ENSG00000183684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000505490 ENSG00000183684 HEK293_OSMI2_2hA HEK293_TMG_2hB ALYREF protein_coding protein_coding 374.0049 729.1826 192.3795 18.35933 6.169177 -1.92227 164.0278 193.6492 162.11040 35.74936 6.901588 -0.2564547 0.4671208 0.2641333 0.8424 0.5782667 1.384250e-15 1.38425e-15 FALSE TRUE
MSTRG.15310.3 ENSG00000183684 HEK293_OSMI2_2hA HEK293_TMG_2hB ALYREF protein_coding   374.0049 729.1826 192.3795 18.35933 6.169177 -1.92227 205.0701 529.3855 26.67469 26.82715 4.374959 -4.3102617 0.5174375 0.7275667 0.1391 -0.5884667 3.043451e-13 1.38425e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183684 E001 35.0934174 0.0010289351 3.079660e-01 4.501967e-01 17 81887835 81887839 5 - 1.384 1.444 0.209
ENSG00000183684 E002 47.3400443 0.0009571674 3.598755e-02 8.355885e-02 17 81887840 81887840 1 - 1.450 1.578 0.440
ENSG00000183684 E003 3741.9075727 0.0015575684 2.214392e-20 1.479753e-18 17 81887841 81888145 305 - 3.306 3.468 0.539
ENSG00000183684 E004 4467.5073991 0.0004163597 1.049395e-16 4.500900e-15 17 81888241 81888340 100 - 3.459 3.533 0.247
ENSG00000183684 E005 5313.2307276 0.0003610185 7.014733e-03 2.126204e-02 17 81888341 81888418 78 - 3.590 3.598 0.029
ENSG00000183684 E006 4921.0703890 0.0004424600 7.916764e-02 1.581814e-01 17 81888520 81888583 64 - 3.562 3.564 0.005
ENSG00000183684 E007 24.2104478 0.0044112532 9.609252e-06 6.414079e-05 17 81888876 81888900 25 - 1.566 1.191 -1.302
ENSG00000183684 E008 29.8908714 0.0006680324 3.889071e-09 5.168717e-08 17 81888901 81888989 89 - 1.682 1.261 -1.448
ENSG00000183684 E009 5576.5599120 0.0001053670 2.579415e-02 6.351791e-02 17 81889182 81889300 119 - 3.620 3.617 -0.011
ENSG00000183684 E010 2828.9037943 0.0001766113 2.580764e-02 6.354371e-02 17 81889301 81889329 29 - 3.319 3.323 0.012
ENSG00000183684 E011 15.2648517 0.0031409746 6.581347e-03 2.013885e-02 17 81889783 81889969 187 - 1.306 1.019 -1.026
ENSG00000183684 E012 3696.8303248 0.0007401619 3.203427e-04 1.462185e-03 17 81890689 81890820 132 - 3.495 3.427 -0.226
ENSG00000183684 E013 10.0440792 0.0017951429 4.030847e-01 5.468772e-01 17 81890821 81891005 185 - 0.843 0.938 0.362
ENSG00000183684 E014 0.8126288 0.2099319624 4.686427e-01 6.080525e-01 17 81891191 81891322 132 - 0.001 0.219 9.036
ENSG00000183684 E015 1223.4837203 0.0046252190 8.539351e-15 2.839162e-13 17 81891323 81891408 86 - 3.181 2.897 -0.944
ENSG00000183684 E016 513.2251698 0.0208555191 1.052613e-15 3.962137e-14 17 81891409 81891498 90 - 3.006 2.410 -1.983
ENSG00000183684 E017 297.5512104 0.0166913935 2.876313e-28 4.165969e-26 17 81891499 81891609 111 - 2.856 2.092 -2.546