ENSG00000183431

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373019 ENSG00000183431 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3A3 protein_coding protein_coding 113.9984 83.12923 150.1712 10.81304 5.953001 0.8531025 58.570330 60.6331785 63.921397 9.3743985 0.9943779 0.07617925 0.55839583 0.724600000 0.4265000 -0.29810000 2.077171e-15 1.496761e-52 FALSE TRUE
ENST00000489537 ENSG00000183431 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3A3 protein_coding processed_transcript 113.9984 83.12923 150.1712 10.81304 5.953001 0.8531025 9.799868 0.2677452 18.101155 0.1899167 3.5707440 6.02697275 0.06482500 0.003933333 0.1191333 0.11520000 5.813391e-04 1.496761e-52 FALSE TRUE
MSTRG.889.4 ENSG00000183431 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3A3 protein_coding   113.9984 83.12923 150.1712 10.81304 5.953001 0.8531025 8.947520 9.2325421 9.863825 1.1270044 3.0421594 0.09531939 0.07932917 0.111566667 0.0644000 -0.04716667 3.066223e-01 1.496761e-52 FALSE TRUE
MSTRG.889.5 ENSG00000183431 HEK293_OSMI2_2hA HEK293_TMG_2hB SF3A3 protein_coding   113.9984 83.12923 150.1712 10.81304 5.953001 0.8531025 29.245776 7.7493854 49.000046 0.9635488 1.4126280 2.65906322 0.23241250 0.096066667 0.3281000 0.23203333 6.224922e-08 1.496761e-52 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000183431 E001 249.7003086 0.0012565181 1.486150e-17 7.116951e-16 1 37956975 37957111 137 - 2.268 2.518 0.835
ENSG00000183431 E002 214.0418386 0.0017202699 6.264775e-14 1.832113e-12 1 37957112 37957119 8 - 2.203 2.451 0.825
ENSG00000183431 E003 1507.1540344 0.0007901325 2.118347e-45 1.015986e-42 1 37957120 37958062 943 - 3.058 3.285 0.753
ENSG00000183431 E004 1128.8703751 0.0002475388 6.689423e-20 4.192164e-18 1 37958063 37958263 201 - 2.996 3.118 0.405
ENSG00000183431 E005 862.0456953 0.0001339026 1.238357e-04 6.314050e-04 1 37960120 37960175 56 - 2.913 2.971 0.192
ENSG00000183431 E006 2.1443636 0.0072080393 2.146924e-01 3.440786e-01 1 37960176 37960693 518 - 0.386 0.598 1.049
ENSG00000183431 E007 893.7021962 0.0001004448 8.220739e-05 4.384186e-04 1 37968044 37968134 91 - 2.930 2.987 0.191
ENSG00000183431 E008 641.2870120 0.0005632478 3.616665e-03 1.205791e-02 1 37969354 37969386 33 - 2.784 2.844 0.199
ENSG00000183431 E009 814.0838590 0.0012322613 5.366693e-03 1.692645e-02 1 37969387 37969464 78 - 2.883 2.948 0.214
ENSG00000183431 E010 1162.9249638 0.0008154138 8.131539e-01 8.815312e-01 1 37969571 37969735 165 - 3.065 3.074 0.029
ENSG00000183431 E011 768.9263684 0.0001856982 1.916598e-03 6.966898e-03 1 37976884 37976953 70 - 2.909 2.873 -0.118
ENSG00000183431 E012 455.6974435 0.0001221436 8.329833e-04 3.376689e-03 1 37978720 37978722 3 - 2.688 2.639 -0.161
ENSG00000183431 E013 793.9779877 0.0002327825 1.425518e-04 7.145393e-04 1 37978723 37978827 105 - 2.927 2.880 -0.157
ENSG00000183431 E014 8.1855614 0.0030649150 2.801516e-01 4.199743e-01 1 37978828 37978987 160 - 1.019 0.905 -0.425
ENSG00000183431 E015 377.8562911 0.0001571913 1.285130e-04 6.524142e-04 1 37978988 37978989 2 - 2.613 2.549 -0.213
ENSG00000183431 E016 609.4084576 0.0003865207 9.001989e-03 2.628504e-02 1 37978990 37979052 63 - 2.808 2.770 -0.127
ENSG00000183431 E017 365.8739405 0.0014596610 9.493873e-02 1.827850e-01 1 37979053 37979055 3 - 2.587 2.546 -0.136
ENSG00000183431 E018 5.3667169 0.0030175650 1.285834e-01 2.321811e-01 1 37979056 37979199 144 - 0.896 0.705 -0.755
ENSG00000183431 E019 5.5506854 0.0030227568 1.317017e-01 2.365043e-01 1 37979391 37979464 74 - 0.896 0.705 -0.754
ENSG00000183431 E020 663.7572662 0.0008130571 1.362146e-01 2.427789e-01 1 37979465 37979533 69 - 2.838 2.813 -0.086
ENSG00000183431 E021 924.2164800 0.0003381394 3.053308e-02 7.301535e-02 1 37980586 37980724 139 - 2.982 2.957 -0.086
ENSG00000183431 E022 0.8147197 0.0147510598 4.831470e-01 6.212129e-01 1 37980725 37980789 65 - 0.196 0.324 0.956
ENSG00000183431 E023 764.1188245 0.0006023448 1.817178e-03 6.654534e-03 1 37981729 37981808 80 - 2.911 2.861 -0.166
ENSG00000183431 E024 455.4200913 0.0035031759 1.703225e-02 4.500541e-02 1 37981809 37981811 3 - 2.699 2.618 -0.272
ENSG00000183431 E025 0.3030308 0.3964133380 3.964378e-01   1 37984118 37984168 51 - 0.197 0.001 -8.742
ENSG00000183431 E026 838.4742238 0.0011392143 8.959957e-05 4.731268e-04 1 37984169 37984260 92 - 2.963 2.885 -0.260
ENSG00000183431 E027 675.2224641 0.0018536229 1.787725e-03 6.559989e-03 1 37984707 37984779 73 - 2.869 2.789 -0.266
ENSG00000183431 E028 748.0753430 0.0001716833 3.312851e-17 1.510856e-15 1 37987573 37987678 106 - 2.929 2.817 -0.373
ENSG00000183431 E029 626.1637132 0.0001310472 2.154337e-17 1.006989e-15 1 37987784 37987836 53 - 2.856 2.738 -0.393
ENSG00000183431 E030 614.9789367 0.0019885319 1.048401e-07 1.060929e-06 1 37989548 37989595 48 - 2.852 2.719 -0.441
ENSG00000183431 E031 3.2181981 0.0047732647 1.477541e-01 2.586352e-01 1 37989596 37989650 55 - 0.724 0.508 -0.951
ENSG00000183431 E032 657.0546953 0.0002150590 1.970999e-14 6.212461e-13 1 37989870 37990106 237 - 2.873 2.763 -0.363