ENSG00000183576

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329331 ENSG00000183576 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD3 protein_coding protein_coding 23.48323 20.0164 28.56513 0.9761052 0.7554792 0.5128567 1.539050 1.9157769 1.679506 0.1809393 0.2646664 -0.1888391 0.07047917 0.09576667 0.05873333 -0.03703333 1.247770e-01 1.132367e-12 FALSE TRUE
ENST00000331768 ENSG00000183576 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD3 protein_coding protein_coding 23.48323 20.0164 28.56513 0.9761052 0.7554792 0.5128567 17.334671 16.9020292 19.370666 0.8225012 0.5135580 0.1965684 0.75228750 0.84440000 0.67820000 -0.16620000 1.132367e-12 1.132367e-12 FALSE TRUE
MSTRG.10161.1 ENSG00000183576 HEK293_OSMI2_2hA HEK293_TMG_2hB SETD3 protein_coding   23.48323 20.0164 28.56513 0.9761052 0.7554792 0.5128567 2.758612 0.4493399 5.680646 0.2405932 0.6834739 3.6309585 0.10238750 0.02270000 0.19793333 0.17523333 2.896745e-02 1.132367e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183576 E001 5.0025340 0.0631335527 4.057603e-01 5.494055e-01 14 99396447 99396560 114 - 0.711 0.862 0.599
ENSG00000183576 E002 356.4585848 0.0009422745 7.807601e-15 2.608689e-13 14 99397748 99398468 721 - 2.459 2.636 0.588
ENSG00000183576 E003 178.8339721 0.0002049012 4.939266e-08 5.331182e-07 14 99398469 99398646 178 - 2.178 2.323 0.485
ENSG00000183576 E004 93.7057869 0.0003197971 3.907817e-05 2.258050e-04 14 99398647 99398672 26 - 1.899 2.051 0.508
ENSG00000183576 E005 141.8671588 0.0009698565 1.161518e-03 4.510620e-03 14 99398673 99398731 59 - 2.103 2.209 0.357
ENSG00000183576 E006 424.8939820 0.0018327248 3.288606e-02 7.757356e-02 14 99398732 99399125 394 - 2.603 2.658 0.182
ENSG00000183576 E007 233.9396611 0.0027358745 1.470170e-01 2.576211e-01 14 99400099 99400259 161 - 2.347 2.394 0.155
ENSG00000183576 E008 154.3871387 0.0002158428 5.026871e-01 6.387246e-01 14 99404225 99404310 86 - 2.182 2.203 0.068
ENSG00000183576 E009 169.3569113 0.0002525508 4.967944e-01 6.333876e-01 14 99405205 99405314 110 - 2.222 2.242 0.066
ENSG00000183576 E010 117.9374094 0.0069014929 7.362381e-01 8.267818e-01 14 99405315 99405371 57 - 2.068 2.082 0.047
ENSG00000183576 E011 142.4219901 0.0003492529 2.715496e-02 6.631296e-02 14 99406516 99406590 75 - 2.189 2.124 -0.217
ENSG00000183576 E012 0.2214452 0.0393952090 4.064545e-01   14 99409804 99409804 1 - 0.000 0.133 10.296
ENSG00000183576 E013 29.1449854 0.0163342286 1.499265e-04 7.466593e-04 14 99409805 99410215 411 - 1.274 1.616 1.179
ENSG00000183576 E014 1.2523272 0.0103029427 6.540924e-01 7.643754e-01 14 99411279 99411577 299 - 0.395 0.316 -0.469
ENSG00000183576 E015 6.3192340 0.0125517058 2.148560e-01 3.442736e-01 14 99411578 99412950 1373 - 0.940 0.778 -0.626
ENSG00000183576 E016 181.9709607 0.0003249375 1.901719e-03 6.920113e-03 14 99412951 99413065 115 - 2.304 2.223 -0.270
ENSG00000183576 E017 0.8921407 0.0132572489 1.423395e-02 3.875806e-02 14 99413066 99413250 185 - 0.444 0.000 -12.615
ENSG00000183576 E018 149.2912728 0.0012753354 1.564957e-04 7.760553e-04 14 99413876 99413934 59 - 2.237 2.116 -0.406
ENSG00000183576 E019 109.2673915 0.0016924337 8.079072e-04 3.286782e-03 14 99458279 99458298 20 - 2.104 1.978 -0.423
ENSG00000183576 E020 254.8021167 0.0002250706 1.109118e-07 1.117476e-06 14 99458299 99458535 237 - 2.463 2.346 -0.391
ENSG00000183576 E021 123.4912618 0.0077339036 3.037391e-02 7.270051e-02 14 99459113 99459185 73 - 2.150 2.031 -0.399
ENSG00000183576 E022 166.6646631 0.0055475825 6.745699e-03 2.056272e-02 14 99461192 99461340 149 - 2.283 2.160 -0.412
ENSG00000183576 E023 123.6798116 0.0117897071 1.138513e-01 2.111358e-01 14 99463486 99463578 93 - 2.144 2.045 -0.332
ENSG00000183576 E024 109.3580964 0.0013536249 1.994253e-04 9.613608e-04 14 99465703 99465813 111 - 2.108 1.967 -0.471
ENSG00000183576 E025 1.2512699 0.0108102148 2.383253e-01 3.722024e-01 14 99475160 99475291 132 - 0.444 0.234 -1.316
ENSG00000183576 E026 0.3289534 0.0286545809 8.931490e-01   14 99478739 99478769 31 - 0.113 0.133 0.269
ENSG00000183576 E027 78.9871926 0.0004808770 2.624858e-08 2.990207e-07 14 99480728 99480889 162 - 2.001 1.775 -0.762