ENSG00000183513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328709 ENSG00000183513 HEK293_OSMI2_2hA HEK293_TMG_2hB COA5 protein_coding protein_coding 22.24464 18.21214 24.65569 2.84176 1.656055 0.4368131 7.431605 5.031385 9.852899 0.6649853 0.02875476 0.9681916 0.32462083 0.2784333 0.40313333 0.12470000 0.01076223 0.01076223   FALSE
ENST00000466848 ENSG00000183513 HEK293_OSMI2_2hA HEK293_TMG_2hB COA5 protein_coding processed_transcript 22.24464 18.21214 24.65569 2.84176 1.656055 0.4368131 4.408833 4.982464 3.387343 2.6790441 1.34467508 -0.5553451 0.20574167 0.2472333 0.13220000 -0.11503333 0.94637655 0.01076223   FALSE
ENST00000480666 ENSG00000183513 HEK293_OSMI2_2hA HEK293_TMG_2hB COA5 protein_coding retained_intron 22.24464 18.21214 24.65569 2.84176 1.656055 0.4368131 3.190482 1.552973 3.332656 0.3985138 0.32533647 1.0967020 0.14385833 0.0903000 0.13470000 0.04440000 0.42944348 0.01076223   FALSE
ENST00000483527 ENSG00000183513 HEK293_OSMI2_2hA HEK293_TMG_2hB COA5 protein_coding processed_transcript 22.24464 18.21214 24.65569 2.84176 1.656055 0.4368131 1.098876 1.388325 1.298872 0.7230473 0.29242323 -0.0953762 0.05154167 0.0896000 0.05163333 -0.03796667 1.00000000 0.01076223   FALSE
MSTRG.18920.3 ENSG00000183513 HEK293_OSMI2_2hA HEK293_TMG_2hB COA5 protein_coding   22.24464 18.21214 24.65569 2.84176 1.656055 0.4368131 2.372291 1.309042 3.275542 0.4828051 0.13389420 1.3166405 0.10450417 0.0680000 0.13350000 0.06550000 0.05293271 0.01076223   FALSE
MSTRG.18920.4 ENSG00000183513 HEK293_OSMI2_2hA HEK293_TMG_2hB COA5 protein_coding   22.24464 18.21214 24.65569 2.84176 1.656055 0.4368131 3.344971 3.780136 3.382470 0.9546763 0.43681425 -0.1599134 0.14902917 0.2194000 0.13976667 -0.07963333 0.65054871 0.01076223   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183513 E001 141.600823 0.0002572942 1.105109e-04 5.703065e-04 2 98599314 98600352 1039 - 2.201 2.095 -0.356
ENSG00000183513 E002 38.634321 0.0008459538 4.286607e-03 1.394496e-02 2 98600353 98600472 120 - 1.664 1.502 -0.553
ENSG00000183513 E003 43.409416 0.0115954896 5.475327e-02 1.175644e-01 2 98600473 98600518 46 - 1.583 1.708 0.425
ENSG00000183513 E004 234.560882 0.0002404077 1.399254e-08 1.679025e-07 2 98600519 98600793 275 - 2.321 2.436 0.386
ENSG00000183513 E005 1.549958 0.0115345992 2.456494e-01 3.808185e-01 2 98602382 98602645 264 - 0.320 0.523 1.100
ENSG00000183513 E006 159.347928 0.0022630865 1.117456e-01 2.081252e-01 2 98604108 98604191 84 - 2.185 2.239 0.180
ENSG00000183513 E007 38.846776 0.0323178089 1.302055e-01 2.344531e-01 2 98604192 98604790 599 - 1.662 1.502 -0.544
ENSG00000183513 E008 14.422505 0.0015064410 3.402345e-01 4.841941e-01 2 98605762 98605837 76 - 1.225 1.142 -0.295
ENSG00000183513 E009 18.003566 0.0010607492 1.268527e-04 6.449778e-04 2 98608078 98608196 119 - 1.397 1.076 -1.133
ENSG00000183513 E010 14.339141 0.0012845687 9.378374e-04 3.746662e-03 2 98608197 98608262 66 - 1.302 0.998 -1.087
ENSG00000183513 E011 11.832041 0.0015201177 2.119565e-01 3.408200e-01 2 98608263 98608306 44 - 1.164 1.046 -0.425
ENSG00000183513 E012 117.459549 0.0018650113 6.634499e-01 7.715264e-01 2 98608307 98608515 209 - 2.084 2.072 -0.043