ENSG00000183597

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327374 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding protein_coding 17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 1.1896050 1.918913 0.4977856 0.3526063 0.49778565 -1.9254967 0.06826250 0.07046667 0.04536667 -0.02510000 0.302893204 0.008016381 FALSE  
ENST00000398042 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding protein_coding 17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 1.2665017 2.514698 1.1494035 0.4035644 0.09241276 -1.1227283 0.07207917 0.09003333 0.10750000 0.01746667 0.771086189 0.008016381 FALSE  
ENST00000450664 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding protein_coding 17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 0.8605254 1.140429 0.3500885 1.1404288 0.35008849 -1.6757483 0.05414167 0.03740000 0.03190000 -0.00550000 0.951658869 0.008016381 FALSE  
ENST00000462579 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding retained_intron 17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 2.0892742 2.857623 1.9421508 0.2996963 0.24957227 -0.5547906 0.13926667 0.10230000 0.17776667 0.07546667 0.008016381 0.008016381 FALSE  
ENST00000476940 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding processed_transcript 17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 1.3771707 3.027237 0.6057097 0.7984968 0.34620088 -2.3024374 0.06637083 0.10923333 0.05866667 -0.05056667 0.628911217 0.008016381    
ENST00000490121 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding processed_transcript 17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 0.6098166 0.000000 0.7581324 0.0000000 0.75813238 6.2632831 0.03802083 0.00000000 0.06336667 0.06336667 0.711150909 0.008016381    
MSTRG.21650.14 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding   17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 1.6679940 4.060135 0.4355948 0.4333405 0.43559476 -3.1912726 0.08571250 0.14583333 0.04520000 -0.10063333 0.149766966 0.008016381 FALSE  
MSTRG.21650.16 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding   17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 0.9201940 1.760214 0.6922756 0.1952392 0.40519504 -1.3338144 0.05327083 0.06310000 0.06140000 -0.00170000 0.835746888 0.008016381 TRUE  
MSTRG.21650.18 ENSG00000183597 HEK293_OSMI2_2hA HEK293_TMG_2hB TANGO2 protein_coding   17.16515 27.93807 10.85909 1.857459 0.6741454 -1.362517 2.0754693 3.730515 1.5225171 0.7818765 0.35927010 -1.2873339 0.12142083 0.13153333 0.14553333 0.01400000 0.976574029 0.008016381 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183597 E001 0.9943332 0.0151238408 0.2246563196 0.3560201205 22 20017014 20017030 17 + 0.000 0.286 11.709
ENSG00000183597 E002 1.9478959 0.0077016189 0.7373513428 0.8275628141 22 20017031 20017192 162 + 0.432 0.396 -0.195
ENSG00000183597 E003 0.2214452 0.0382947195 1.0000000000   22 20019181 20019299 119 + 0.000 0.074 11.362
ENSG00000183597 E004 0.0000000       22 20021069 20021071 3 +      
ENSG00000183597 E005 0.0000000       22 20021072 20021088 17 +      
ENSG00000183597 E006 0.2934659 0.0299697059 0.3754144227   22 20021089 20021101 13 + 0.196 0.074 -1.613
ENSG00000183597 E007 0.2934659 0.0299697059 0.3754144227   22 20021102 20021105 4 + 0.196 0.074 -1.613
ENSG00000183597 E008 0.5858876 0.0204317886 0.0292298311 0.0704508061 22 20021106 20021106 1 + 0.432 0.074 -3.197
ENSG00000183597 E009 0.9158852 0.0140124970 0.1525354425 0.2651296684 22 20021107 20021107 1 + 0.432 0.192 -1.613
ENSG00000183597 E010 1.6919954 0.0083345207 0.2326508243 0.3655947039 22 20021108 20021109 2 + 0.515 0.326 -1.026
ENSG00000183597 E011 5.9951912 0.0152356316 0.1259776119 0.2285388220 22 20021110 20021121 12 + 0.893 0.710 -0.726
ENSG00000183597 E012 15.8437503 0.0015117582 0.4434135817 0.5849939262 22 20021122 20021126 5 + 1.166 1.130 -0.129
ENSG00000183597 E013 25.0233436 0.0013919685 0.4379775561 0.5798533416 22 20021127 20021134 8 + 1.343 1.321 -0.078
ENSG00000183597 E014 4.0804053 0.0044526512 0.1437494822 0.2531174659 22 20021135 20021138 4 + 0.787 0.599 -0.782
ENSG00000183597 E015 5.7421971 0.0028235952 0.1056727916 0.1991167121 22 20021139 20021154 16 + 0.893 0.707 -0.736
ENSG00000183597 E016 12.7701301 0.0014492319 0.0415362221 0.0938804042 22 20021155 20021246 92 + 1.182 1.013 -0.611
ENSG00000183597 E017 0.6244956 0.0200247539 0.2428726587 0.3775581095 22 20021247 20021298 52 + 0.330 0.137 -1.612
ENSG00000183597 E018 0.5202097 0.0203310131 0.1090855915 0.2041955551 22 20036759 20036759 1 + 0.330 0.074 -2.609
ENSG00000183597 E019 66.9184226 0.0004402084 0.1649212813 0.2816003640 22 20036760 20036854 95 + 1.763 1.735 -0.094
ENSG00000183597 E020 50.0518753 0.0004710767 0.0903625797 0.1756903840 22 20036855 20037094 240 + 1.662 1.607 -0.186
ENSG00000183597 E021 106.5995507 0.0006038795 0.1215693571 0.2221713630 22 20043355 20043443 89 + 1.958 1.938 -0.068
ENSG00000183597 E022 3.2774275 0.0048203421 0.0913556302 0.1772446113 22 20047970 20048328 359 + 0.744 0.510 -1.027
ENSG00000183597 E023 130.8949345 0.0003625763 0.9073599279 0.9451828063 22 20052465 20052584 120 + 2.002 2.041 0.128
ENSG00000183597 E024 2.6433786 0.0062660436 0.7886725063 0.8647107456 22 20053360 20053434 75 + 0.432 0.510 0.390
ENSG00000183597 E025 2.0135724 0.0364692889 0.7118442682 0.8087114952 22 20053435 20053436 2 + 0.330 0.429 0.570
ENSG00000183597 E026 56.5589473 0.0103707949 0.0125977968 0.0349646166 22 20053437 20053551 115 + 1.477 1.715 0.810
ENSG00000183597 E027 22.7143390 0.0229463650 0.0007773194 0.0031776283 22 20053552 20055942 2391 + 1.501 1.203 -1.036
ENSG00000183597 E028 78.8478915 0.0003585385 0.4921807591 0.6293852652 22 20055943 20056013 71 + 1.807 1.817 0.034
ENSG00000183597 E029 6.4462787 0.0027741862 0.0001463012 0.0007311472 22 20056014 20056241 228 + 1.093 0.657 -1.684
ENSG00000183597 E030 8.0090196 0.0035395594 0.0034687180 0.0116352954 22 20061174 20061227 54 + 1.093 0.781 -1.177
ENSG00000183597 E031 105.9364831 0.0021348858 0.5426088850 0.6733279105 22 20061530 20061681 152 + 1.930 1.946 0.054
ENSG00000183597 E032 30.4657627 0.0006984807 0.0256143095 0.0631514068 22 20061682 20061683 2 + 1.501 1.385 -0.400
ENSG00000183597 E033 10.7104116 0.0018812705 0.0732608791 0.1487329293 22 20061684 20061706 23 + 1.112 0.954 -0.578
ENSG00000183597 E034 13.0451010 0.0013480752 0.0100998256 0.0290077721 22 20061707 20061802 96 + 1.229 1.013 -0.775
ENSG00000183597 E035 97.3544229 0.0003201917 0.4456856182 0.5872203799 22 20063338 20063442 105 + 1.894 1.904 0.034
ENSG00000183597 E036 14.1687813 0.0012992554 0.7045618882 0.8030873682 22 20063573 20063598 26 + 1.093 1.092 -0.001
ENSG00000183597 E037 924.1875705 0.0056416666 0.0019448177 0.0070551266 22 20064542 20067164 2623 + 2.785 2.901 0.386
ENSG00000183597 E038 24.8458359 0.0055062141 0.1450233916 0.2548631398 22 20067739 20067947 209 + 1.182 1.361 0.627