ENSG00000183520

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373014 ENSG00000183520 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP11 protein_coding protein_coding 61.88096 40.35972 99.6524 2.421323 3.795862 1.303776 32.30623 30.343010 44.95298 2.413423 2.205890 0.5668982 0.5718208 0.7566 0.4509 -0.3057 0.02939325 0.02939325 FALSE TRUE
ENST00000483182 ENSG00000183520 HEK293_OSMI2_2hA HEK293_TMG_2hB UTP11 protein_coding processed_transcript 61.88096 40.35972 99.6524 2.421323 3.795862 1.303776 29.00675 9.819834 53.94247 3.440673 2.041861 2.4564502 0.4168875 0.2384 0.5415 0.3031 0.03900778 0.02939325 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183520 E001 1.301531 0.0205910821 5.321708e-01 6.645497e-01 1 38009258 38009348 91 + 0.307 0.423 0.682
ENSG00000183520 E002 14.218808 0.0062835576 1.611509e-03 5.997830e-03 1 38012714 38012733 20 + 1.284 0.967 -1.142
ENSG00000183520 E003 339.393216 0.0079274626 1.256961e-03 4.833112e-03 1 38012734 38012865 132 + 2.583 2.438 -0.484
ENSG00000183520 E004 377.127029 0.0059765262 8.784623e-04 3.538862e-03 1 38016359 38016420 62 + 2.624 2.493 -0.437
ENSG00000183520 E005 2.317842 0.0915533923 7.898267e-02 1.578878e-01 1 38016421 38016582 162 + 0.637 0.263 -2.003
ENSG00000183520 E006 13.144262 0.0185031415 2.702940e-02 6.605656e-02 1 38016583 38017667 1085 + 1.242 1.000 -0.871
ENSG00000183520 E007 565.184742 0.0010402588 1.463695e-10 2.512392e-09 1 38017668 38017770 103 + 2.798 2.671 -0.422
ENSG00000183520 E008 580.497017 0.0003359282 9.404738e-07 7.848204e-06 1 38018464 38018577 114 + 2.791 2.716 -0.247
ENSG00000183520 E009 531.816809 0.0006190476 1.062499e-02 3.027330e-02 1 38019059 38019152 94 + 2.740 2.698 -0.140
ENSG00000183520 E010 721.607735 0.0014611008 2.671470e-05 1.608512e-04 1 38019253 38019383 131 + 2.814 2.907 0.309
ENSG00000183520 E011 682.893243 0.0005224199 2.049791e-13 5.575401e-12 1 38022699 38022809 111 + 2.775 2.899 0.411
ENSG00000183520 E012 849.892714 0.0023120634 1.334221e-07 1.323304e-06 1 38023545 38024820 1276 + 2.868 2.994 0.419