816 0.053
ENSG00000183696 E012 72.3259402 0.0004642182 0.5330677042 0.6653100471 7 48089344 48089375 32 + 1.733 1.765 0.109
ENSG00000183696 E013 85.7155500 0.0028392989 0.6781530843 0.7827007552 7 48089376 48089418 43 + 1.813 1.836 0.078
ENSG00000183696 E014 0.3697384 0.0247505358 0.8575912265 0.9120656878 7 48089509 48089636 128 + 0.001 0.131 7.465
ENSG00000183696 E015 122.1774314 0.0019986410 0.6085868252 0.7282926078 7 48090188 48090249 62 + 2.000 1.980 -0.067
ENSG00000183696 E016 180.3130893 0.0002051121 0.9022663438 0.9417306787 7 48090250 48090364 115 + 2.157 2.153 -0.010
ENSG00000183696 E017 161.9684995 0.0002394572 0.7615631756 0.8453894770 7 48094763 48094827 65 + 2.100 2.111 0.036
ENSG00000183696 E018 62.7660493 0.0004416785 0.0790267550 0.1579576251 7 48099670 48099787 118 + 1.770 1.680 -0.305
ENSG00000183696 E019 48.2123408 0.0005933347 0.0719183060 0.1465211352 7 48101824 48101870 47 + 1.671 1.566 -0.356
ENSG00000183696 E020 58.6376013 0.0004638380 0.0932745030 0.1802402591 7 48101871 48101982 112 + 1.743 1.654 -0.301
ENSG00000183696 E021 59.5695476 0.0004297736 0.0312078070 0.0743040596 7 48103297 48103411 115 + 1.770 1.659 -0.378
ENSG00000183696 E022 1.4425367 0.0190378919 0.3502400676 0.4944330772 7 48103412 48103413 2 + 0.449 0.274 -1.040
ENSG00000183696 E023 2.7409475 0.0447356106 0.0296574629 0.0712919346 7 48103782 48103991 210 + 0.766 0.383 -1.771
ENSG00000183696 E024 34.5162772 0.0153922807 0.0001254513 0.0006386922 7 48104646 48106872 2227 + 1.687 1.369 -1.090
ENSG00000183696 E025 303.7450825 0.0008358296 0.0311968684 0.0742836169 7 48106873 48107082 210 + 2.335 2.393 0.192
ENSG00000183696 E026 203.3456957 0.0021600349 0.0156531857 0.0419636597 7 48107361 48107507 147 + 2.136 2.226 0.300
ENSG00000183696 E027 114.9547469 0.0003084221 0.0098110550 0.0282967944 7 48108218 48108736 519 + 1.873 1.981 0.362