ENSG00000183647

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000597700 ENSG00000183647 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF530 protein_coding protein_coding 9.298734 16.64526 5.094866 0.5316639 0.9736808 -1.706033 0.9048737 0.8083011 0.80227846 0.04188077 0.11713319 -0.01065747 0.13105417 0.04863333 0.17283333 0.12420000 0.005782338 3.390725e-05 FALSE TRUE
ENST00000597864 ENSG00000183647 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF530 protein_coding protein_coding 9.298734 16.64526 5.094866 0.5316639 0.9736808 -1.706033 2.3480461 4.1914732 1.21165599 0.52046554 0.62439451 -1.78205719 0.22301250 0.25080000 0.21610000 -0.03470000 0.836456940 3.390725e-05   FALSE
ENST00000600619 ENSG00000183647 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF530 protein_coding nonsense_mediated_decay 9.298734 16.64526 5.094866 0.5316639 0.9736808 -1.706033 0.5584905 0.2760324 0.98236950 0.14382666 0.07186383 1.79469871 0.09650417 0.01693333 0.20523333 0.18830000 0.004936100 3.390725e-05 TRUE TRUE
MSTRG.17802.1 ENSG00000183647 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF530 protein_coding   9.298734 16.64526 5.094866 0.5316639 0.9736808 -1.706033 3.0740500 7.5026008 1.04820889 0.59042531 0.52473679 -2.82768801 0.28241667 0.44966667 0.22430000 -0.22536667 0.579986676 3.390725e-05   FALSE
MSTRG.17802.6 ENSG00000183647 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF530 protein_coding   9.298734 16.64526 5.094866 0.5316639 0.9736808 -1.706033 0.6447482 1.5075330 0.08718193 0.26815885 0.08718193 -3.96489599 0.06274583 0.08980000 0.01270000 -0.07710000 0.054983217 3.390725e-05   FALSE
MSTRG.17802.7 ENSG00000183647 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF530 protein_coding   9.298734 16.64526 5.094866 0.5316639 0.9736808 -1.706033 1.2141181 2.2258005 0.55118008 0.56545442 0.27589248 -1.99425579 0.12136250 0.13593333 0.09646667 -0.03946667 0.782850796 3.390725e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183647 E001 0.7363563 0.0371464441 6.715154e-01 7.777121e-01 19 57599884 57599884 1 + 0.164 0.229 0.595
ENSG00000183647 E002 1.2877991 0.0124098645 2.195449e-01 3.498429e-01 19 57599885 57599891 7 + 0.164 0.378 1.593
ENSG00000183647 E003 3.4257036 0.0098972709 1.544810e-02 4.150846e-02 19 57599892 57599902 11 + 0.283 0.693 2.098
ENSG00000183647 E004 82.0434801 0.0004312703 6.930702e-17 3.046406e-15 19 57599903 57600134 232 + 1.622 1.952 1.118
ENSG00000183647 E005 21.8792655 0.0009789969 1.069450e-01 2.010261e-01 19 57600728 57600779 52 + 1.255 1.351 0.338
ENSG00000183647 E006 28.4667387 0.0008640235 7.640257e-06 5.212936e-05 19 57604277 57604279 3 + 1.195 1.501 1.063
ENSG00000183647 E007 66.3223303 0.0015302274 5.481014e-11 1.010473e-09 19 57604280 57604406 127 + 1.555 1.854 1.015
ENSG00000183647 E008 3.4686638 0.0122750679 6.007460e-06 4.201399e-05 19 57604655 57605685 1031 + 0.988 0.284 -3.241
ENSG00000183647 E009 41.7400855 0.0007774385 1.974912e-26 2.432647e-24 19 57605686 57606443 758 + 1.915 1.342 -1.953
ENSG00000183647 E010 68.5689839 0.0090932271 1.197504e-14 3.893318e-13 19 57606444 57607827 1384 + 2.067 1.626 -1.486
ENSG00000183647 E011 53.0058955 0.0022615730 3.435730e-06 2.539261e-05 19 57607828 57610098 2271 + 1.861 1.606 -0.863
ENSG00000183647 E012 56.5612877 0.0050051592 6.640206e-12 1.423684e-10 19 57612503 57612722 220 + 1.403 1.804 1.366