ENSG00000183605

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355697 ENSG00000183605 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN4 protein_coding protein_coding 56.91294 71.7091 48.25489 14.01628 0.8694372 -0.5713833 35.05519 35.47101 36.682698 5.864598 1.541077 0.04844582 0.63884167 0.5014000 0.76170000 0.26030000 0.00197781 0.00197781 FALSE TRUE
MSTRG.4718.6 ENSG00000183605 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN4 protein_coding   56.91294 71.7091 48.25489 14.01628 0.8694372 -0.5713833 5.02885 10.40574 3.915291 1.490537 2.050234 -1.40789336 0.08891667 0.1571333 0.08146667 -0.07566667 0.71997402 0.00197781 FALSE TRUE
MSTRG.4718.7 ENSG00000183605 HEK293_OSMI2_2hA HEK293_TMG_2hB SFXN4 protein_coding   56.91294 71.7091 48.25489 14.01628 0.8694372 -0.5713833 13.88936 21.77808 5.470871 6.955860 3.005393 -1.99106185 0.21858750 0.2851333 0.11140000 -0.17373333 0.60084952 0.00197781 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183605 E001 7.3655144 0.0024438493 0.0079263320 0.023594052 10 119140767 119140912 146 - 1.082 0.776 -1.157
ENSG00000183605 E002 8.4670793 0.0021602785 0.1295481123 0.233526670 10 119140913 119140927 15 - 1.067 0.900 -0.616
ENSG00000183605 E003 62.7448758 0.0004128815 0.0847222221 0.166960053 10 119140928 119140964 37 - 1.735 1.816 0.276
ENSG00000183605 E004 66.6328538 0.0013704963 0.1232450593 0.224603255 10 119140965 119140966 2 - 1.764 1.839 0.251
ENSG00000183605 E005 617.7807290 0.0011180807 0.0189925294 0.049316434 10 119140967 119141255 289 - 2.740 2.786 0.155
ENSG00000183605 E006 387.8748138 0.0017572657 0.0154970043 0.041622754 10 119141256 119141313 58 - 2.526 2.590 0.214
ENSG00000183605 E007 235.8684815 0.0008960866 0.6187900241 0.736344803 10 119141314 119141319 6 - 2.349 2.363 0.046
ENSG00000183605 E008 9.8771472 0.0017142178 0.5069485790 0.642587075 10 119142253 119142373 121 - 1.067 0.997 -0.254
ENSG00000183605 E009 382.9619901 0.0002465296 0.0067838190 0.020660303 10 119146236 119146289 54 - 2.532 2.586 0.177
ENSG00000183605 E010 396.8158926 0.0002967634 0.0001483970 0.000739981 10 119146290 119146353 64 - 2.532 2.607 0.250
ENSG00000183605 E011 209.6750180 0.0026862776 0.0357400454 0.083079884 10 119147775 119147777 3 - 2.254 2.326 0.238
ENSG00000183605 E012 437.5657596 0.0027679461 0.0027098255 0.009403039 10 119147778 119147860 83 - 2.560 2.646 0.286
ENSG00000183605 E013 597.3782212 0.0001364184 0.0006157265 0.002590958 10 119155062 119155177 116 - 2.725 2.777 0.173
ENSG00000183605 E014 459.8553560 0.0001497797 0.0074500847 0.022385443 10 119156678 119156756 79 - 2.615 2.661 0.154
ENSG00000183605 E015 187.3206790 0.0002341856 0.0786222255 0.157288454 10 119157668 119157668 1 - 2.226 2.273 0.160
ENSG00000183605 E016 380.9955137 0.0001395642 0.9116845067 0.947957139 10 119157669 119157733 65 - 2.564 2.565 0.005
ENSG00000183605 E017 385.4357478 0.0001748614 0.0044019838 0.014270065 10 119157871 119157927 57 - 2.606 2.551 -0.181
ENSG00000183605 E018 3.3733921 0.0853352685 0.1699061894 0.288091882 10 119158007 119158008 2 - 0.432 0.679 1.148
ENSG00000183605 E019 351.8085162 0.0001696575 0.0017412792 0.006412309 10 119158009 119158062 54 - 2.570 2.508 -0.208
ENSG00000183605 E020 264.4522037 0.0002597109 0.0133083334 0.036638240 10 119159728 119159753 26 - 2.444 2.386 -0.194
ENSG00000183605 E021 328.1344521 0.0002172846 0.0212062916 0.054025098 10 119160915 119160969 55 - 2.532 2.483 -0.161
ENSG00000183605 E022 263.5211907 0.0001933665 0.0100725821 0.028940056 10 119161055 119161081 27 - 2.444 2.385 -0.196
ENSG00000183605 E023 1.6543189 0.4381491445 0.5120989505 0.647029544 10 119162139 119162160 22 - 0.551 0.306 -1.321
ENSG00000183605 E024 354.5972194 0.0006588975 0.0002328960 0.001103643 10 119162340 119162414 75 - 2.587 2.500 -0.292
ENSG00000183605 E025 365.3497681 0.0024072461 0.0004746100 0.002062897 10 119164131 119164196 66 - 2.616 2.498 -0.393
ENSG00000183605 E026 25.1832146 0.0129224708 0.7248559537 0.818263423 10 119165202 119165536 335 - 1.381 1.399 0.063
ENSG00000183605 E027 319.5784653 0.0071317731 0.0033989918 0.011434865 10 119165537 119165632 96 - 2.578 2.423 -0.519
ENSG00000183605 E028 171.6692982 0.0047705059 0.0011637101 0.004517929 10 119165633 119165715 83 - 2.312 2.155 -0.524
ENSG00000183605 E029 0.2965864 0.0434122210 0.3963982111   10 119165934 119166019 86 - 0.000 0.174 9.251
ENSG00000183605 E030 1.0573857 0.7894834092 0.3264089213 0.469855336 10 119166020 119166189 170 - 0.556 0.093 -3.438