ENSG00000183474

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380729 ENSG00000183474 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2C protein_coding protein_coding 27.69423 9.887677 41.24905 1.489649 1.488581 2.059549 2.4334623 1.0683469 4.081571 0.1441367 0.6306738 1.923834 0.09763333 0.11623333 0.09890000 -0.01733333 9.009851e-01 1.681485e-14 FALSE TRUE
ENST00000510979 ENSG00000183474 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2C protein_coding protein_coding 27.69423 9.887677 41.24905 1.489649 1.488581 2.059549 1.3053486 0.0000000 2.912145 0.0000000 0.1554934 8.190884 0.03637083 0.00000000 0.07100000 0.07100000 1.681485e-14 1.681485e-14 FALSE TRUE
MSTRG.26326.12 ENSG00000183474 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2C protein_coding   27.69423 9.887677 41.24905 1.489649 1.488581 2.059549 8.9277595 3.4843775 7.513733 0.2988886 2.0376806 1.106413 0.31713333 0.37080000 0.18303333 -0.18776667 1.893083e-01 1.681485e-14 TRUE TRUE
MSTRG.26326.14 ENSG00000183474 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2C protein_coding   27.69423 9.887677 41.24905 1.489649 1.488581 2.059549 0.6934966 0.5252142 2.117207 0.5252142 2.1172069 1.990772 0.05002083 0.06203333 0.04916667 -0.01286667 8.908037e-01 1.681485e-14 TRUE TRUE
MSTRG.26326.3 ENSG00000183474 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2C protein_coding   27.69423 9.887677 41.24905 1.489649 1.488581 2.059549 4.3927994 1.3661876 6.298863 1.3661876 1.2586009 2.196703 0.11740417 0.10620000 0.15470000 0.04850000 2.849975e-01 1.681485e-14 TRUE TRUE
MSTRG.26326.8 ENSG00000183474 HEK293_OSMI2_2hA HEK293_TMG_2hB GTF2H2C protein_coding   27.69423 9.887677 41.24905 1.489649 1.488581 2.059549 5.0283411 1.5106675 10.011342 0.4534579 1.1268458 2.720299 0.18521250 0.14680000 0.24203333 0.09523333 1.106855e-01 1.681485e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183474 E001 0.4847352 0.2120545783 0.53542461 0.66725671 5 69560051 69560179 129 + 0.120 0.222 1.071
ENSG00000183474 E002 0.6319842 0.0196387222 0.76472413 0.84772361 5 69560180 69560190 11 + 0.169 0.222 0.487
ENSG00000183474 E003 1.6681372 0.1990158723 0.43621106 0.57831079 5 69560191 69560207 17 + 0.325 0.485 0.884
ENSG00000183474 E004 1.6681372 0.1990158723 0.43621106 0.57831079 5 69560208 69560208 1 + 0.325 0.485 0.884
ENSG00000183474 E005 1.9669016 0.2612053634 0.60323767 0.72406850 5 69560209 69560222 14 + 0.386 0.487 0.530
ENSG00000183474 E006 3.0072217 0.2654570104 0.70550482 0.80385428 5 69560223 69560224 2 + 0.530 0.571 0.188
ENSG00000183474 E007 18.3454975 0.0029550103 0.49536433 0.63218302 5 69560225 69560241 17 + 1.227 1.157 -0.250
ENSG00000183474 E008 21.0561568 0.0011733422 0.95951451 0.97857494 5 69560242 69560242 1 + 1.270 1.264 -0.022
ENSG00000183474 E009 15.6697834 0.0013164407 0.69825622 0.79826182 5 69560243 69560246 4 + 1.156 1.114 -0.151
ENSG00000183474 E010 19.9751534 0.0010804803 0.51510453 0.64980861 5 69560247 69560258 12 + 1.259 1.195 -0.224
ENSG00000183474 E011 28.7570052 0.0007525027 0.13383995 0.23948823 5 69560259 69560293 35 + 1.419 1.294 -0.433
ENSG00000183474 E012 31.8841398 0.0007901708 0.42641310 0.56924490 5 69560294 69560403 110 + 1.449 1.387 -0.216
ENSG00000183474 E013 0.5932625 0.1579505823 0.50757482 0.64304204 5 69560404 69560601 198 + 0.214 0.000 -12.168
ENSG00000183474 E014 0.0000000       5 69562652 69562672 21 +      
ENSG00000183474 E015 14.7307043 0.0012257030 0.36918492 0.51361852 5 69562673 69562770 98 + 1.142 1.042 -0.361
ENSG00000183474 E016 13.4147239 0.0012743629 0.71932538 0.81420514 5 69565100 69565121 22 + 1.077 1.114 0.133
ENSG00000183474 E017 11.5336347 0.0015086202 0.68570701 0.78836935 5 69565122 69565132 11 + 1.035 0.986 -0.182
ENSG00000183474 E018 14.7243867 0.0012223383 0.71765683 0.81296514 5 69565133 69565188 56 + 1.132 1.091 -0.145
ENSG00000183474 E019 0.1515154 0.0430190535 1.00000000   5 69565369 69566130 762 + 0.064 0.000 -10.632
ENSG00000183474 E020 11.5802950 0.0015936433 0.63716787 0.75109695 5 69566131 69566208 78 + 1.016 1.067 0.189
ENSG00000183474 E021 0.4513240 0.1714293181 0.56060592 0.68858387 5 69566209 69566486 278 + 0.120 0.220 1.054
ENSG00000183474 E022 9.4072011 0.0020552367 0.67553070 0.78078242 5 69566589 69566625 37 + 0.935 0.986 0.187
ENSG00000183474 E023 27.5368419 0.0053703288 0.58995615 0.71293518 5 69566967 69567053 87 + 1.375 1.419 0.154
ENSG00000183474 E024 0.0000000       5 69567054 69567215 162 +      
ENSG00000183474 E025 26.9002646 0.0009119780 0.72818393 0.82070711 5 69567727 69567777 51 + 1.372 1.398 0.091
ENSG00000183474 E026 64.7634831 0.0023986303 0.33131442 0.47491032 5 69568153 69568207 55 + 1.756 1.701 -0.187
ENSG00000183474 E027 0.1482932 0.0411597534 0.09877925   5 69568520 69570011 1492 + 0.000 0.222 12.550
ENSG00000183474 E028 100.8348082 0.0006513368 0.85040023 0.90719861 5 69572445 69572550 106 + 1.930 1.936 0.021
ENSG00000183474 E029 0.1515154 0.0430190535 1.00000000   5 69572551 69572844 294 + 0.064 0.000 -10.632
ENSG00000183474 E030 56.8853206 0.0014524328 0.59330977 0.71573456 5 69578712 69578802 91 + 1.692 1.660 -0.111
ENSG00000183474 E031 1.2147514 0.0106740521 0.62776032 0.74349200 5 69578803 69579020 218 + 0.324 0.222 -0.735
ENSG00000183474 E032 51.6167813 0.0006684121 0.71776624 0.81304096 5 69579021 69579108 88 + 1.650 1.627 -0.078
ENSG00000183474 E033 79.0567631 0.0003444037 0.18512376 0.30763204 5 69579757 69579864 108 + 1.814 1.871 0.194
ENSG00000183474 E034 45.0010276 0.0005618125 0.25747147 0.39458963 5 69582366 69582429 64 + 1.574 1.640 0.226
ENSG00000183474 E035 28.5719404 0.0007636903 0.02354596 0.05887562 5 69585594 69585697 104 + 1.357 1.519 0.558
ENSG00000183474 E036 7.7197039 0.0023810005 0.06932806 0.14224746 5 69586254 69586356 103 + 0.817 1.041 0.848
ENSG00000183474 E037 1.1018308 0.0246377053 0.55440295 0.68338848 5 69590328 69590367 40 + 0.254 0.368 0.751
ENSG00000183474 E038 0.8148214 0.0164888556 1.00000000 1.00000000 5 69592079 69592190 112 + 0.213 0.222 0.073
ENSG00000183474 E039 0.4418608 0.0265596925 0.67036036 0.77682547 5 69592191 69592330 140 + 0.169 0.000 -12.189
ENSG00000183474 E040 2.0704741 0.4107370635 0.13845783 0.24594556 5 69592331 69593472 1142 + 0.508 0.000 -13.433
ENSG00000183474 E041 0.5879639 0.0202765831 0.77016805 0.85159326 5 69593473 69593705 233 + 0.169 0.222 0.485
ENSG00000183474 E042 5.0607585 0.0032052137 0.09573317 0.18399101 5 69593706 69594243 538 + 0.772 0.477 -1.298
ENSG00000183474 E043 10.5224765 0.0016169180 0.08150530 0.16190558 5 69594244 69595221 978 + 1.035 0.802 -0.883
ENSG00000183474 E044 0.0000000       5 69600043 69600185 143 +      
ENSG00000183474 E045 0.1515154 0.0430190535 1.00000000   5 69603115 69603213 99 + 0.064 0.000 -10.632