ENSG00000183506

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000476537 ENSG00000183506 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 18.88917 16.57281 1.307192 1.048272 -0.1886343 1.8334379 0.2970871 1.8639031 0.1639582 0.5873823 2.609326 0.08818750 0.01696667 0.10896667 0.092000000 8.976932e-02 5.410863e-14   FALSE
ENST00000477296 ENSG00000183506 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 18.88917 16.57281 1.307192 1.048272 -0.1886343 3.2395950 2.9470729 2.5742540 0.5782173 0.2506816 -0.194422 0.15742500 0.15346667 0.15473333 0.001266667 1.000000e+00 5.410863e-14 TRUE FALSE
ENST00000479693 ENSG00000183506 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 18.88917 16.57281 1.307192 1.048272 -0.1886343 0.7434258 0.0000000 2.0370040 0.0000000 0.4286721 7.677370 0.03991250 0.00000000 0.12296667 0.122966667 5.410863e-14 5.410863e-14 FALSE TRUE
ENST00000480319 ENSG00000183506 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 18.88917 16.57281 1.307192 1.048272 -0.1886343 5.6898536 3.7924763 4.7926154 0.4110609 0.3448798 0.336881 0.28010833 0.20003333 0.28956667 0.089533333 2.906664e-02 5.410863e-14 FALSE TRUE
ENST00000494740 ENSG00000183506 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 18.88917 16.57281 1.307192 1.048272 -0.1886343 0.8288226 1.3445128 0.1900995 0.5127658 0.1900995 -2.758984 0.03902083 0.06836667 0.01173333 -0.056633333 1.192151e-01 5.410863e-14 TRUE TRUE
MSTRG.21712.10 ENSG00000183506 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KAP2 transcribed_unitary_pseudogene   20.25037 18.88917 16.57281 1.307192 1.048272 -0.1886343 0.3678329 1.4746120 0.0000000 0.8376345 0.0000000 -7.213942 0.02042083 0.08326667 0.00000000 -0.083266667 1.725565e-01 5.410863e-14 TRUE TRUE
MSTRG.21712.20 ENSG00000183506 HEK293_OSMI2_2hA HEK293_TMG_2hB PI4KAP2 transcribed_unitary_pseudogene   20.25037 18.88917 16.57281 1.307192 1.048272 -0.1886343 3.2873404 4.5414564 1.6566945 0.3801361 0.1462507 -1.449339 0.16183750 0.24416667 0.10006667 -0.144100000 5.200824e-04 5.410863e-14 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183506 E001 0.3299976 0.0282005238 0.343259980   22 21472540 21472541 2 - 0.000 0.184 9.322
ENSG00000183506 E002 0.3299976 0.0282005238 0.343259980   22 21472542 21472682 141 - 0.000 0.184 11.682
ENSG00000183506 E003 0.0000000       22 21473000 21473008 9 -      
ENSG00000183506 E004 0.0000000       22 21473009 21473010 2 -      
ENSG00000183506 E005 0.0000000       22 21473011 21473019 9 -      
ENSG00000183506 E006 0.0000000       22 21473020 21473020 1 -      
ENSG00000183506 E007 0.0000000       22 21473021 21473022 2 -      
ENSG00000183506 E008 0.0000000       22 21473023 21473034 12 -      
ENSG00000183506 E009 0.0000000       22 21473035 21473058 24 -      
ENSG00000183506 E010 0.0000000       22 21473059 21473075 17 -      
ENSG00000183506 E011 0.0000000       22 21473076 21473098 23 -      
ENSG00000183506 E012 0.0000000       22 21473099 21473100 2 -      
ENSG00000183506 E013 0.2214452 0.0361904102 0.717120748   22 21473101 21473135 35 - 0.000 0.102 10.682
ENSG00000183506 E014 12.1239874 0.0015234048 0.021664557 0.054980380 22 21473136 21473405 270 - 0.914 1.162 0.907
ENSG00000183506 E015 21.8490639 0.0108398668 0.035277703 0.082180599 22 21474597 21474680 84 - 1.199 1.400 0.701
ENSG00000183506 E016 17.9150831 0.0519853274 0.387539035 0.531680083 22 21474681 21474800 120 - 1.177 1.305 0.450
ENSG00000183506 E017 21.2042249 0.0687619661 0.091893856 0.178060912 22 21475211 21475300 90 - 1.129 1.397 0.943
ENSG00000183506 E018 7.2360539 0.0027246441 0.362706468 0.507124005 22 21475301 21475991 691 - 0.820 0.938 0.453
ENSG00000183506 E019 11.4001055 1.4366365676 0.481671245 0.619862324 22 21475992 21476001 10 - 0.705 1.191 1.838
ENSG00000183506 E020 37.7889762 0.0339926753 0.053864413 0.116013727 22 21476002 21476160 159 - 1.399 1.630 0.795
ENSG00000183506 E021 0.7332358 0.3853350655 0.731161200 0.822885380 22 21476161 21476223 63 - 0.255 0.191 -0.525
ENSG00000183506 E022 11.5968376 0.0213694660 0.983768212 0.993930652 22 21476224 21476643 420 - 1.072 1.084 0.042
ENSG00000183506 E023 33.5727804 0.0007165624 0.991354288 0.998660519 22 21476644 21476741 98 - 1.508 1.516 0.026
ENSG00000183506 E024 36.2653859 0.0078760563 0.871722628 0.921497409 22 21476742 21476764 23 - 1.529 1.553 0.081
ENSG00000183506 E025 38.8376912 0.0115545216 0.695754719 0.796270493 22 21476765 21477217 453 - 1.578 1.567 -0.038
ENSG00000183506 E026 4.2845781 0.0418200634 0.077578480 0.155576276 22 21477380 21477412 33 - 0.870 0.591 -1.143
ENSG00000183506 E027 19.2031935 0.0131268615 0.138881632 0.246563198 22 21477413 21477789 377 - 1.362 1.230 -0.465
ENSG00000183506 E028 62.8103868 0.0008586066 0.181547649 0.303172060 22 21477790 21477915 126 - 1.728 1.800 0.243
ENSG00000183506 E029 28.2710890 0.0009105365 0.470960813 0.610136653 22 21477997 21478101 105 - 1.398 1.456 0.199
ENSG00000183506 E030 1.3973850 0.2551464705 0.775638063 0.855459650 22 21478102 21478161 60 - 0.414 0.359 -0.311
ENSG00000183506 E031 1.7681702 0.3733309796 0.276692974 0.416166391 22 21478162 21478584 423 - 0.579 0.350 -1.173
ENSG00000183506 E032 58.9662799 0.0004781479 0.231988084 0.364816523 22 21478585 21478694 110 - 1.708 1.773 0.220
ENSG00000183506 E033 85.6336771 0.0009586145 0.730694581 0.822541022 22 21479759 21479829 71 - 1.919 1.914 -0.018
ENSG00000183506 E034 122.9873969 0.0016383952 0.149005014 0.260324549 22 21479930 21480002 73 - 2.097 2.055 -0.141
ENSG00000183506 E035 87.4351707 0.0004535945 0.411486599 0.555044583 22 21483020 21483090 71 - 1.936 1.913 -0.077
ENSG00000183506 E036 92.3618718 0.0007538616 0.139624876 0.247511124 22 21484005 21484134 130 - 1.976 1.929 -0.157
ENSG00000183506 E037 78.4889335 0.0003926528 0.228054477 0.360101323 22 21486800 21486927 128 - 1.900 1.860 -0.134
ENSG00000183506 E038 2.7594806 0.0072389473 0.309584735 0.451903927 22 21486928 21486975 48 - 0.415 0.593 0.866
ENSG00000183506 E039 51.1990904 0.0004972946 0.676570109 0.781511740 22 21487565 21487672 108 - 1.697 1.685 -0.042
ENSG00000183506 E040 52.5413816 0.0004833154 0.529734610 0.662464728 22 21487872 21488023 152 - 1.715 1.692 -0.076
ENSG00000183506 E041 18.0403712 0.0114538785 0.675927548 0.781040958 22 21488224 21488337 114 - 1.279 1.248 -0.108
ENSG00000183506 E042 12.5696917 0.0116325674 0.858968114 0.912997868 22 21488338 21488381 44 - 1.101 1.127 0.096
ENSG00000183506 E043 7.7769773 0.0021725750 0.975290397 0.988602430 22 21488382 21488410 29 - 0.914 0.925 0.041
ENSG00000183506 E044 10.1609619 0.0017834367 0.124814738 0.226859357 22 21488411 21488792 382 - 1.114 0.964 -0.549
ENSG00000183506 E045 26.0840958 0.0007973734 0.001629797 0.006056495 22 21488793 21490611 1819 - 1.524 1.319 -0.707
ENSG00000183506 E046 0.9170165 0.0149532404 0.976338561 0.989215774 22 21491976 21491993 18 - 0.255 0.254 -0.008
ENSG00000183506 E047 12.9163731 0.0015264400 0.248575685 0.384248163 22 21491994 21492094 101 - 1.042 1.161 0.432
ENSG00000183506 E048 0.0000000       22 21494880 21495023 144 -      
ENSG00000183506 E049 0.1817044 0.0398434224 0.716631603   22 21514130 21514133 4 - 0.000 0.102 10.664
ENSG00000183506 E050 0.0000000       22 21514134 21514255 122 -      
ENSG00000183506 E051 6.1111199 0.0028022041 0.781015940 0.859294884 22 21517325 21517533 209 - 0.845 0.817 -0.110